Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type II nuclear receptor (its subcellular location is independent of ligand binding) related to PPAR-beta/delta and PPAR-gamma. PPAR-alpha is expressed highly in the liver where if functions to control lipid metabolism, especially fatty acid oxidation. PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha). The heterodimers bind peroxisome proliferator receptor elements (PPREs) in and around genes regulated by PPAR-alpha.
Gouni-Berthold, I, Krone, W
Gelman, L, Wahli, W, Michalik, L, Desvergne, B, Feige, JN
Green, S, Bardot, O, Aldridge, TC, Latruffe, N
Wahli, W, Desvergne, B
Qi, C, Reddy, JK, Zhu, Y
Kersten, S
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