Reactome | p-Y254-RHOU [plasma membrane]

p-Y254-RHOU [plasma membrane]

Stable Identifier

R-HSA-9726857

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y254-Wrch-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q7L0Q8 RHOU

Gene Names

RHOU, ARHU, CDC42L1, G28K, WRCH1, SB128

Chain

chain:1-258

Reference Genes

BioGPS Gene:58480 RHOU

COSMIC (genes):RHOU RHOU

CTD Gene:58480 RHOU

dbSNP Gene:58480 RHOU

ENSEMBL:ENSG00000116574 RHOU

ENSEMBL_homo_sapiens_GENE:ENSG00000116574.6 RHOU

ENSEMBL_homo_sapiens_GENE:ENSG00000284984.2 RHOU

HGNC:17794 RHOU

KEGG Gene (Homo sapiens):58480 RHOU

Monarch:58480 RHOU

NCBI Gene:58480 RHOU

OMIM:606366 RHOU

UCSC:Q7L0Q8 RHOU

Reference Transcript

RefSeq:NM_021205.5 RHOU

Other Identifiers

11717416_a_at

11717417_s_at

16678518

223168_PM_at

223168_at

223169_PM_s_at

223169_s_at

2384410

2384411

2384412

2384413

2384414

2384420

2384421

2384422

2384423

45289_at

58480

7910387

91992_at

A_14_P201415

A_23_P114814

A_24_P62530

GE55805

GO:0000082

GO:0000139

GO:0000166

GO:0000278

GO:0002102

GO:0003824

GO:0003924

GO:0005085

GO:0005515

GO:0005525

GO:0005768

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006886

GO:0006897

GO:0007005

GO:0007010

GO:0007015

GO:0007163

GO:0007264

GO:0008360

GO:0010008

GO:0016020

GO:0016192

GO:0016601

GO:0016787

GO:0019901

GO:0023052

GO:0030036

GO:0031410

GO:0032488

GO:0042995

GO:0043226

GO:0046872

GO:0048856

GO:0051056

GO:0070161

GO:0098772

GO:1903955

HMNXSV003007370

Hs.20252.0.A2_3p_at

PH_hs_0001762

TC01006343.hg

g11527796_3p_a_at

p33650

Participates

as a component of

p-Y254-RHOU:GDP [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y254-RHOU [endosome membrane]

RHOU [plasma membrane]

RHOU [cytosol]

Inferred To

phospho-chw-1 [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y254-RHOU [plasma membrane] (Bos taurus)

phospho-p-Y254-RHOU [plasma membrane] (Dictyostelium discoideum)

phospho-p-Y254-RHOU [plasma membrane] (Gallus gallus)

phospho-p-Y254-RHOU [plasma membrane] (Mus musculus)

phospho-p-Y254-RHOU [plasma membrane] (Saccharomyces cerevisiae)

phospho-p-Y254-RHOU [plasma membrane] (Schizosaccharomyces pombe)

phospho-RHOU [plasma membrane] (Canis familiaris)

phospho-RHOU [plasma membrane] (Sus scrofa)

phospho-RhoU [plasma membrane] (Drosophila melanogaster)

phospho-rhou [plasma membrane] (Xenopus tropicalis)

phospho-rhoua [plasma membrane] (Danio rerio)

Homologues of p-Y254-RHOU [plasma membrane] (Saccharomyces cerevisiae)

phospho-Rhou [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 254

Coordinate

254

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_067028.1

OpenTargets

ENSG00000116574

HPA

ENSG00000116574-RHOU

GeneCards

Q7L0Q8

Ensembl

ENSG00000284984, ENSP00000355652, ENST00000366691, ENSP00000494673, ENST00000646945, ENSG00000116574

PRO

Q7L0Q8

Pharos - Targets

Q7L0Q8

PDB

2Q3H

HMDB Protein

HMDBP09122

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.787	6
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.589	3
UniProt:Q14289 PTK2B	3	p-Y-PTK2B [cytosol] (R-HSA-508515) PTK2B [cytosol] (R-HSA-390932) PTK2B [cytosol] (R-HSA-5218721)	0.581	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.524	3