Reactome | monoSUMO1-K107,K395-PPARG [nucleoplasm]

monoSUMO1-K107,K395-PPARG [nucleoplasm]

Stable Identifier

R-HSA-4717444

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor gamma, PPARG_HUMAN

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External Reference Information

External Reference

UniProt:P37231 PPARG

Gene Names

PPARG, NR1C3

Chain

chain:1-505

Reference Genes

BioGPS Gene:5468 PPARG

COSMIC (genes):PPARG PPARG

CTD Gene:5468 PPARG

dbSNP Gene:5468 PPARG

ENSEMBL:ENSG00000132170 PPARG

ENSEMBL_homo_sapiens_GENE:ENSG00000132170.24 PPARG

HGNC:9236 PPARG

KEGG Gene (Homo sapiens):5468 PPARG

Monarch:5468 PPARG

NCBI Gene:5468 PPARG

OMIM:601487 PPARG

UCSC:P37231 PPARG

Reference Transcript

Other Identifiers

11720708_a_at

11753001_a_at

16937741

208510_PM_s_at

208510_s_at

2611079

2611080

2611081

2611086

2611087

2611089

2611090

2611094

2611101

2611111

2611112

2611113

37104_at

5468

8077899

A_14_P107054

A_14_P131601

A_23_P252062

A_33_P3350726

GE54254

GE60128

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001221

GO:0001227

GO:0001228

GO:0001890

GO:0002376

GO:0003012

GO:0003013

GO:0003676

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0004879

GO:0004955

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0006631

GO:0006919

GO:0006954

GO:0007005

GO:0007154

GO:0007165

GO:0007186

GO:0007584

GO:0008092

GO:0008217

GO:0008270

GO:0008289

GO:0009755

GO:0010628

GO:0010629

GO:0010742

GO:0010745

GO:0010875

GO:0010887

GO:0010888

GO:0010891

GO:0012501

GO:0015909

GO:0016071

GO:0016525

GO:0019899

GO:0023052

GO:0030154

GO:0030198

GO:0030224

GO:0030509

GO:0030512

GO:0030514

GO:0030855

GO:0032869

GO:0033993

GO:0035357

GO:0036211

GO:0042060

GO:0042277

GO:0042593

GO:0042752

GO:0042789

GO:0042802

GO:0042953

GO:0043226

GO:0043231

GO:0043235

GO:0043388

GO:0043407

GO:0043537

GO:0043565

GO:0043621

GO:0045087

GO:0045165

GO:0045600

GO:0045668

GO:0045892

GO:0045893

GO:0045923

GO:0045944

GO:0046872

GO:0046965

GO:0048384

GO:0048469

GO:0048511

GO:0048662

GO:0048856

GO:0048870

GO:0050544

GO:0050692

GO:0050693

GO:0050728

GO:0050872

GO:0050886

GO:0051091

GO:0051393

GO:0051716

GO:0055088

GO:0060089

GO:0060336

GO:0060392

GO:0060694

GO:0070165

GO:0070412

GO:0070888

GO:0071404

GO:0071456

GO:0090258

GO:0090575

GO:0097677

GO:0098542

GO:0140110

GO:0140297

GO:1900076

GO:1901202

GO:1902894

GO:1902895

GO:1903243

GO:1903845

GO:1904179

GO:1904597

GO:1904706

GO:1904893

GO:1905461

GO:1905563

GO:1905599

GO:2000272

HMNXSV003040514

ILMN_1687612

ILMN_1800225

ILMN_2364384

L40904_at

PH_hs_0024432

g7705548_3p_a_at

Participates

as an output of

PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)

Other forms of this molecule

PPARG [nucleoplasm]

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 107

Coordinate

107

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 395

Coordinate

395

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_011532143.1, NP_619725.2, NP_005028.4, NP_619726.2, NP_056953.2

