Reactome | LRRC14 [cytosol]

LRRC14 [cytosol]

Stable Identifier

R-HSA-9749455

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Leucine-rich repeat-containing protein 14

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        LRRC14 binds IKBKB and CHUK (Homo sapiens)
        
        CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)
        
        LRRC14 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15048 LRRC14

Gene Names

LRRC14, KIAA0014

Chain

chain:1-493

Reference Genes

BioGPS Gene:9684 LRRC14

COSMIC (genes):LRRC14 LRRC14

CTD Gene:9684 LRRC14

dbSNP Gene:9684 LRRC14

ENSEMBL:ENSG00000160959 LRRC14

ENSEMBL_homo_sapiens_GENE:ENSG00000160959.8 LRRC14

HGNC:20419 LRRC14

KEGG Gene (Homo sapiens):9684 LRRC14

Monarch:9684 LRRC14

NCBI Gene:9684 LRRC14

OMIM:619368 LRRC14

UCSC:Q15048 LRRC14

Reference Transcript

Other Identifiers

11720735_s_at

11720736_a_at

11747733_a_at

17073919

203495_3p_at

203495_PM_at

203495_at

3120700

3120704

3120706

3120707

3120708

3120710

3120711

3120712

3120713

3120714

3120715

3120716

3120717

3120718

3120719

3120720

3120722

3120724

3120726

3120728

3120730

3120732

3120734

3120736

32062_PM_at

32062_at

8148923

9684

A_14_P138916

A_23_P134946

D25216_at

GE57121

GO:0002376

GO:0005515

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0019900

GO:0023052

GO:0032088

GO:0034122

GO:0098542

HMNXSV003017809

HMNXSV003021271

ILMN_1678998

PH_hs_0009378

TC08000858.hg

g7661859_3p_at

g7661859_3p_s_at

Participates

as a component of

CHUK:IKBKB:LRRC14 [cytosol] (Homo sapiens)

as an input of

LRRC14 binds IKBKB and CHUK (Homo sapiens)

Inferred To

Lrrc14 [cytosol] (Mus musculus)

Lrrc14 [cytosol] (Rattus norvegicus)

LRRC14 [cytosol] (Bos taurus)

LRRC14 [cytosol] (Canis familiaris)

LRRC14 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_055480.1, NP_001258965.1, XP_005272415.1, XP_005272416.1

OpenTargets

ENSG00000160959

GeneCards

Q15048

HPA

ENSG00000160959-LRRC14

Ensembl

ENSG00000160959, ENSP00000434768, ENST00000529022, ENSP00000292524, ENST00000292524

PRO

Q15048

Pharos - Targets

Q15048

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982)	0.623	7
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.564	3
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.564	5

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