KRAS F156L [plasma membrane]

Stable Identifier
R-HSA-9651372
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
20949621 Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

Cirstea, IC, Ahmadian, MR, Merbitz-Zahradnik, T, Zenker, M, Dvorsky, R, Gremer, L, Wittinghofer, A, Kratz, CP

Hum. Mutat. 2011
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Reference Genes
ENSEMBL:ENSG00000133703 KRAS
Participates
as a member of
Other forms of this molecule
S-Farn-Me-PalmS KRAS [plasma membrane]
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
KRAS A146T [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12A [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13C [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS G12C [plasma membrane]
proKRAS [cytosol]
S-Farn-proKRAS [endoplasmic reticulum membrane]
S-Farn-KRAS [endoplasmic reticulum membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
KRAS [plasma membrane]
KRAS A59T [plasma membrane]
KRAS E63K [plasma membrane]
KRAS G60D [plasma membrane]
KRAS G60V [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS D33E [plasma membrane]
KRAS G60R [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G13D [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G12V [plasma membrane]
KRAS V14I [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS K117N [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS G12D [plasma membrane]
KRAS L19F [plasma membrane]
Modified Residues
Name
L-phenylalanine 156 replaced with L-leucine
Coordinate
156
PsiMod
L-leucine residue [MOD:00020]
A protein modification that effectively converts a source amino acid residue to an L-leucine.
L-phenylalanine removal [MOD:01644]
A protein modification that effectively removes or replaces an L-phenylalanine.
Disease
Name Identifier Synonyms
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
cardiofaciocutaneous syndrome DOID:0060233 CFC syndrome, cardio-facial-cutaneous syndrome
skin melanoma DOID:8923 malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
Cross References
COSMIC
ClinGen
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:P15056 BRAF  20 0.615 4
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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