Reactome | CERS4 [endoplasmic reticulum membrane]

CERS4 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428138

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

LASS4, LAG1 homolog, ceramide synthase 4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9HA82 CERS4

Gene Names

CERS4, LASS4

Chain

chain:1-394

Reference Genes

BioGPS Gene:79603 CERS4

COSMIC (genes):CERS4 CERS4

CTD Gene:79603 CERS4

dbSNP Gene:79603 CERS4

ENSEMBL:ENSG00000090661 CERS4

ENSEMBL_homo_sapiens_GENE:ENSG00000090661.12 CERS4

HGNC:23747 CERS4

KEGG Gene (Homo sapiens):79603 CERS4

Monarch:79603 CERS4

NCBI Gene:79603 CERS4

OMIM:615334 CERS4

UCSC:Q9HA82 CERS4

Reference Transcript

Other Identifiers

11732516_a_at

11754372_x_at

16857851

218922_3p_s_at

218922_PM_s_at

218922_s_at

3819402

3819405

3819419

3819421

3819422

3819423

3819425

3819426

3819427

3819428

3819433

3819434

3819435

3819436

52955_at

79603

8025382

A_14_P132182

A_23_P153867

GE62791

GO:0003677

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0016020

GO:0016740

GO:0030148

GO:0043226

GO:0046513

GO:0050291

HMNXSV003011388

HMNXSV003022233

PH_hs_0015462

TC19000144.hg

g13375716_3p_a_at

g13375716_3p_x_at

Participates

as a member of

Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

crsA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

cers4 [endoplasmic reticulum membrane] (Xenopus tropicalis)

LAG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

schlank [endoplasmic reticulum membrane] (Drosophila melanogaster)

Homologues of CERS4 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Homologues of CERS4 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of CERS4 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

trh1 [endoplasmic reticulum membrane] (Danio rerio)

LAC1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

lag1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

lac1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

CERS4 [endoplasmic reticulum membrane] (Bos taurus)

CERS4 [endoplasmic reticulum membrane] (Canis familiaris)

CERS4 [endoplasmic reticulum membrane] (Gallus gallus)

CERS4 [endoplasmic reticulum membrane] (Plasmodium falciparum)

CERS4 [endoplasmic reticulum membrane] (Sus scrofa)

Cers4 [endoplasmic reticulum membrane] (Mus musculus)

Cers4 [endoplasmic reticulum membrane] (Rattus norvegicus)

hyl-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

hyl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011526596.1, XP_016882793.1, XP_011526594.1, XP_016882794.1, XP_011526597.1, NP_078828.2, XP_011526592.1, XP_011526595.1, XP_016882792.1, XP_011526593.1

Guide to Pharmacology - Targets

2477

OpenTargets

ENSG00000090661

IntEnz

2.3.1.24

HPA

ENSG00000090661-CERS4

GeneCards

Q9HA82

Ensembl

ENST00000251363, ENST00000559450, ENSP00000251363, ENSG00000090661, ENSP00000453509

PRO

Q9HA82

Pharos - Targets

Q9HA82

Orphanet

28109

HMDB Protein

HMDBP11632

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78382 SLC35A1	2	SLC35A1 [Golgi membrane] (R-HSA-727812) SLC35A1 V93Cfs*17 [Golgi membrane] (R-HSA-5651957)	0.556	3
UniProt:Q9UKG4 SLC13A4	1	SLC13A4 [plasma membrane] (R-HSA-433098)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478) IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3

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