Reactome | monoSUMO1-K107,K395-PPARG [nucleoplasm]

monoSUMO1-K107,K395-PPARG [nucleoplasm]

Stable Identifier

R-HSA-4717444

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor gamma, PPARG_HUMAN

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External Reference Information

External Reference

UniProt:P37231 PPARG

Gene Names

PPARG, NR1C3

Chain

chain:1-505

Reference Genes

BioGPS Gene:5468 PPARG

COSMIC (genes):PPARG PPARG

CTD Gene:5468 PPARG

dbSNP Gene:5468 PPARG

ENSEMBL:ENSG00000132170 PPARG

HGNC:9236 PPARG

KEGG:hsa:5468 PPARG

Monarch:5468 PPARG

NCBI Gene:5468 PPARG

OMIM:601487 PPARG

UCSC:P37231 PPARG

Reference Transcript

Participates

as an output of

PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)

Other forms of this molecule

PPARG [nucleoplasm]

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 107

Coordinate

107

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 395

Coordinate

395

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_619725.2, NP_005028.4, NP_056953.2, NP_619726.2, XP_011532143.1

ZINC - World Drugs

PPARG_HUMAN

Guide to Pharmacology - Targets

595

OpenTargets

ENSG00000132170

ENSEMBL

ENSP00000287820, ENSG00000132170, ENST00000287820

ZINC - FDA approved

PPARG_HUMAN

ZINC - Substances

PPARG_HUMAN

ZINC - Biogenic

PPARG_HUMAN

ZINC target

P37231

PRO

P37231

GlyGen

P37231

PDB

3PO9, 2ATH, 7WGP, 1ZEO, 3WJ4, 3TY0, 7AWC, 4HEE, 3VSO, 3AN4, 8B92, 7E2O, 2FVJ, 7CXL, 6FZY, 6FZG, 5AZV, 5DVC, 2GTK, 4L96, 3T03, 2Q59, 6TDC, 3CDS, 7CXJ, 5Y2O, 3ADT, 2ZVT, 2Q5S, 8ZFS, 8DKV, 6JF0, 6IZM, 6ONI, 6AD9, 4R6S, 3IA6, 2VV4, 4OJ4, 1PRG, 7WGO, 7AWD, 1I7I, 5GTN, 8AQN, 6DGL, 6JQ7, 8B91, 5DWL, 3AN3, 4O8F, 8WFE, 3R8A, 6VZN, 5F9B, 2Q8S, 6D8X, 3GBK, 2ZK1, 5Z5S, 5DV3, 6MD0, 3LMP, 3V9T, 6IJS, 3VSP, 7E0A, 8DKN, 2Q6R, 6IZN, 7CXE, 4JL4, 6ONJ, 5LSG, 6DCU, 4XUH, 6T9C, 3KMG, 2PRG, 6AVI, 3BC5, 8B93, 6DGQ, 5GTP, 3B1M, 2HWQ, 8FKD, 5WR0, 2VV0, 1WM0, 6KTM, 9CK0, 8ZFN, 4L98, 3DZY, 6AN1, 5TTO, 3K8S, 6MD2, 6MCZ, 6C5Q, 1ZGY, 6F2L, 7CXH, 4PVU, 8ATZ, 8ZFQ, 2I4P, 2Q61, 6IJR, 8CPI, 1FM6, 6DGP, 4XTA, 6D3E, 6JEY, 3U9Q, 5Y2T, 3V9V, 8BF1, 3B3K, 2F4B, 8B8Z, 6DGR, 8B95, 3WJ5, 2HFP, 8FKC, 2HWR, 5WR1, 1KNU, 8FKE, 6FZP, 6KTN, 6FZF, 2ZK2, 7RLE, 5DV6, 3R5N, 5DV8, 9CWN, 8DSY, 3D6D, 4EM9, 6L89, 7CXK, 6QJ5, 2POB, 3ADU, 8ATY, 5U5L, 2Q5P, 6DHA, 8ZFP, 3FEJ, 3QT0, 1FM9, 4XUM, 4A4W, 8REJ, 2I4J, 3OSW, 6PDZ, 2VV2, 3CS8, 3VJI, 1NYX, 8B8W, 6T1S, 3ADV, 4PRG, 8FKF, 5HZC, 2VSR, 1K74, 6MD4, 6ICJ, 3SZ1, 7P4E, 3FUR, 8DSZ, 3ADW, 9F7X, 6T1V, 2ZK5, 8HUM, 6K0T, 6Y3U, 6O68, 7SQA, 2ZNO, 3B0Q, 8CPJ, 6C5T, 3VN2, 3PRG, 5DSH, 3DZU, 3X1H, 6DGO, 4A4V, 3CWD, 6VZM, 3VJH, 8AQM, 2G0H, 8SC9, 7EFQ, 8B8Y, 2ZK3, 6L8B, 7WOX, 2VV1, 3R8I, 7SQB, 4XLD, 8FHE, 4YT1, 4PWL, 6ZLY, 6MD1, 7JQG, 6DBH, 5Z6S, 3HO0, 2ZK4, 8HUP, 8C0C, 7CXI, 3G9E, 4JAZ, 8DK4, 6MS7, 3PBA, 8ZFO, 2YFE, 2QMV, 4FGY, 8BF2, 7WGQ, 5GTO, 5YCP, 3HOD, 5YCN, 6FZJ, 4CI5, 8B8X, 8B90, 2P4Y, 2VST, 1RDT, 8FKG, 8FHG, 8HHQ, 6VZO, 8CPH, 6ILQ, 6D94, 3NOA, 6TSG, 6E5A, 2ZK0, 3CDP, 3ADX, 9F7W, 6O67, 4R06, 2Q6S, 3X1I, 4F9M, 7AHJ, 6ENQ, 2XKW, 7CXG, 8ADF, 8U57, 3E00, 2I4Z, 6DH9, 8HHP, 8B94, 4EMA, 2OM9, 2G0G, 6T6B, 3V9Y, 2VV3, 3WMH, 6AUG, 3OSI, 6C1I, 4E4K, 8FHF, 6VZL, 8ZFT, 7LOT, 5JI0, 2ZK6, 4Y29, 5UGM, 4E4Q, 5WQX, 4R2U, 3S9S, 5TWO, 7A7H, 7QB1, 3ADS, 3H0A, 3ET3, 7CXF, 8PBO, 8ZFR, 3ET0, 8BFF, 3B0R

ZINC - Investigational

PPARG_HUMAN

ZINC - Metabolites

PPARG_HUMAN

HPA

ENSG00000132170-PPARG

GeneCards

PPARG

Pharos - Targets

P37231

Orphanet

PPARG

ZINC - Predictions - Purchasable

PPARG_HUMAN

HMDB Protein

HMDBP02173

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	16
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.64	3
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.632	5
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.592	2
UniProt:O60869 EDF1			0.581	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.576	5
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.571	2
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355)	0.556	3
UniProt:Q9BWX5 GATA5	1	GATA5 [nucleoplasm] (R-HSA-996731)	0.556	3
UniProt:Q8NFM4 ADCY4	1	ADCY4 [plasma membrane] (R-HSA-379054)	0.556	3
UniProt:Q6STE5-1 SMARCD3			0.544	3
UniProt:Q6STE5-2 SMARCD3			0.544	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.536	5
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.524	3
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.499	2
IntAct:EBI-6267604 SIR1			0.499	2

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