G12C KRAS

Stable Identifier
R-HSA-6802331
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3845 KRAS
COSMIC (genes):KRAS KRAS
CTD Gene:3845 KRAS
dbSNP Gene:3845 KRAS
ENSEMBL:ENSG00000133703 KRAS
HGNC:6407 KRAS
KEGG Gene (Homo sapiens):hsa:3845 KRAS
Monarch:3845 KRAS
NCBI Gene:3845 KRAS
OMIM:190070 KRAS
UCSC:P01116 KRAS
Reference Transcript
Other Identifiers
0006110070
0007040129
11717962_x_at
11717963_a_at
11717964_a_at
11717965_s_at
16762399
1940_at
1D8D
1D8E
1KZO
1KZP
1N4P
1N4Q
1N4R
1N4S
204009_s_at
204010_s_at
214352_s_at
2MSC
2MSD
2MSE
32159_at
3447864
3447865
3447866
3447867
3447868
3447869
3447870
3447871
3447872
3447873
3447874
3447879
3447880
3447884
3447886
3845
3GFT
49830
4DSN
4DSO
4EPR
4EPT
4EPV
4EPW
4EPX
4EPY
4L8G
4LDJ
4LPK
4LRW
4LUC
4LV6
4LYF
4LYH
4LYJ
4M1O
4M1S
4M1T
4M1W
4M1Y
4M21
4M22
4NMM
4OBE
4PZY
4PZZ
4Q01
4Q02
4Q03
4QL3
4TQ9
4TQA
4WA7
5F2E
5KYK
5TAR
5TB5
5UQW
5US4
5USJ
5XCO
7961865
A0A024RAV5
A_23_P306500
A_23_P306507
A_23_P45140
A_33_P3317815
CCDS8702
CCDS8703
ENSG00000133703
ENSP00000256078
ENSP00000308495
ENST00000256078
ENST00000311936
EntrezGene:3845
g4826811_3p_a_at
GE61031
GO:0000165
GO:0000166
GO:0001889
GO:0001934
GO:0002223
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005925
GO:0007165
GO:0007173
GO:0007265
GO:0007411
GO:0007565
GO:0008284
GO:0008542
GO:0010628
GO:0016020
GO:0019002
GO:0019003
GO:0019221
GO:0021897
GO:0030036
GO:0030275
GO:0031234
GO:0031647
GO:0032228
GO:0032403
GO:0035022
GO:0035900
GO:0038002
GO:0038095
GO:0038128
GO:0043406
GO:0043524
GO:0045121
GO:0045596
GO:0048169
GO:0048873
GO:0050900
GO:0051000
GO:0051092
GO:0051146
GO:0051384
GO:0051385
GO:0060441
GO:2000774
HGNC:6407
HPA049830
Hs.184050.0.S1_3p_a_at
Hs.184050.1.A1_3p_a_at
ILMN_1652104
ILMN_1728071
KRAS
KRAS-201
KRAS-202
L7RSL8
M54968_at
MIM:109800
MIM:114480
MIM:137215
MIM:163200
MIM:190070
MIM:211980
MIM:260350
MIM:601626
MIM:609942
MIM:615278
NM_004985
NM_033360
NP_004976
NP_203524
PF00071
PH_hs_0028364
PH_hs_0030345
PR00449
SM00173
SM00174
SM00175
SM00176
TC12001314.hg
uc001rgp.3
uc001rgq.2
UPI0000001252
UPI0000133132
XM_006719069
XM_011520653
XM_017019293
XP_006719132
XP_011518955
XP_016874782
Participant Of
hasMember
Other forms of this molecule
G12D KRAS [plasma membrane]
V14I KRAS [plasma membrane]
G12V KRAS [plasma membrane]
D153V KRAS [plasma membrane]
G13D KRAS [plasma membrane]
T58I KRAS [plasma membrane]
Q61H KRAS [plasma membrane]
KRAS [plasma membrane]
Modified Residues
Name
glycine 12 replaced with L-cysteine
Coordinate
12
PsiMod HEY
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
colorectal cancer 9256
lung cancer 1324
pancreatic cancer 1793 malignant neoplasm of tail of pancreas, pancreatic tumor, Ca body of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, malignant tumor of body of pancreas (disorder), Ca tail of pancreas (disorder), malignant neoplasm of head of pancreas, Ca tail of pancreas, malignant tumor of tail of pancreas (disorder), neoplasm of pancreas (disorder), Ca head of pancreas, Ca body of pancreas (disorder)
Cross References
RefSeq
Brenda
GeneCards
ZINC - Substances
DOCK Blaster
ZINC target
PRO
COSMIC (mutations)
Orphanet
HMDB Protein
PDB
Interactors (1)