KRAS G12C [plasma membrane]

Stable Identifier
R-HSA-6802331
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3845 KRAS
COSMIC (genes):KRAS KRAS
CTD Gene:3845 KRAS
dbSNP Gene:3845 KRAS
ENSEMBL:ENSG00000133703 KRAS
HGNC:6407 KRAS
KEGG Gene (Homo sapiens):3845 KRAS
Monarch:3845 KRAS
NCBI Gene:3845 KRAS
OMIM:190070 KRAS
UCSC:P01116 KRAS
Reference Transcript
Other Identifiers
0006110070
0007040129
11717962_x_at
11717963_a_at
11717964_a_at
11717965_s_at
16762399
1940_at
1D8D
1D8E
1KZO
1KZP
1N4P
1N4Q
1N4R
1N4S
204009_s_at
204010_s_at
214352_s_at
231640_at
2MSC
2MSD
2MSE
32159_at
3447860
3447862
3447864
3447865
3447866
3447867
3447868
3447869
3447870
3447871
3447872
3447873
3447874
3447879
3447880
3447884
3447886
3845
3958621
3GFT
49830
4DSN
4DSO
4EPR
4EPT
4EPV
4EPW
4EPX
4EPY
4L8G
4LDJ
4LPK
4LRW
4LUC
4LV6
4LYF
4LYH
4LYJ
4M1O
4M1S
4M1T
4M1W
4M1Y
4M21
4M22
4NMM
4OBE
4PZY
4PZZ
4Q01
4Q02
4Q03
4QL3
4TQ9
4TQA
4WA7
5F2E
5KYK
5MLA
5MLB
5O2S
5O2T
5OCG
5OCO
5OCT
5TAR
5TB5
5UFE
5UFQ
5UK9
5UQW
5US4
5USJ
5V6S
5V6V
5V71
5V9L
5V9O
5V9U
5VBM
5VP7
5VPI
5VPY
5VPZ
5VQ0
5VQ1
5VQ2
5VQ6
5VQ8
5W22
5WHA
5WHB
5WHD
5WHE
5WLB
5WPM
5XCO
5YXZ
5YY1
6ARK
6ASA
6ASE
6B0V
6B0Y
6BP1
6CC9
6CCH
6CCX
6EPL
6EPM
6EPN
6EPO
6EPP
6F76
6FA1
6FA2
6FA3
6FA4
6GQT
6GQW
6GQX
6GQY
6H46
6H47
6N2J
6N2K
7961865
A0A024RAV5
A_23_P306500
A_23_P306507
A_23_P45140
A_33_P3317815
AAA35683
AAA36149
AAA36554
AAA36557
AAB41942
AAB59444
AAB59445
AAH13572
AAM12631
AAP35817
ABY87538
AF493917
AGC09594
AK292510
BAF85199
BC013572
BT007153
CAA25828
CAA26593
CCDS8702
CCDS8703
CH471094
EAW96511
EAW96512
EAW96513
EAW96514
ENSG00000133703
ENSP00000256078
ENSP00000308495
ENST00000256078
ENST00000256078.8
ENST00000311936
ENST00000311936.7
EntrezGene:3845
EntrezGene:KRAS
EU332849
G3V4K2
G3V5T7
g4826811_3p_a_at
GE61031
GO:0000003
GO:0000165
GO:0000166
GO:0001889
GO:0001934
GO:0002223
GO:0002376
GO:0003674
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005925
GO:0006464
GO:0006950
GO:0007010
GO:0007165
GO:0007265
GO:0007267
GO:0007565
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008542
GO:0009058
GO:0010628
GO:0016020
GO:0019002
GO:0019003
GO:0019221
GO:0021897
GO:0030036
GO:0030154
GO:0030275
GO:0031234
GO:0031647
GO:0032228
GO:0034641
GO:0035022
GO:0035900
GO:0038002
GO:0042592
GO:0043167
GO:0043226
GO:0043406
GO:0043524
GO:0044877
GO:0045121
GO:0045596
GO:0048169
GO:0048856
GO:0048873
GO:0050877
GO:0051000
GO:0051092
GO:0051146
GO:0051384
GO:0051385
GO:0060441
GO:2000774
HGNC:6407
HPA049830
Hs.184050.0.S1_3p_a_at
Hs.184050.1.A1_3p_a_at
Hs.184050.4.A1_3p_at
ILMN_1652104
ILMN_1728071
IPR001806
IPR005225
IPR020849
IPR027417
JX512447
K01519
K01520
K03209
K03210
KRAS
KRAS-201
KRAS-202
L00045
L00046
L00047
L00048
L00049
L7RSL8
LRG_344
M25876
M30539
M34904
M54968
M54968_at
MIM:108010
