Reactome | STX3 [plasma membrane]

STX3 [plasma membrane]

Stable Identifier

R-HSA-449131

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Syntaxin-3, STX3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13277 STX3

Gene Names

STX3, STX3A

Chain

chain:1-289

Reference Genes

BioGPS Gene:6809 STX3

COSMIC (genes):STX3 STX3

CTD Gene:6809 STX3

dbSNP Gene:6809 STX3

ENSEMBL:ENSG00000166900 STX3

ENSEMBL_homo_sapiens_GENE:ENSG00000166900.17 STX3

HGNC:11438 STX3

KEGG Gene (Homo sapiens):6809 STX3

Monarch:6809 STX3

NCBI Gene:6809 STX3

OMIM:600876 STX3

UCSC:Q13277 STX3

Reference Transcript

Other Identifiers

11719533_a_at

11719534_a_at

11747878_a_at

11750017_a_at

16725112

209238_PM_at

209238_at

216985_PM_s_at

216985_s_at

235483_PM_at

235483_at

3332144

3332145

3332150

3332160

3332162

3332164

3332165

3332166

3332167

3332169

3332170

3332174

3332175

3332183

3332184

3332185

3332186

3332187

3332188

3332190

38381_at

51631_at

6809

71621_r_at

7940191

A_14_P101995

A_14_P119760

A_23_P139143

GE582017

GE59084

GO:0000149

GO:0001750

GO:0001917

GO:0005484

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005764

GO:0005773

GO:0005886

GO:0005911

GO:0005929

GO:0006836

GO:0006886

GO:0006887

GO:0007155

GO:0008021

GO:0008284

GO:0008289

GO:0010468

GO:0012505

GO:0016020

GO:0016192

GO:0016324

GO:0023052

GO:0030027

GO:0030141

GO:0030154

GO:0030425

GO:0030426

GO:0031175

GO:0031201

GO:0031410

GO:0031629

GO:0042470

GO:0042581

GO:0042582

GO:0042589

GO:0043005

GO:0043226

GO:0045785

GO:0048278

GO:0048787

GO:0048856

GO:0050544

GO:0050804

GO:0050921

GO:0060090

GO:0060291

GO:0061024

GO:0061025

GO:0070062

GO:0072659

GO:0090174

GO:0098685

GO:0098794

GO:0098967

GO:0098978

GO:0099003

GO:1903078

GO:2000010

HMNXSV003054941

Hs.180711.0.S1_3p_at

Hs.82240.0.S3_3p_at

Hs.82240.1.S1_3p_a_at

ILMN_1659544

PH_hs_0004706

PH_hs_0010694

TC11000499.hg

TC11002689.hg

U32315_at

Participates

as a component of

TXLNA:STX3 [plasma membrane] (Homo sapiens)

as an input of

TXLNA (IL14) binds syntaxin3 (Homo sapiens)

Inferred To

Syx1A [plasma membrane] (Drosophila melanogaster)

Stx3 [plasma membrane] (Mus musculus)

Stx3 [plasma membrane] (Rattus norvegicus)

syx-2 [plasma membrane] (Caenorhabditis elegans)

unc-64 [plasma membrane] (Caenorhabditis elegans)

Homologues of STX3 [plasma membrane] (Caenorhabditis elegans)

Homologues of STX3 [plasma membrane] (Dictyostelium discoideum)

syn1B [plasma membrane] (Dictyostelium discoideum)

STX3 [plasma membrane] (Bos taurus)

STX3 [plasma membrane] (Canis familiaris)

STX3 [plasma membrane] (Gallus gallus)

STX3 [plasma membrane] (Sus scrofa)

syn1A [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

XP_005274257.1, NP_001171511.1, NP_004168.1, XP_005274252.1

OpenTargets

ENSG00000166900

GeneCards

Q13277

HPA

ENSG00000166900-STX3

Ensembl

ENSP00000433248, ENST00000529177, ENSP00000338562, ENSG00000166900, ENST00000337979

PRO

Q13277

Pharos - Targets

Q13277

Orphanet

22962

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.83	8
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.83	8
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.666	5
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.666	4
UniProt:O95405 ZFYVE9			0.571	3
UniProt:Q9NQG1 MANBL			0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q96MV8 ZDH15			0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:O00559 EBAG9	1	EBAG9 [Golgi membrane] (R-HSA-9018507)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:P49447 CY561			0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q9NQQ7-3 Q9NQQ73			0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q5SR56 MF14B			0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q15800 MSMO1	1	MSMO1 [endoplasmic reticulum membrane] (R-HSA-194648)	0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:O75208 COQ9	1	COQ9 [mitochondrial inner membrane] (R-HSA-8932994)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q6ZT21 TMPPE			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:Q96TC7 RMD3			0.556	3
UniProt:O00161 SNAP23	5	SNAP23 [tertiary granule membrane] (R-HSA-6806141) SNAP23 [plasma membrane] (R-HSA-376345) SNAP23 [specific granule membrane] (R-HSA-6806157) p-S95-SNAP23 [phagocytic vesicle membrane] (R-HSA-8863923) SNAP23 [phagocytic vesicle membrane] (R-HSA-8863966)	0.547	2
UniProt:O95183 VAMP5			0.527	2
UniProt:Q15833 STXBP2	2	STXBP2 [extracellular region] (R-HSA-8862990) STXBP2 [cytosol] (R-HSA-5617151)	0.527	4
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.527	4
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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