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KRAS A59T [plasma membrane]
Stable Identifier
R-HSA-9653079
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
RAS GTPase cycle mutants (Homo sapiens)
Signaling by RAS GAP mutants (Homo sapiens)
RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
RAS GAP mutants:GTP [plasma membrane] (Homo sapiens)
RAS GAP mutants [plasma membrane] (Homo sapiens)
KRAS A59T [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Reference Genes
ENSEMBL:ENSG00000133703 KRAS
Participates
as a candidate of
RAS GAP mutants [plasma membrane] (Homo sapiens)
Other forms of this molecule
S-Farn-Me-PalmS KRAS [plasma membrane]
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
KRAS A146T [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12A [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13C [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS F156L [plasma membrane]
KRAS G12C [plasma membrane]
proKRAS [cytosol]
S-Farn-proKRAS [endoplasmic reticulum membrane]
S-Farn-KRAS [endoplasmic reticulum membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
KRAS [plasma membrane]
KRAS E63K [plasma membrane]
KRAS G60D [plasma membrane]
KRAS G60V [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS D33E [plasma membrane]
KRAS G60R [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G13D [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G12V [plasma membrane]
KRAS V14I [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS K117N [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS G12D [plasma membrane]
KRAS L19F [plasma membrane]
Modified Residues
Name
L-alanine 59 replaced with L-threonine
Coordinate
59
PsiMod
L-alanine removal [MOD:01631]
A protein modification that effectively removes or replaces an L-alanine.
L-threonine residue [MOD:00026]
A protein modification that effectively converts a source amino acid residue to L-threonine.
Disease
Name
Identifier
Synonyms
lung cancer
DOID:1324
colorectal cancer
DOID:9256
hematologic cancer
DOID:2531
hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
Cross References
COSMIC
COSM1716362
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.695
6
UniProt:Q99755 PIP5K1A
1
PIP5K1A [cytosol]
(R-HSA-1806260)
0.661
9
UniProt:P15056 BRAF
20
p-S,T-BRAF [cytosol]
(R-HSA-169856)
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
0.615
4
UniProt:Q96II5 Q96II5
0.556
3
UniProt:P50749 RASF2
0.544
2
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
0.519
2
UniProt:O75915 ARL6IP5
1
ARL6IP5 [cytosol]
(R-HSA-2980942)
0.519
2
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.483
2
UniProt:P28288 ABCD3
2
ABCD3 [cytosol]
(R-HSA-1456459)
ABCD3 [peroxisomal membrane]
(R-HSA-1456468)
0.483
2
UniProt:P01111 NRAS
20
S-Farn-Me PalmS NRAS [plasma membrane]
(R-HSA-9647910)
proNRAS [cytosol]
(R-HSA-9647758)
S-Farn-proNRAS [endoplasmic reticulum membrane]
(R-HSA-9647928)
S-Farn NRAS [endoplasmic reticulum membrane]
(R-HSA-9647782)
S-Farn-Me NRAS [endoplasmic reticulum membrane]
(R-HSA-9647891)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
NRAS [plasma membrane]
(R-HSA-62725)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
0.483
2
UniProt:Q7KZI7 MARK2
0.483
2
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.483
2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE
0.462
2
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