Formation of PPARG:RXRA heterodimer (ARF6 complex)

Stable Identifier
R-HSA-381262
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of PPARG:RXRA heterodimer (ARF6 complex)
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PPARG binds the Retinoic acid X Receptor RXRA to form a heterodimer that has transcriptional acivation activity. The complex was initially called ARF6 when discovered. PPARG binds RXRA via the C-terminus and AF-2 regions of PPARG.
Literature References
PubMed ID Title Journal Year
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
17980149 Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution

Li, E, Stanley, SE, Chen, M, Lu, J

Biochem Biophys Res Commun 2008
19043829 Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

Chandra, V, Huang, P, Hamuro, Y, Wang, Y, Burris, TP, Raghuram, S, Rastinejad, F

Nature 2008
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Orthologous Events
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Bos taurus)
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Formation of PPARG:RXRA heterodimer (ARF6 complex) (Danio rerio)
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Drosophila melanogaster)
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Gallus gallus)
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Mus musculus)
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Rattus norvegicus)
Formation of PPARG:RXRA heterodimer (ARF6 complex) (Sus scrofa)
Authored
May, B  (2009-05-15)
Reviewed
Sethi, JK  (2011-02-10)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2008-11-20)
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