SUMOylation of RXRA with SUMO1

Stable Identifier
R-HSA-4341048
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of RXRA with SUMO1
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RXRA (Retinoid X receptor alpha) is SUMOylated at lysine-108 with SUMO1 (Choi et al. 2006). SUMOylation represses transcription activation by RXRA.

Literature References
PubMed ID Title Journal Year
16912044 Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1

Lee, MH, Chung, SS, Seol, JH, Lee, HW, Baek, SH, Choi, SJ, Bang, OS, Choi, HS, Chung, CH, Rho, EJ

J. Biol. Chem. 2006
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of RXRA with SUMO1 (Bos taurus)
SUMOylation of RXRA with SUMO1 (Danio rerio)
SUMOylation of RXRA with SUMO1 (Gallus gallus)
SUMOylation of RXRA with SUMO1 (Mus musculus)
SUMOylation of RXRA with SUMO1 (Rattus norvegicus)
SUMOylation of RXRA with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-08-14)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-19)
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