Reactome | FH tetramer hydrates fumarate to L-malate

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FH tetramer hydrates fumarate to L-malate Show undefined attributes

catalystActivity	[CatalystActivity:70981] fumarate hydratase activity of FH tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643531] fumarate hydratase activity of FH tetramer [mitochondrial matrix] Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9854203] RHEA:12460 [DatabaseIdentifier:11881158] Rhea:12462
dbId	70982
displayName	FH tetramer hydrates fumarate to L-malate
eventOf	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent	[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens [Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate - Homo sapiens [Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR - Homo sapiens [Reaction:R-HSA-9012349] ME3 tetramer decarboxylates MAL to PYR - Homo sapiens
input	[SimpleEntity:R-ALL-113588] FUMA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:198390] Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency [LiteratureReference:9854194] Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase [LiteratureReference:9854210] The Pleiotropic Effects of Fumarate: From Mitochondrial Respiration to Epigenetic Rewiring and DNA Repair Mechanisms [LiteratureReference:9854207] Post-translational Modifications of Fumarase Regulate its Enzyme Activity and Function in Respiration and the DNA Damage Response
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	FH tetramer hydrates fumarate to L-malate fumarate + H2O => (S)-malate
orthologousEvent	[Reaction:R-GGA-373145] fumarate + H2O <=> malate - Gallus gallus [Reaction:R-MMU-70982] FH tetramer hydrates fumarate to L-malate - Mus musculus [Reaction:R-RNO-70982] FH tetramer hydrates fumarate to L-malate - Rattus norvegicus [Reaction:R-CFA-70982] FH tetramer hydrates fumarate to L-malate - Canis familiaris [Reaction:R-DDI-70982] FH tetramer hydrates fumarate to L-malate - Dictyostelium discoideum [Reaction:R-BTA-70982] FH tetramer hydrates fumarate to L-malate - Bos taurus [Reaction:R-SPO-70982] FH tetramer hydrates fumarate to L-malate - Schizosaccharomyces pombe [Reaction:R-DME-70982] FH tetramer hydrates fumarate to L-malate - Drosophila melanogaster [Reaction:R-SCE-70982] FH tetramer hydrates fumarate to L-malate - Saccharomyces cerevisiae [Reaction:R-CEL-70982] FH tetramer hydrates fumarate to L-malate - Caenorhabditis elegans [Reaction:R-GGA-70982] FH tetramer hydrates fumarate to L-malate - Gallus gallus [Reaction:R-SSC-70982] FH tetramer hydrates fumarate to L-malate - Sus scrofa [Reaction:R-DRE-70982] FH tetramer hydrates fumarate to L-malate - Danio rerio
output	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70994] SDH complex dehydrogenates succinate - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70982
summation	[Summation:71412] Mitochondrial fumarate hydratase (FH) tetramer catalyzes the...

Referrals

(hasEvent)	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL [Reaction:R-HSA-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR [Reaction:R-HSA-9012349] ME3 tetramer decarboxylates MAL to PYR

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