PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene

Stable Identifier
R-HSA-400204
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene
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Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type II nuclear receptor (its subcellular location is independent of ligand binding) related to PPAR-beta/delta and PPAR-gamma. PPAR-alpha is expressed highly in the liver where if functions to control lipid metabolism, especially fatty acid oxidation.
PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha). The heterodimers bind peroxisome proliferator receptor elements (PPREs) in and around genes regulated by PPAR-alpha.

Literature References
PubMed ID Title Journal Year
16476485 From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

Feige, JN, Gelman, L, Michalik, L, Desvergne, B, Wahli, W

Prog Lipid Res 2006
16503871 Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis

Gouni-Berthold, I, Krone, W

Curr Drug Targets Cardiovasc Haematol Disord 2005
8386511 PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene

Bardot, O, Aldridge, TC, Latruffe, N, Green, S

Biochem Biophys Res Commun 1993
10529898 Peroxisome proliferator-activated receptors: nuclear control of metabolism

Desvergne, B, Wahli, W

Endocr Rev 1999
11330046 Peroxisome proliferator-activated receptors, coactivators, and downstream targets

Qi, C, Zhu, Y, Reddy, JK

Cell Biochem Biophys 2000
18288277 Peroxisome proliferator activated receptors and lipoprotein metabolism

Kersten, S

PPAR Res 2008
Participants
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Orthologous Events
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Authored
May, B  (2009-05-30)
Reviewed
Kersten, S  (2009-06-08)
Created
May, B  (2009-03-24)