Reactome | NR1H2 [nucleoplasm]

NR1H2 [nucleoplasm]

Stable Identifier

R-HSA-375500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NR1H2_HUMAN, Oxysterols receptor LXR-beta

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ABCA1 (Homo sapiens)
        
        ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        NR1H2,3:RXR [nucleoplasm] (Homo sapiens)
        
        NR1H2:RXRA [nucleoplasm] (Homo sapiens)
        
        NR1H2 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)
        
        NR1H2:hydroxycholesterol [nucleoplasm] (Homo sapiens)
        
        NR1H2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55055 NR1H2

Gene Names

NR1H2, LXRB, NER, UNR

Chain

chain:1-460

Reference Genes

BioGPS Gene:7376 NR1H2

COSMIC (genes):NR1H2 NR1H2

CTD Gene:7376 NR1H2

dbSNP Gene:7376 NR1H2

ENSEMBL:ENSG00000131408 NR1H2

HGNC:7965 NR1H2

KEGG:hsa:7376 NR1H2

Monarch:7376 NR1H2

NCBI Gene:7376 NR1H2

OMIM:600380 NR1H2

UCSC:P55055 NR1H2

Reference Transcript

Other Identifiers

11748768_x_at

11751235_a_at

11757339_x_at

16864472

218215_PM_s_at

218215_s_at

3839277

3839278

3839279

3839280

3839283

3839284

3839285

3839286

3839287

3839288

3839289

3839290

3839291

3839292

3839293

3839294

3839295

3839296

3839297

3839298

3839299

3839300

3839301

3839302

3839303

3839304

518_at

519_g_at

7376

8030630

A_23_P55926

A_23_P67332

A_33_P3356637

GE58888

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0008270

GO:0009755

GO:0010745

GO:0010867

GO:0010875

GO:0010884

GO:0010887

GO:0016071

GO:0030154

GO:0030522

GO:0031490

GO:0032369

GO:0032376

GO:0034191

GO:0036151

GO:0042632

GO:0042789

GO:0043226

GO:0043565

GO:0044255

GO:0045723

GO:0045861

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0046965

GO:0048550

GO:0051006

GO:0051117

GO:0051247

GO:0055088

GO:0060089

GO:0060336

GO:0090108

GO:0090187

GO:0090340

GO:0090575

GO:0120163

GO:0140110

GO:1902895

GO:1903573

HMNXSV003054082

ILMN_1678032

PH_hs_0028409

TC19000756.hg

U07132_at

g11321629_3p_a_at

Participates

as a component of

as a member of

Other forms of this molecule

polySUMO2,3-K409,K447-NR1H2 [nucleoplasm]

NR1H2 [cytosol]

Inferred To

NR1H2 [nucleoplasm] (Bos taurus)

NR1H2 [nucleoplasm] (Canis familiaris)

NR1H2 [nucleoplasm] (Sus scrofa)

EcR [nucleoplasm] (Drosophila melanogaster)

nr1h2 [nucleoplasm] (Xenopus tropicalis)

Nr1h2 [nucleoplasm] (Mus musculus)

Nr1h2 [nucleoplasm] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

601

OpenTargets

ENSG00000131408

ENSEMBL

ENSP00000253727, ENST00000652203, ENSP00000396151, ENST00000593926, ENSP00000499121, ENSP00000471194, ENST00000411902, ENST00000253727

HPA

ENSG00000131408-NR1H2

ZINC - Substances

NR1H2_HUMAN

ZINC - Biogenic

NR1H2_HUMAN

ZINC target

P55055

PRO

P55055

Pharos - Targets

P55055

GlyGen

P55055

ZINC - Predictions - Purchasable

NR1H2_HUMAN

PDB

5I4V, 4DK8, 4DK7, 6K9H, 6S4U, 6K9M, 1PQC, 5KYA, 5KYJ, 6S5K, 1UPW, 1UPV, 3L0E, 1P8D, 6JIO, 3KFC, 5HJP, 6S4T, 1PQ9, 1PQ6, 4RAK, 6K9G, 6S4N, 4NQA, 5JY3

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.592	3
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.525	6

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