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CPLX1 [cytosol]
Stable Identifier
R-HSA-210385
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
complexin 1
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Acetylcholine Neurotransmitter Release Cycle (Homo sapiens)
Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Release of acetylcholine at the synapse (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Dopamine synaptic vesicle docking and priming (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Release of GABA at the synapse (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Release of L-Glutamate at the synapse (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Release of noradrenaline at the synapse (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
CPLX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14810 CPLX1
Gene Names
CPLX1
Chain
chain:1-134
Reference Genes
BioGPS Gene:10815 CPLX1
COSMIC (genes):CPLX1 CPLX1
CTD Gene:10815 CPLX1
dbSNP Gene:10815 CPLX1
ENSEMBL:ENSG00000168993 CPLX1
ENSEMBL:ENSG00000168993.15 CPLX1
HGNC:2309 CPLX1
KEGG Gene (Homo sapiens):10815 CPLX1
Monarch:10815 CPLX1
NCBI Gene:10815 CPLX1
OMIM:605032 CPLX1
UCSC:O14810 CPLX1
Reference Transcript
RefSeq:NM_006651.3 CPLX1
Other Identifiers
10815
11758141_s_at
16973365
223500_PM_at
223500_at
2756632
2756633
2756634
2756635
2756636
2756637
2756638
2756639
2756640
2756649
2756650
2756656
2756657
2756658
56134_at
8098782
A_23_P212812
A_24_P51909
GE62156
GO:0000149
GO:0005215
GO:0005326
GO:0005515
GO:0005737
GO:0005829
GO:0006836
GO:0006887
GO:0007268
GO:0016079
GO:0016192
GO:0017157
GO:0019905
GO:0023052
GO:0030073
GO:0031201
GO:0031630
GO:0042995
GO:0043195
GO:0043204
GO:0044305
GO:0045202
GO:0046928
GO:0061024
GO:0070554
GO:0098685
GO:0098793
GO:0098794
GO:0098978
GO:0099145
GO:0110165
HMNXSV003000232
ILMN_1801703
PH_hs_0013187
TC04000956.hg
g12803306_3p_at
Participates
as an input of
Dopamine synaptic vesicle docking and priming (Homo sapiens)
Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
as an output of
Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
Release of acetylcholine at the synapse (Homo sapiens)
Release of noradrenaline at the synapse (Homo sapiens)
Release of L-Glutamate at the synapse (Homo sapiens)
Release of GABA at the synapse (Homo sapiens)
Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
as a component of
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Inferred To
cplx1 [cytosol]
(Xenopus tropicalis)
cpx-1 [cytosol]
(Caenorhabditis elegans)
Cplx1 [cytosol]
(Mus musculus)
Cplx1 [cytosol]
(Rattus norvegicus)
CPLX1 [cytosol]
(Bos taurus)
CPLX1 [cytosol]
(Canis familiaris)
CPLX1 [cytosol]
(Gallus gallus)
CPLX1 [cytosol]
(Sus scrofa)
cpx [cytosol]
(Drosophila melanogaster)
cplx2a [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_006642.1
OpenTargets
ENSG00000168993
HPA
ENSG00000168993-CPLX1
GeneCards
O14810
Ensembl
ENST00000304062
,
ENSG00000168993
,
ENSP00000305613
PRO
O14810
Pharos - Targets
O14810
Orphanet
25557
PDB
3RK3
,
3RL0
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60880-2 SNAP25
0.733
6
UniProt:P63027 VAMP2
20
VAMP2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869129)
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-379363)
VAMP2 [plasma membrane]
(R-HSA-210516)
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917738)
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-210365)
VAMP2 [synaptic vesicle membrane]
(R-HSA-181517)
VAMP2(59-116) [synaptic vesicle membrane]
(R-HSA-5250891)
VAMP2(2-58) [cytosol]
(R-HSA-194815)
VAMP2(2-76) [cytosol]
(R-HSA-194802)
VAMP2(77-116) [synaptic vesicle membrane]
(R-HSA-5228355)
VAMP2(60-116) [synaptic vesicle membrane]
(R-HSA-5250615)
VAMP2(2-59) [cytosol]
(R-HSA-194797)
VAMP2(82-116) [synaptic vesicle membrane]
(R-HSA-5250961)
VAMP2(2-81) [cytosol]
(R-HSA-5250970)
VAMP2 [secretory granule membrane]
(R-HSA-376363)
VAMP2 [cytosol]
(R-HSA-9609882)
VAMP2 [endoplasmic reticulum membrane]
(R-HSA-9609886)
VAMP2 [cytoplasmic vesicle membrane]
(R-HSA-1449630)
VAMP2 [lysosomal membrane]
(R-HSA-432703)
VAMP2 [Golgi membrane]
(R-HSA-375425)
0.656
3
UniProt:P32851 Stx1a
2
Stx1a [cytosol]
(R-RNO-9609866)
Stx1a [plasma membrane]
(R-RNO-6794247)
0.656
3
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