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SYF2 [nucleoplasm]
Stable Identifier
R-HSA-8867884
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pre-mRNA-splicing factor SYF2, SYF2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
SYF2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95926 SYF2
Gene Names
SYF2, CBPIN, GCIPIP
Chain
initiator methionine:, chain:2-243
Reference Genes
BioGPS Gene:25949 SYF2
COSMIC (genes):SYF2 SYF2
CTD Gene:25949 SYF2
dbSNP Gene:25949 SYF2
ENSEMBL:ENSG00000117614 SYF2
HGNC:19824 SYF2
KEGG:hsa:25949 SYF2
Monarch:25949 SYF2
NCBI Gene:25949 SYF2
OMIM:607090 SYF2
UCSC:O95926 SYF2
Reference Transcript
RefSeq:NM_015484.4 SYF2
RefSeq:NM_207170.3 SYF2
Other Identifiers
11739101_a_at
11739102_a_at
1559979_PM_at
1559979_at
16683644
202553_PM_s_at
202553_s_at
2402085
2402086
2402087
2402088
2402089
2402090
2402092
2402093
2402094
2402095
2402096
2402097
2402098
25949
32792_at
53454_r_at
7913814
A_23_P45756
A_24_P920102
A_33_P3264272
GE61206
GO:0000398
GO:0000974
GO:0001701
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0006397
GO:0007095
GO:0007369
GO:0008284
GO:0008380
GO:0016071
GO:0016607
GO:0043226
GO:0048568
GO:0048856
GO:0071007
GO:0071013
GO:0071014
HMNXSV003010671
Hs2.290519.1.S1_3p_at
ILMN_1660186
ILMN_2287296
ILMN_2394498
PH_hs_0001741
PH_hs_0037727
TC01002373.hg
g7661635_3p_a_at
Participates
as an output of
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
as an input of
Formation of the Spliceosomal B* complex (Homo sapiens)
as a component of
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
Inferred To
Syf2 [nucleoplasm]
(Drosophila melanogaster)
Syf2 [nucleoplasm]
(Mus musculus)
Syf2 [nucleoplasm]
(Rattus norvegicus)
syf2 [nucleoplasm]
(Danio rerio)
syf2 [nucleoplasm]
(Dictyostelium discoideum)
syf2 [nucleoplasm]
(Schizosaccharomyces pombe)
syf2 [nucleoplasm]
(Xenopus tropicalis)
LOC478184 [nucleoplasm]
(Canis familiaris)
SYF2 [nucleoplasm]
(Bos taurus)
SYF2 [nucleoplasm]
(Gallus gallus)
SYF2 [nucleoplasm]
(Plasmodium falciparum)
SYF2 [nucleoplasm]
(Sus scrofa)
syf-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_056299.1
,
NP_997053.1
OpenTargets
ENSG00000117614
ENSEMBL
ENST00000354361
,
ENST00000236273
,
ENSP00000236273
,
ENSP00000346330
HPA
ENSG00000117614-SYF2
PRO
O95926
Pharos - Targets
O95926
PDB
6ID1
,
5YZG
,
6ICZ
,
8C6J
,
5MQF
,
7A5P
,
6QDV
,
7W59
,
5XJC
,
6ID0
,
7W5B
,
7W5A
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60306 AQR
1
AQR [nucleoplasm]
(R-HSA-6781960)
0.648
4
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:Q9H6L4 ARMC7
0.556
3
UniProt:O95273 CCDB1
0.556
3
UniProt:P40692 MLH1
3
MLH1 [nucleoplasm]
(R-HSA-912495)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
0.556
3
UniProt:Q8WUD4 CCDC12
1
CCDC12 [nucleoplasm]
(R-HSA-9769561)
0.527
3
UniProt:P16383 GCFC2
1
GCFC2 [nucleoplasm]
(R-HSA-8869311)
0.527
2
UniProt:Q9H5Z1 DHX35
1
DHX35 [nucleoplasm]
(R-HSA-9770427)
0.527
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
3
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.527
3
UniProt:Q9UMS4 PRPF19
1
PRPF19 [nucleoplasm]
(R-HSA-5420907)
0.527
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.527
2
UniProt:P63162 SNRPN
1
Me2-R108,R112-SNRPN [nucleoplasm]
(R-HSA-8865931)
0.527
3
UniProt:Q9BRX9 WDR83
1
WDR83 [endosome membrane]
(R-HSA-5672942)
0.527
4
UniProt:P09661 SNRPA1
1
SNRPA1 [nucleoplasm]
(R-HSA-71958)
0.527
2
UniProt:O60508 CDC40
1
CDC40 [nucleoplasm]
(R-HSA-72062)
0.527
3
UniProt:Q9HCS7 XAB2
1
XAB2 [nucleoplasm]
(R-HSA-67411)
0.527
3
UniProt:O75934 BCAS2
1
BCAS2 [nucleoplasm]
(R-HSA-5420902)
0.527
3
UniProt:Q9BRR8 GPATCH1
1
GPATCH1 [nucleoplasm]
(R-HSA-9770419)
0.527
3
UniProt:Q9H0C5 BTBD1
1
BTBD1 [cytosol]
(R-HSA-8851650)
0.527
2
UniProt:Q9BW85 YJU2
1
YJU2 [nucleoplasm]
(R-HSA-9770430)
0.527
2
UniProt:Q86VM9 ZCH18
0.527
2
UniProt:P41223 BUD31
1
BUD31 [nucleoplasm]
(R-HSA-8867891)
0.527
2
UniProt:Q96DF8 ESS2
0.527
2
UniProt:P62304 SNRPE
2
SNRPE [cytosol]
(R-HSA-191782)
SNRPE [nucleoplasm]
(R-HSA-71905)
0.527
4
UniProt:Q2TBE0 CWF19L2
1
CWF19L2 [nucleoplasm]
(R-HSA-9770846)
0.527
2
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.527
3
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