ZINC - World Drugs

PPARG_HUMAN

Guide to Pharmacology - Targets

595

OpenTargets

ENSG00000132170

ZINC - FDA approved

PPARG_HUMAN

ZINC - Substances

PPARG_HUMAN

ZINC - Biogenic

PPARG_HUMAN

ZINC target

P37231

PRO

P37231

PDB

3U9Q, 7LOT, 4O8F, 5UGM, 3WMH, 8CPI, 3S9S, 7P4E, 3NOA, 2I4J, 2I4Z, 6ZLY, 6C5Q, 4CI5, 8AQN, 2G0G, 7E0A, 3ADX, 6JF0, 5Y2T, 6T1S, 3OSI, 5WR0, 2GTK, 5YCP, 8DK4, 6T6B, 5DV6, 2Q8S, 8CPH, 6DGO, 3FEJ, 6ONI, 2Q6R, 8DKV, 4A4V, 8AQM, 3GBK, 6VZO, 6KTM, 7AHJ, 6O67, 6QJ5, 7CXG, 2VST, 2ZNO, 3ADU, 8BF2, 5LSG, 6F2L, 5DV8, 5GTN, 8B95, 6JEY, 1ZGY, 8B8W, 3ET3, 3VSO, 8B8X, 5DSH, 8C0C, 3KMG, 1RDT, 2VV3, 2ZK1, 6AN1, 2PRG, 3R5N, 4E4Q, 7E2O, 6PDZ, 3PO9, 8BF1, 6KTN, 7AWD, 2Q6S, 3E00, 8B91, 2ZVT, 6FZP, 3ET0, 3WJ4, 1NYX, 6MD2, 8WFE, 7CXK, 6AVI, 6IJR, 2F4B, 2FVJ, 5DV3, 5TTO, 4XUH, 6AD9, 8HHP, 6FZG, 6TSG, 7EFQ, 4XUM, 6DGQ, 8B94, 2OM9, 6C1I, 3X1H, 2ZK4, 6DHA, 3PRG, 2XKW, 3CDP, 5WQX, 8HHQ, 5DWL, 6MS7, 6VZN, 7JQG, 3VJH, 4A4W, 4EM9, 7CXH, 7SQB, 3OSW, 7CXL, 7WGP, 3V9T, 1K74, 4JL4, 3H0A, 1KNU, 7QB1, 1FM9, 8B90, 2VSR, 4FGY, 3R8I, 3CWD, 8ATZ, 6K0T, 1I7I, 6L8B, 3V9Y, 6MD4, 4PRG, 4XLD, 5U5L, 6DCU, 3ADV, 6IZM, 5F9B, 4PVU, 4PWL, 6DH9, 3VJI, 8DSY, 8CPJ, 2ZK3, 6ENQ, 5HZC, 6JQ7, 3PBA, 4Y29, 4L98, 4XTA, 3D6D, 2HWQ, 2ZK2, 4E4K, 2I4P, 6D3E, 7CXE, 2Q59, 2ATH, 5AZV, 5GTO, 6VZM, 4OJ4, 6AUG, 3B0R, 7WGQ, 3QT0, 5YCN, 3B3K, 7SQA, 6ILQ, 6T1V, 5Z6S, 1WM0, 6E5A, 8HUP, 3ADS, 6IJS, 3X1I, 8ADF, 4JAZ, 5TWO, 2Q5S, 5GTP, 6L89, 3K8S, 7WOX, 6TDC, 8DSZ, 6Y3U, 4R2U, 3DZU, 3LMP, 2POB, 8B93, 2HWR, 2P4Y, 7CXI, 3G9E, 2G0H, 3AN3, 3ADW, 6IZN, 2VV2, 6D94, 6DBH, 6T9C, 4R6S, 2HFP, 6DGL, 2VV0, 1ZEO, 6FZJ, 3TY0, 4F9M, 6ICJ, 3R8A, 2ZK0, 8BFF, 7WGO, 7RLE, 2Q5P, 2VV4, 8B8Z, 4EMA, 8DKN, 3CS8, 6ONJ, 3VSP, 6FZY, 3VN2, 3CDS, 4R06, 3SZ1, 8HUM, 2Q61, 6C5T, 6MD0, 3IA6, 5JI0, 6VZL, 5Y2O, 1PRG, 8B8Y, 6O68, 5Z5S, 2QMV, 7CXF, 5DVC, 6FZF, 7CXJ, 3WJ5, 3HOD, 3T03, 6D8X, 4HEE, 3B0Q, 3DZY, 4L96, 3V9V, 3B1M, 3BC5, 8ATY, 1FM6, 6MD1, 3AN4, 4YT1, 2ZK6, 3FUR, 3HO0, 2YFE, 6DGP, 8B92, 2VV1, 7A7H, 6DGR, 3ADT, 7AWC, 6MCZ, 2ZK5, 5WR1

ZINC - Investigational

PPARG_HUMAN

ZINC - Metabolites

PPARG_HUMAN

HPA

ENSG00000132170-PPARG

GeneCards

P37231

Ensembl

ENST00000287820, ENSP00000287820, ENSG00000132170

Pharos - Targets

P37231

ZINC - Predictions - Purchasable

PPARG_HUMAN

Orphanet

15129

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	16
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.64	3
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.632	5
UniProt:Q9UBK2 PPARGC1A	4	monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) PPARGC1A [nucleoplasm] (R-HSA-442481)	0.592	2
UniProt:O60869 EDF1			0.581	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.576	5
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.571	2
UniProt:Q8NFM4 ADCY4	1	ADCY4 [plasma membrane] (R-HSA-379054)	0.556	3
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.556	3
UniProt:Q9BWX5 GATA5	1	GATA5 [nucleoplasm] (R-HSA-996731)	0.556	3
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q6STE5-2 SMARCD3			0.544	3
UniProt:Q6STE5-1 SMARCD3			0.544	3
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.524	3
IntAct:EBI-6267604 SIR1			0.499	2
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.499	2