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TXNIP [cytosol]
Stable Identifier
R-HSA-1250246
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Thioredoxin-interacting protein, TXNIP_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP binds reduced thioredoxin (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
Thioredoxin:TXNIP [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
Oxidized thioredoxin:TXNIP [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP binds reduced thioredoxin (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
Thioredoxin:TXNIP [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
Oxidized thioredoxin:TXNIP [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
TXNIP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H3M7 TXNIP
Gene Names
TXNIP, VDUP1
Chain
chain:1-391
Reference Genes
BioGPS Gene:10628 TXNIP
COSMIC (genes):TXNIP TXNIP
CTD Gene:10628 TXNIP
dbSNP Gene:10628 TXNIP
ENSEMBL:ENSG00000265972 TXNIP
HGNC:16952 TXNIP
KEGG Gene (Homo sapiens):10628 TXNIP
Monarch:10628 TXNIP
NCBI Gene:10628 TXNIP
OMIM:606599 TXNIP
UCSC:Q9H3M7 TXNIP
Reference Transcript
RefSeq:NM_001313972.1 TXNIP
RefSeq:NM_006472.5 TXNIP
Other Identifiers
0001740092
10628
11717190_s_at
11748543_a_at
11748544_s_at
11752765_s_at
11756431_s_at
16669796
201008_s_at
201009_s_at
201010_s_at
2356116
2356117
2356118
2356120
2356121
2356123
2356125
2356127
2356128
2356130
2356132
2356134
2356135
2356136
2356137
2356138
31508_at
64281_s_at
7904726
A_23_P97700
GE58805
GO:0000122
GO:0003674
GO:0004857
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005758
GO:0005829
GO:0006606
GO:0006810
GO:0006913
GO:0006950
GO:0006979
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0009612
GO:0009749
GO:0015031
GO:0019899
GO:0030154
GO:0030216
GO:0030234
GO:0031625
GO:0032355
GO:0032570
GO:0034641
GO:0035590
GO:0042127
GO:0042493
GO:0042542
GO:0043065
GO:0043086
GO:0043226
GO:0048008
GO:0048856
GO:0051301
GO:0051592
GO:0051782
GO:0071228
HMNXSV003003998
Hs.179526.0.S1_3p_a_at
Hs.179526.0.S2_3p_a_at
ILMN_1697448
PH_hs_0010634
S73591_at
TC01001090.hg
g5454161_3p_a_at
Participates
as an output of
TXNIP is released from oxidized thioredoxin (Homo sapiens)
as a component of
Oxidized thioredoxin:TXNIP [cytosol] (Homo sapiens)
Thioredoxin:TXNIP [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
as an input of
TXNIP binds reduced thioredoxin (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
Other forms of this molecule
TXNIP [nucleoplasm]
Inferred To
txnipa [cytosol]
(Danio rerio)
adcA [cytosol]
(Dictyostelium discoideum)
Txnip [cytosol]
(Mus musculus)
Txnip [cytosol]
(Rattus norvegicus)
adcB [cytosol]
(Dictyostelium discoideum)
Homologues of TXNIP [cytosol]
(Dictyostelium discoideum)
Homologues of TXNIP [cytosol]
(Schizosaccharomyces pombe)
adcC [cytosol]
(Dictyostelium discoideum)
TXNIP [cytosol]
(Canis familiaris)
TXNIP [cytosol]
(Gallus gallus)
TXNIP [cytosol]
(Schizosaccharomyces pombe)
TXNIP [cytosol]
(Sus scrofa)
adcF [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001300901.1
,
NP_006463.3
OpenTargets
ENSG00000265972
GeneCards
Q9H3M7
HPA
ENSG00000265972-TXNIP
Ensembl
ENSG00000265972
,
ENSP00000462521
,
ENSP00000396322
,
ENST00000582401
,
ENST00000425134
PRO
Q9H3M7
Pharos - Targets
Q9H3M7
GlyGen
Q9H3M7
PDB
4GEI
,
4LL4
,
5DZD
,
4ROJ
,
4LL1
,
5DWS
,
5DF6
,
4ROF
,
4GFX
,
4GEJ
,
5CQ2
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.743
8
UniProt:O95905 ECD
0.591
5
UniProt:P52735 VAV2
2
VAV2 [cytosol]
(R-HSA-195012)
p-Y172-VAV2 [cytosol]
(R-HSA-442307)
0.558
2
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