MIM:109800
MIM:114480
MIM:137215
MIM:163200
MIM:190070
MIM:211980
MIM:260350
MIM:601626
MIM:609942
MIM:614470
MIM:615278
NM_001369786
NM_001369787
NM_004985
NM_033360
NP_001356715
NP_001356716
NP_004976
NP_203524
PF00071
PH_hs_0028364
PH_hs_0030345
PR00449
SM00173
SM00174
SM00175
SM00176
TC12001314.hg
UPI0000001252
UPI0000133132
X01669
X02825
Participant Of
hasMember
Other forms of this molecule
KRAS [plasma membrane]
KRAS A146T [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12A [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13C [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS F156L [plasma membrane]
KRAS L19F [plasma membrane]
KRAS G12D [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS K117N [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS V14I [plasma membrane]
KRAS G12V [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G13D [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G60R [plasma membrane]
KRAS D33E [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS G60V [plasma membrane]
KRAS G60D [plasma membrane]
KRAS E63K [plasma membrane]
KRAS A59T [plasma membrane]
Modified Residues
Name
glycine 12 replaced with L-cysteine
Coordinate
12
PsiMod
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
colorectal cancer 9256
lung cancer 1324
pancreatic cancer 1793 malignant neoplasm of tail of pancreas, pancreatic tumor, Ca body of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, malignant tumor of body of pancreas (disorder), Ca tail of pancreas (disorder), malignant neoplasm of head of pancreas, Ca tail of pancreas, malignant tumor of tail of pancreas (disorder), neoplasm of pancreas (disorder), Ca head of pancreas, Ca body of pancreas (disorder)
Cross References
RefSeq
COSMIC
OpenTargets
ZINC - Substances
GeneCards
HPA
Ensembl
ZINC target
PRO
Orphanet
PDB
4EPT, 4TQA, 4M1S, 6QUV, 4LYF, 1N4R, 6EPO, 5VP7, 6ASA, 5WLB, 5WHD, 5O2S, 6QUX, 5TB5, 4DSO, 6GOG, 5V6S, 6FA3, 1N4P, 4M1O, 4M1Y, 6FA4, 5XCO, 6EPP, 4Q03, 5VPZ, 6H46, 6GJ7, 4LRW, 5US4, 6B0V, 6CU6, 6CC9, 4NMM, 6MBT, 6EPM, 5OCT, 6GQY, 4LPK, 6P0Z, 1D8E, 5TAR, 1N4Q, 6CCX, 6GOF, 5UQW, 5WHB, 4M21, 6N2J, 5KYK, 5V9O, 6OB3, 5VPY, 1N4S, 6GJ6, 6GQT, 4EPY, 5OCO, 5UFQ, 5YY1, 5W22, 4EPV, 5V9U, 5VQ2, 6EPL, 4QL3, 6CCH, 4PZY, 5WHA, 6EPN, 4L8G, 6E6G, 5USJ, 6P8Y, 6GQX, 4OBE, 6MBQ, 5VPI, 6F76, 6FA1, 6GJ5, 4M22, 5V71, 4M1T, 4EPR, 6GOE, 5UFE, 4LYJ, 5WPM, 5OCG, 6MQG, 4LUC, 6MQN, 4Q01, 4M1W, 6ARK, 5UK9, 4DSN, 6OIM, 6FA2, 5VQ1, 5YXZ, 6BP1, 6E6F, 4EPX, 6MBU, 5V9L, 6OB2, 6GQW, 4LV6, 6P8Z, 4TQ9, 6ASE, 6GOD, 5VBM, 6P8W, 5V6V, 5VQ6, 4EPW, 5WHE, 6H47, 1KZP, 6GJ8, 6QUU, 5MLB, 5O2T, 6P8X, 5F2E, 6BOF, 1D8D, 6N2K, 5VQ8, 4Q02, 5MLA, 4LYH, 4PZZ, 1KZO, 5VQ0, 4WA7, 3GFT, 6GOM, 6B0Y, 6QUW, 6M9W, 4LDJ
Interactors (2)
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