PPARA binds RXRA

Stable Identifier
R-HSA-400204
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene
ReviewStatus
5/5
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PPARA binds RXRA
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Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type II nuclear receptor (its subcellular location is independent of ligand binding) related to PPAR-beta/delta and PPAR-gamma. PPAR-alpha is expressed highly in the liver where if functions to control lipid metabolism, especially fatty acid oxidation.
PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha). The heterodimers bind peroxisome proliferator receptor elements (PPREs) in and around genes regulated by PPAR-alpha.
Literature References
PubMed ID Title Journal Year
16503871 Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis

Gouni-Berthold, I, Krone, W

Curr Drug Targets Cardiovasc Haematol Disord 2005
16476485 From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

Feige, JN, Gelman, L, Michalik, L, Desvergne, B, Wahli, W

Prog Lipid Res 2006
8386511 PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene

Bardot, O, Aldridge, TC, Latruffe, N, Green, S

Biochem Biophys Res Commun 1993
10529898 Peroxisome proliferator-activated receptors: nuclear control of metabolism

Desvergne, B, Wahli, W

Endocr Rev 1999
11330046 Peroxisome proliferator-activated receptors, coactivators, and downstream targets

Qi, C, Zhu, Y, Reddy, JK

Cell Biochem Biophys 2000
18288277 Peroxisome proliferator activated receptors and lipoprotein metabolism

Kersten, S

PPAR Res 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

RNA polymerase II cis-regulatory region sequence-specific DNA binding activity of RXRA [nucleoplasm]

Physical Entity
RXRA [nucleoplasm] (Homo sapiens)
Activity
RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)
Orthologous Events
PPARA binds RXRA (Bos taurus)
PPARA binds RXRA (Canis familiaris)
PPARA binds RXRA (Danio rerio)
PPARA binds RXRA (Drosophila melanogaster)
PPARA binds RXRA (Gallus gallus)
PPARA binds RXRA (Mus musculus)
PPARA binds RXRA (Rattus norvegicus)
PPARA binds RXRA (Sus scrofa)
Authored
May, B  (2009-05-30)
Reviewed
Kersten, S  (2009-06-08)
Hill, DP  (2025-06-16)
Hill, DP  (2025-08-13)
Created
May, B  (2009-03-24)
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