Reactome | Gatad2b [nucleoplasm]

Gatad2b [nucleoplasm]

Stable Identifier

R-MMU-3702079

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

GATAD2B, Q8VHR5

Locations in the PathwayBrowser

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Chromatin organization (Mus musculus)

- Chromatin modifying enzymes (Mus musculus)
  - HDACs deacetylate histones (Mus musculus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)
    - HDAC1:2-containing complex deacetylate histones (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase I Transcription (Mus musculus)
  - RNA Polymerase I Promoter Clearance (Mus musculus)
    - RNA Polymerase I Transcription Initiation (Mus musculus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Acetylation (Mus musculus)
        
        MTA2-NuRD complex deacetylates TP53 (Mus musculus)
        
        MTA2-NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        SALL4 recruits NuRD to PTEN gene (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)
        
        Gatad2b [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8VHR5 Gatad2b

Gene Names

Gatad2b

Chain

chain:1-594

Reference Genes

BioGPS Gene:229542 Gatad2b

ENSEMBL:ENSMUSG00000042390.10 Gatad2b

KEGG Gene (Mus musculus):229542 Gatad2b

Monarch:229542 Gatad2b

NCBI Gene:229542 Gatad2b

UCSC:Q8VHR5 Gatad2b

Reference Transcript

Other Identifiers

10493758

1425075_at

1437474_at

1437507_at

17399737

229542

4386495

4401122

4427234

4583713

4614193

4787245

4815348

4907501

4915301

4982654

5083731

5113609

5137369

5302920

5392441

5515965

5529449

A_52_P494115

A_52_P582601

A_55_P2735230

GE42189

GO:0000122

GO:0000781

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008270

GO:0016581

GO:0016607

GO:0030154

GO:0042659

GO:0043226

GO:0043565

GO:0045892

GO:0045893

GO:0046872

GO:2000736

ILMN_1251852

ILMN_2468451

mMC014539

mMR029794

Participates

as a candidate of

(GATAD2A, GATAD2B) [nucleoplasm] (Mus musculus)

Other forms of this molecule

Gatad2b [nucleoplasm]

Inferred From

GATAD2B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006501422.2, NP_647465.1, XP_006501424.1

Ensembl

ENSMUSP00000142514, ENSMUST00000049382, ENSMUSG00000042390, ENSMUST00000199607, ENSMUSP00000041370, ENSMUST00000199754, ENSMUSP00000142617

PRO

Q8VHR5

MGI

2443225

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12813	2	phospho-Nr4a1 [nucleoplasm] (R-MMU-199846) Nr4a1 [nucleoplasm] (R-MMU-199831)	0.499	2