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FBXL5 [cytosol]
Stable Identifier
R-HSA-391295
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FBL4/FBL5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
CUL1, SKP1, FBXL5 bind (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Homo sapiens)
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
FBXL5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKA1 FBXL5
Gene Names
FBXL5, FBL4, FBL5, FLR1
Chain
chain:1-691
Reference Genes
BioGPS Gene:26234 FBXL5
COSMIC (genes):FBXL5 FBXL5
CTD Gene:26234 FBXL5
dbSNP Gene:26234 FBXL5
ENSEMBL:ENSG00000118564 FBXL5
HGNC:13602 FBXL5
KEGG:hsa:26234 FBXL5
Monarch:26234 FBXL5
NCBI Gene:26234 FBXL5
OMIM:605655 FBXL5
UCSC:Q9UKA1 FBXL5
Reference Transcript
RefSeq:NM_001193535.1 FBXL5
RefSeq:NM_001193534.1 FBXL5
RefSeq:NM_012161.3 FBXL5
Other Identifiers
11721315_s_at
11746161_s_at
16974498
209004_PM_s_at
209004_s_at
209005_PM_at
209005_at
26234
2761733
2761735
2761736
2761737
2761738
2761739
2761743
2761747
2761748
2761749
2761750
2761752
2761753
2761755
2761756
2761757
2761758
2761759
2761760
2761762
2761763
2761766
2761767
2761768
2761782
2761783
2761784
2761785
2761786
41801_at
8099449
A_19_P00315808
A_19_P00318057
A_19_P00318551
A_19_P00318998
A_19_P00320816
A_19_P00320983
A_19_P00321324
A_19_P00321572
A_19_P00321593
A_19_P00321594
A_19_P00322189
A_19_P00322431
A_19_P00322493
A_19_P00322726
A_19_P00322727
A_19_P00322955
A_23_P213247
A_32_P108748
GE55376
GO:0000151
GO:0003824
GO:0004842
GO:0005506
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006879
GO:0016567
GO:0016740
GO:0019005
GO:0030163
GO:0031146
GO:0043226
GO:0045732
GO:0046872
GO:0048471
GO:0051537
GO:0060586
GO:0098771
GO:0140096
HMNXSV003004627
HMNXSV003053328
ILMN_1673370
ILMN_1735051
ILMN_2378100
PH_hs_0000570
TC04001057.hg
TC04002474.hg
g7672733_3p_a_at
g7688696_3p_at
p25298
Participates
as a candidate of
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
as a component of
SKP1:CUL1:FBXL5 [cytosol] (Homo sapiens)
as an input of
CUL1, SKP1, FBXL5 bind (Homo sapiens)
as a member of
F-box protein [cytosol] (Homo sapiens)
Inferred To
Fbxl5 [cytosol]
(Rattus norvegicus)
FBXL5 [cytosol]
(Bos taurus)
FBXL5 [cytosol]
(Canis familiaris)
FBXL5 [cytosol]
(Danio rerio)
FBXL5 [cytosol]
(Gallus gallus)
FBXL5 [cytosol]
(Mus musculus)
FBXL5 [cytosol]
(Plasmodium falciparum)
FBXL5 [cytosol]
(Saccharomyces cerevisiae)
FBXL5 [cytosol]
(Sus scrofa)
Ghost homologue of FBXL5 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of FBXL5 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of FBXL5 [cytosol]
(Drosophila melanogaster)
Ghost homologue of FBXL5 [cytosol]
(Xenopus tropicalis)
Homologues of FBXL5 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_036293.1
,
NP_001180463.1
,
NP_001180464.1
OpenTargets
ENSG00000118564
ENSEMBL
ENST00000412094
,
ENSP00000408679
,
ENST00000341285
,
ENSP00000344866
HPA
ENSG00000118564-FBXL5
PRO
Q9UKA1
Pharos - Targets
Q9UKA1
PDB
6VCD
,
3V5Z
,
3U9J
,
3V5Y
,
3U9M
,
3V5X
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.905
15
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.643
4
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.643
4
UniProt:O95714 HERC2
5
HERC2 [nucleoplasm]
(R-HSA-4551680)
p-T4827-HERC2 [nucleoplasm]
(R-HSA-5682601)
p-T4827,SUMO1-HERC2 [nucleoplasm]
(R-HSA-5682615)
HERC2 [cytosol]
(R-HSA-975975)
monoSUMO1-HERC2 [nucleoplasm]
(R-HSA-4551758)
0.623
4
UniProt:Q13148 TADBP
0.556
3
UniProt:Q9BQ90 KLHDC3
1
KLHDC3 [cytosol]
(R-HSA-535552)
0.527
2
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.527
2
UniProt:Q92624 APBP2
0.527
2
UniProt:O76071 CIAO1
1
CIAO1 [cytosol]
(R-HSA-2161126)
0.527
3
UniProt:Q9UNS2 COPS3
2
COPS3 [nucleoplasm]
(R-HSA-5697017)
COPS3 [cytosol]
(R-HSA-416973)
0.527
2
UniProt:Q562R1 ACTBL
0.527
2
UniProt:P28676 GCA
2
GCA [extracellular region]
(R-HSA-6806174)
GCA [azurophil granule lumen]
(R-HSA-6799167)
0.527
2
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.527
3
UniProt:Q9Y3D0 CIAO2B
1
FAM96B [cytosol]
(R-HSA-2161124)
0.527
3
UniProt:Q9H2Y7 ZN106
0.527
2
UniProt:Q96T76 MMS19
1
MMS19 [cytosol]
(R-HSA-2161121)
0.527
3
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