Reactome | LMNA-2 [nuclear envelope]

LMNA-2 [nuclear envelope]

Stable Identifier

R-HSA-912378

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

Lamin-C, Lamin-A/C, LMNA_HUMAN, LMNA isoform 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02545-2 LMNA

Gene Names

LMNA, LMN1

Other Identifiers

11719260_x_at

11719261_s_at

11752340_x_at

11752506_s_at

11752507_x_at

11752673_x_at

11762162_x_at

1554600_PM_s_at

1554600_s_at

16671914

203411_PM_s_at

203411_s_at

212086_PM_x_at

212086_x_at

212089_PM_at

212089_at

214213_PM_x_at

214213_x_at

2361280

2361281

2361282

2361283

2361284

2361286

2361287

2361288

2361294

2361295

2361298

2361299

2361300

2361301

2361302

2361303

2361308

2361309

2361310

2361311

2361312

2361313

2361314

2361315

2361316

2361317

2361318

2361319

2361320

2361321

2361322

2361323

2361324

2361325

2361326

2361327

2361328

2361329

2361330

2361331

2361332

2361333

2361334

2361335

2361336

2361337

2361338

244225_PM_x_at

244225_x_at

37377_i_at

37378_r_at

4000

65399_i_at

65400_r_at

71744_at

71746_s_at

7906085

A_14_P114205

A_23_P34835

A_24_P162718

A_33_P3311285

A_33_P3408762

GE81529

GE85803

GO:0005198

GO:0005200

GO:0005515

GO:0005634

GO:0005635

GO:0005638

GO:0005652

GO:0005654

GO:0005829

GO:0005882

GO:0006325

GO:0006606

GO:0006886

GO:0006913

GO:0006997

GO:0006998

GO:0007010

GO:0007097

GO:0007163

GO:0007517

GO:0008104

GO:0008285

GO:0010628

GO:0016363

GO:0016607

GO:0030334

GO:0030951

GO:0031507

GO:0031647

GO:0031965

GO:0032204

GO:0034504

GO:0035861

GO:0042802

GO:0043226

GO:0048471

GO:0048856

GO:0051664

GO:0055015

GO:0061024

GO:0071456

GO:0072201

GO:0090201

GO:0090398

GO:0090435

GO:0160123

GO:1900180

GO:1903243

GO:1990683

GO:2001237

HMNXSV003021995

HMNXSV003040267

HMNXSV003043843

HMNXSV003044458

Hs.181904.0.A1_3p_at

Hs.77886.1.S1_3p_a_at

Hs.77886.2.S2_3p_at

Hs2.377973.4.S1_3p_s_at

ILMN_1696749

ILMN_1737394

M13452_s_at

PH_hs_0025504

TC01001313.hg

g5031874_3p_a_at

Participates

as a component of

Telomere Attachment Plate [nuclear envelope] (Homo sapiens)

as an input of

Telomeres cluster at the nuclear membrane (Homo sapiens)

Other forms of this molecule

LMNA-2 [cytosol]

Lamin C [nucleoplasm]

p-S395-LMNA-2 [nucleoplasm]

p-S22, S395-LMNA-2 [nucleoplasm]

Cross References

RefSeq

NP_001269553.1, NP_005563.1, NP_733822.1, NP_733821.1, NP_001244303.1, NP_001269554.1, NP_001269555.1

OpenTargets

ENSG00000160789

ENSEMBL

ENSP00000357282, ENST00000677389, ENSP00000357283, ENSP00000502091, ENSP00000506771, ENSP00000357284, ENST00000682650, ENST00000675939, ENST00000448611, ENST00000368301, ENSP00000395597, ENST00000683032, ENSP00000502256, ENSP00000503633, ENSP00000355292, ENST00000368300, ENST00000368299, ENST00000676385, ENSP00000506904, ENST00000473598, ENSP00000421821, ENST00000361308

