KRAS G12S [plasma membrane]

Stable Identifier
R-HSA-9649629
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
18024870 Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer

Zhu, CQ, Aviel-Ronen, S, Shepherd, FA, Ding, K, Johnson, DH, Livingston, R, Winton, T, Sakurada, A, Rigas, J, Seymour, L, Lau, D, Tsao, MS, Liu, N, Whitehead, M

J. Clin. Oncol. 2007
29360550 Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

Oosawa, A, Ariizumi, SI, Fassan, M, Fujita, M, Miyano, S, Yamaue, H, Maejima, K, Lawlor, RT, Hatanaka, Y, Polak, P, Furuta, M, Nakagawa, H, Chayama, K, Hayami, S, Kim, J, Scarpa, A, Yamamoto, M, Ueno, M, Karlic, R, Conci, S, Sasaki-Oku, A, Kawakami, Y, Yamamoto, Y, Mitsuhashi, T, Simbolo, M, Hirano, S, Nakano, K, Yamada, T, Fujimoto, A, Michiaki, K, Wardell, CP, Ruzzenente, A, Aikata, H, Nakamura, T, Tanaka, H, Gotoh, K, Nakanishi, Y, Getz, G

J. Hepatol. 2018
16900509 Distinctive clinicopathological features of Ki-ras mutated colorectal cancers

Yang, SH, Wang, HS, Lin, TC, Chang, SC, Jiang, JK, Chen, WC, Lin, JK, Li, AF

J Surg Oncol 2006
External Reference Information
External Reference
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Participates
Other forms of this molecule
Modified Residues
Name
glycine 12 replaced with L-serine
Coordinate
12
PsiMod
A protein modification that effectively removes or replaces an glycine.
A protein modification that effectively converts a source amino acid residue to L-serine.
Disease
Name Identifier Synonyms
lung cancer DOID:1324
biliary tract cancer DOID:4607 malignant tumour of biliary tract
colorectal cancer DOID:9256
Cross References
COSMIC
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:P15056 BRAF  20 0.615 4
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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