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FBXL5 [cytosol]
Stable Identifier
R-HSA-391295
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FBL4/FBL5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
CUL1, SKP1, FBXL5 bind (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKA1 FBXL5
Gene Names
FBXL5, FBL4, FBL5, FLR1
Chain
chain:1-691
Reference Genes
BioGPS Gene:26234 FBXL5
COSMIC (genes):FBXL5 FBXL5
CTD Gene:26234 FBXL5
dbSNP Gene:26234 FBXL5
ENSEMBL:ENSG00000118564 FBXL5
ENSEMBL_homo_sapiens_GENE:ENSG00000118564.15 FBXL5
HGNC:13602 FBXL5
KEGG Gene (Homo sapiens):26234 FBXL5
Monarch:26234 FBXL5
NCBI Gene:26234 FBXL5
OMIM:605655 FBXL5
UCSC:Q9UKA1 FBXL5
Reference Transcript
RefSeq:NM_012161.3 FBXL5
RefSeq:NM_001193534.1 FBXL5
RefSeq:NM_001193535.1 FBXL5
Other Identifiers
11721315_s_at
11746161_s_at
16974498
209004_PM_s_at
209004_s_at
209005_PM_at
209005_at
26234
2761733
2761735
2761736
2761737
2761738
2761739
2761743
2761747
2761748
2761749
2761750
2761752
2761753
2761757
2761758
2761759
2761762
2761763
2761766
2761767
2761768
41801_at
8099449
A_23_P213247
GE55376
GO:0000151
GO:0003824
GO:0004842
GO:0005506
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006879
GO:0016567
GO:0016740
GO:0019005
GO:0030163
GO:0031146
GO:0036211
GO:0043226
GO:0045732
GO:0046872
GO:0048471
GO:0051536
GO:0051537
GO:0055065
GO:0055080
GO:0060586
GO:0098771
GO:0140096
HMNXSV003053328
ILMN_1673370
ILMN_2378100
PH_hs_0000570
TC04001057.hg
TC04002474.hg
g7672733_3p_a_at
g7688696_3p_at
Participates
as a candidate of
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
as an input of
CUL1, SKP1, FBXL5 bind (Homo sapiens)
as a component of
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
as a member of
F-box protein [cytosol] (Homo sapiens)
Inferred To
Fbxl5 [cytosol]
(Rattus norvegicus)
FBXL5 [cytosol]
(Bos taurus)
FBXL5 [cytosol]
(Canis familiaris)
FBXL5 [cytosol]
(Danio rerio)
FBXL5 [cytosol]
(Gallus gallus)
FBXL5 [cytosol]
(Mus musculus)
FBXL5 [cytosol]
(Plasmodium falciparum)
FBXL5 [cytosol]
(Saccharomyces cerevisiae)
FBXL5 [cytosol]
(Sus scrofa)
Ghost homologue of FBXL5 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of FBXL5 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of FBXL5 [cytosol]
(Drosophila melanogaster)
Ghost homologue of FBXL5 [cytosol]
(Xenopus tropicalis)
Homologues of FBXL5 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001180464.1
,
NP_001180463.1
,
NP_036293.1
OpenTargets
ENSG00000118564
HPA
ENSG00000118564-FBXL5
GeneCards
Q9UKA1
Ensembl
ENSP00000344866
,
ENSG00000118564
,
ENSP00000408679
,
ENST00000341285
,
ENST00000412094
PRO
Q9UKA1
Pharos - Targets
Q9UKA1
PDB
3V5Z
,
3V5X
,
3U9J
,
6VCD
,
3U9M
,
3V5Y
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.871
13
UniProt:Q13148 TADBP
0.556
3
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.527
2
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.527
2
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