HPA

ENSG00000160789-LMNA

PRO

P02545

Pharos - Targets

P02545

GlyGen

P02545

Orphanet

LMNA

PDB

7WZZ, 7Z21, 6RPR, 6YJD, 3V4W, 3GEF, 1X8Y, 6GHD, 1IVT, 6YF5, 2YPT, 2XV5, 7X1B, 7YVD, 6JLB, 7X5D, 3V5B, 7CRG, 6SNZ, 1IFR, 7D9N, 3V4Q

Interactors (90)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.933	23
UniProt:Q03252 LMNB2			0.849	10
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.799	7
UniProt:Q9UII6 DS13B			0.781	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.774	23
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.723	5
UniProt:O75694 NUP155	2	NUP155 [cytosol] (R-HSA-9634170) NUP155 [nuclear envelope] (R-HSA-157690)	0.672	6
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.666	4
UniProt:P42166 TMPO			0.629	4
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.604	3
UniProt:Q0D2I5-5 IFFO1			0.576	4
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.569	5
UniProt:P42167 TMPO	1	TMPO [cytosol] (R-HSA-9714330)	0.569	4
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P62701 RPS4X	2	RPS4X [cytosol] (R-HSA-72375) RPS4X [nucleoplasm] (R-HSA-6798713)	0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
UniProt:Q9NWB1-5 RBFOX1			0.556	3
UniProt:Q14585 ZN345			0.556	3
UniProt:Q6ZNH5 ZN497			0.556	3
IntAct:EBI-25842396 CCSB			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q04323-2 UBXN1			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9BS31 ZNF649	1	ZNF649 [nucleoplasm] (R-HSA-2127585)	0.556	3
UniProt:O43309 ZSC12			0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q9Y4E8-2 USP15			0.556	3
UniProt:Q96EL1 INKA1			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q6H8Q1-8 ABLIM2			0.556	3
UniProt:Q9BZ95-3 Q9BZ953			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:A6H8Z2-3 A6H8Z23			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q99612 KLF6			0.556	3
UniProt:Q96GN5-2 CDCA7L			0.556	3
UniProt:Q96KP6 TNIP3	1	TNIP3 [cytosol] (R-HSA-561192)	0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q12986 NFX1			0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q03181-2 PPARD			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:Q8TCX5 RHPN1	1	RHPN1 [cytosol] (R-HSA-5667017)	0.556	3
UniProt:Q8TBZ8 ZNF564	1	ZNF564 [nucleoplasm] (R-HSA-1973885)	0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.556	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q8WW38 ZFPM2	1	ZFPM2 [nucleoplasm] (R-HSA-996726)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.556	3
IntAct:EBI-25851697 CCSB			0.556	3
UniProt:Q3SX64 CMA1D			0.556	3
UniProt:Q6ZN57 ZFP2	1	ZFP2 [nucleoplasm] (R-HSA-975018)	0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.556	3
UniProt:Q13133-3 NR1H3			0.556	3
UniProt:P10074 TZAP			0.556	3
UniProt:P58499 FAM3B			0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:P10073 ZSC22			0.556	3
UniProt:Q6ZNE9 RUFY4			0.556	3
UniProt:Q9D666 Sun1	1	Sun1 [nuclear envelope] (R-MMU-912375)	0.528	2
UniProt:O75531 BANF1	4	p-T2,T3,S4-BANF1 [cytosol] (R-HSA-2995375) BANF1 [cytosol] (R-HSA-175371) BANF1 [nucleoplasm] (R-HSA-175030) p-T2,T3,S4-BANF1 [nucleoplasm] (R-HSA-2993896)	0.527	2
UniProt:P17029 ZKSCAN1	1	ZKSCAN1 [nucleoplasm] (R-HSA-975013)	0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	3
UniProt:P18054 ALOX12	1	ALOX12 [cytosol] (R-HSA-2142768)	0.508	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.491	2
UniProt:O75937 DNAJC8	1	DNAJC8 [nucleoplasm] (R-HSA-53703)	0.483	3
UniProt:Q9H2H8 PPIL3	1	PPIL3 [nucleoplasm] (R-HSA-8952110)	0.483	2
UniProt:Q8WXH0-1 SYNE2			0.463	3

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