Reactome | TPCN2 [lysosomal membrane]

TPCN2 [lysosomal membrane]

Stable Identifier

R-HSA-2685518

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Two pore calcium channel protein 2, TPC2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8NHX9 TPCN2

Gene Names

TPCN2, TPC2

Chain

chain:1-752

Reference Genes

BioGPS Gene:219931 TPCN2

COSMIC (genes):TPCN2 TPCN2

CTD Gene:219931 TPCN2

dbSNP Gene:219931 TPCN2

ENSEMBL:ENSG00000162341 TPCN2

ENSEMBL_homo_sapiens_GENE:ENSG00000162341.18 TPCN2

HGNC:20820 TPCN2

KEGG Gene (Homo sapiens):219931 TPCN2

Monarch:219931 TPCN2

NCBI Gene:219931 TPCN2

OMIM:612163 TPCN2

UCSC:Q8NHX9 TPCN2

Reference Transcript

RefSeq:NM_139075.3 TPCN2

Other Identifiers

11736835_at

11736836_at

11736837_a_at

16728189

219931

229250_PM_at

229250_at

229251_PM_s_at

229251_s_at

235194_PM_at

235194_at

242554_PM_at

242554_at

3337919

3337920

3337921

3337924

3337926

3337927

3337928

3337933

3337934

3337936

3337945

3337948

3337952

3337954

3337955

3337956

3337957

3337958

3337963

3337965

3337966

3337968

3337972

3337975

3337976

3337978

3337979

3337981

3337982

3337983

3337984

3337985

3337986

3337987

3337988

3337989

3337990

3337991

3337992

3337993

3337994

3337995

48977_s_at

54226_at

71261_at

7942091

87363_at

89383_at

A_14_P112656

A_23_P98159

A_33_P3264612

GE80377

GE853897

GE87504

GO:0003012

GO:0005215

GO:0005216

GO:0005245

GO:0005262

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005829

GO:0006811

GO:0006816

GO:0006874

GO:0006914

GO:0006939

GO:0007040

GO:0008289

GO:0010008

GO:0010506

GO:0015280

GO:0016020

GO:0016192

GO:0017157

GO:0019065

GO:0019722

GO:0019901

GO:0022832

GO:0023052

GO:0031410

GO:0031902

GO:0033162

GO:0033280

GO:0034220

GO:0034702

GO:0035725

GO:0036020

GO:0042802

GO:0043226

GO:0048086

GO:0051209

GO:0051452

GO:0055065

GO:0055085

GO:0070588

GO:0072345

GO:0075509

GO:0080025

GO:0090117

GO:0097682

HMNXSV003008523

HMNXSV003011538

HMNXSV003041770

HMNXSV003051114

Hs.288748.0.S1_3p_at

Hs.288748.0.S1_3p_x_at

Hs.301371.0.A1_3p_at

Hs.301371.1.A1_3p_at

ILMN_1726873

PH_hs_0010931

TC11000714.hg

Participates

as a member of

TPCN1/2 [lysosomal membrane] (Homo sapiens)

Inferred To

TPCN2 [lysosomal membrane] (Bos taurus)

TPCN2 [lysosomal membrane] (Canis familiaris)

TPCN2 [lysosomal membrane] (Gallus gallus)

TPCN2 [lysosomal membrane] (Sus scrofa)

Tpcn2 [lysosomal membrane] (Mus musculus)

Tpcn2 [lysosomal membrane] (Rattus norvegicus)

tpcn2 [lysosomal membrane] (Danio rerio)

tpcn2 [lysosomal membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_620714.2

Guide to Pharmacology - Targets

393

OpenTargets

ENSG00000162341

GeneCards

Q8NHX9

HPA

ENSG00000162341-TPCN2

Ensembl

ENSP00000294309, ENSG00000162341, ENST00000294309

PRO

Q8NHX9

Pharos - Targets

Q8NHX9

HMDB Protein

HMDBP08069

PDB

6NQ0, 6NQ1, 6NQ2

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.527	2
UniProt:Q8TCT0 CERK	1	CERK [plasma membrane] (R-HSA-1631584)	0.527	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.527	2
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.527	2
UniProt:P51790 CLCN3	1	CLCN3 [late endosome membrane] (R-HSA-2671918)	0.527	2
UniProt:Q9UJK0 TSR3	1	TSR3 [cytosol] (R-HSA-8868776)	0.527	2
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.527	2
UniProt:Q9NPF0 CD320	2	CD320 [plasma membrane] (R-HSA-2980909) CD320 E88del [plasma membrane] (R-HSA-3325560)	0.527	2
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.527	2

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