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RIT1 [plasma membrane]
Stable Identifier
R-HSA-187703
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GTP-binding protein Rit1, RIT1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to p38 via RIT and RIN (Homo sapiens)
RIT/RIN are activated (Homo sapiens)
Active Trk receptor complex:RIT/RIN-GTP [plasma membrane] (Homo sapiens)
RIT/RIN-GTP [plasma membrane] (Homo sapiens)
RIT/RIN [plasma membrane] (Homo sapiens)
RIT1 [plasma membrane] (Homo sapiens)
Active TrkA receptor complex:RIT/RIN-GDP [plasma membrane] (Homo sapiens)
RIT/RIN-GDP [plasma membrane] (Homo sapiens)
RIT/RIN [plasma membrane] (Homo sapiens)
RIT1 [plasma membrane] (Homo sapiens)
RIT/RIN-GTP binds B-RAF (Homo sapiens)
Active Trk receptor complex:RIT/RIN-GTP [plasma membrane] (Homo sapiens)
RIT/RIN-GTP [plasma membrane] (Homo sapiens)
RIT/RIN [plasma membrane] (Homo sapiens)
RIT1 [plasma membrane] (Homo sapiens)
Active Trk receptor complex:RIT/RIN-GTP:B-RAF [plasma membrane] (Homo sapiens)
RIT/RIN-GTP [plasma membrane] (Homo sapiens)
RIT/RIN [plasma membrane] (Homo sapiens)
RIT1 [plasma membrane] (Homo sapiens)
TRKA recruits RIT and RIN (Homo sapiens)
Active TrkA receptor complex:RIT/RIN-GDP [plasma membrane] (Homo sapiens)
RIT/RIN-GDP [plasma membrane] (Homo sapiens)
RIT/RIN [plasma membrane] (Homo sapiens)
RIT1 [plasma membrane] (Homo sapiens)
RIT/RIN-GDP [plasma membrane] (Homo sapiens)
RIT/RIN [plasma membrane] (Homo sapiens)
RIT1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92963 RIT1
Gene Names
RIT1, RIBB, RIT, ROC1
Chain
chain:1-219
Reference Genes
BioGPS Gene:6016 RIT1
COSMIC (genes):RIT1 BCL11B
CTD Gene:6016 RIT1
dbSNP Gene:6016 RIT1
ENSEMBL:ENSG00000143622 RIT1
HGNC:10023 RIT1
KEGG:hsa:6016 RIT1
Monarch:6016 RIT1
NCBI Gene:6016 RIT1
OMIM:609591 RIT1
UCSC:Q92963 RIT1
Reference Transcript
RefSeq:NM_001256820.1 RIT1
RefSeq:NM_001256821.1 RIT1
RefSeq:NM_006912.5 RIT1
Other Identifiers
11725077_at
11725078_at
11725079_a_at
16694322
209882_PM_at
209882_at
239843_PM_at
239843_at
243463_PM_s_at
243463_s_at
2437733
2437735
2437737
2437738
2437739
2437740
2437741
2437746
2437747
2437748
2437749
2437750
38331_at
6016
74221_at
7920839
A_23_P115052
A_23_P316601
A_33_P3394075
GE60240
GO:0000166
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005516
GO:0005525
GO:0005886
GO:0007165
GO:0007265
GO:0016020
GO:0016787
GO:0019003
GO:0098772
HMNXSV003007447
Hs.128079.0.A1_3p_at
Hs.48401.1.A1_3p_at
ILMN_1656335
TC01003324.hg
U71203_s_at
Y07566_at
g4234917_3p_at
Participates
as a member of
RIT/RIN [plasma membrane] (Homo sapiens)
Cross References
ENSEMBL
ENSP00000357306
,
ENSP00000357305
,
ENST00000539040
,
ENSP00000441950
,
ENST00000368323
,
ENST00000368322
,
ENSG00000143622
OpenTargets
ENSG00000143622
IntEnz
3.6.5.2
GeneCards
RIT1
HPA
ENSG00000143622-RIT1
PRO
Q92963
Pharos - Targets
Q92963
Orphanet
RIT1
HMDB Protein
HMDBP08559
PDB
4KLZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
0.619
5
UniProt:P60953 CDC42
3
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.619
6
UniProt:Q13153 PAK1
5
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
PAK1 [cytosol]
(R-HSA-162629)
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [plasma membrane]
(R-HSA-3928409)
0.619
4
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