Reactome | SLC25A1 exchanges CIT and MAL

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SLC25A1 exchanges CIT and MAL Show undefined attributes

catalystActivity	[CatalystActivity:10564941] tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10564943
displayName	SLC25A1 exchanges CIT and MAL
eventOf	[Pathway:R-DRE-428643] Organic anion transport by SLC5/17/25 transporters - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-75848] ACLY tetramer transforms CIT to Ac-CoA - Danio rerio [Reaction:R-DRE-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Danio rerio [Reaction:R-DRE-372843] SLC25A10 mediates exchange of malate and phosphate - Danio rerio
inferredFrom	[Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL - Homo sapiens
input	[SimpleEntity:R-ALL-29654] CIT [mitochondrial matrix] [SimpleEntity:R-ALL-198498] MAL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A1 exchanges CIT and MAL SLC25A1 exports citrate from mitochondrion in exchange for malate Transport of Citrate from Mitochondrial Matrix to cytosol
output	[SimpleEntity:R-ALL-76190] CIT [cytosol] [SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane - Danio rerio [Reaction:R-DRE-70975] CS acetylates OA to citrate - Danio rerio [Reaction:R-DRE-372843] SLC25A10 mediates exchange of malate and phosphate - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-75849
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-428643] Organic anion transport by SLC5/17/25 transporters
(precedingEvent)	[Reaction:R-DRE-75848] ACLY tetramer transforms CIT to Ac-CoA [Reaction:R-DRE-372843] SLC25A10 mediates exchange of malate and phosphate [Reaction:R-DRE-198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
(inferredTo)	[Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL