Reactome | STX1B(?-288) [plasma membrane]

STX1B(?-288) [plasma membrane]

Stable Identifier

R-HSA-5246519

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Syntaxin 1B carboxyterminal fragment

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Uptake and actions of bacterial toxins (Homo sapiens)
      - Neurotoxicity of clostridium toxins (Homo sapiens)
        
        Toxicity of botulinum toxin type C (botC) (Homo sapiens)
        
        botC LC cleaves target cell STX1 (Homo sapiens)
        
        STX1(?-288) [plasma membrane] (Homo sapiens)
        
        STX1B(?-288) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61266 STX1B

Gene Names

STX1B, STX1B1, STX1B2

Chain

chain:1-288

Reference Genes

BioGPS Gene:112755 STX1B

COSMIC (genes):STX1B STX1B

CTD Gene:112755 STX1B

dbSNP Gene:112755 STX1B

ENSEMBL:ENSG00000099365 STX1B

ENSEMBL_homo_sapiens_GENE:ENSG00000099365.11 STX1B

HGNC:18539 STX1B

KEGG Gene (Homo sapiens):112755 STX1B

Monarch:112755 STX1B

NCBI Gene:112755 STX1B

OMIM:601485 STX1B

UCSC:P61266 STX1B

Reference Transcript

RefSeq:NM_052874.4 STX1B

Other Identifiers

112755

11729945_at

11729946_at

16825911

230691_PM_at

230691_at

3688107

3688109

3688111

3688113

3688114

3688115

3688116

3688117

3688119

3688121

3688122

3688123

3688124

3688125

3688127

3688129

3688130

3688132

3688133

3688135

3688139

3688140

56284_at

8000963

A_23_P152462

A_33_P3326382

GE56921

GO:0000149

GO:0001956

GO:0005102

GO:0005484

GO:0005515

GO:0005634

GO:0005652

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0006836

GO:0006886

GO:0006904

GO:0006906

GO:0010468

GO:0010807

GO:0010977

GO:0012505

GO:0016020

GO:0016079

GO:0016081

GO:0016192

GO:0019901

GO:0023052

GO:0030154

GO:0030424

GO:0031201

GO:0031594

GO:0031629

GO:0043226

GO:0048278

GO:0048791

GO:0048856

GO:0050877

GO:0060025

GO:0060090

GO:0061024

GO:0061669

GO:0065003

GO:0098793

GO:0098967

GO:1903422

GO:1904050

GO:1905302

GO:2000463

HMNXSV003009807

HMNXSV003013143

HMNXSV003027091

Hs.21782.0.A1_3p_at

ILMN_1660721

PH_hs_0024290

PH_hs_0038944

TC16001047.hg

Participates

as a member of

STX1(?-288) [plasma membrane] (Homo sapiens)

Other forms of this molecule

STX1B(1-?) [cytosol]

STX1B [plasma membrane]

Disease

Name	Identifier	Synonyms
botulism	DOID:11976	Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning

Cross References

RefSeq

NP_443106.1

OpenTargets

ENSG00000099365

HPA

ENSG00000099365-STX1B

GeneCards

P61266

Ensembl

ENST00000565419, ENSG00000099365, ENSP00000215095, ENSP00000455899, ENST00000215095

PRO

P61266

Pharos - Targets

P61266

Orphanet

23093

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.659	4
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.556	3
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.556	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3