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KLHL12 [cytosol]
Stable Identifier
R-HSA-1504203
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of DVL (Homo sapiens)
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
KLHL12 [cytosol] (Homo sapiens)
DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
KLHL12 [cytosol] (Homo sapiens)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Homo sapiens)
DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
KLHL12 [cytosol] (Homo sapiens)
ub-DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
KLHL12 [cytosol] (Homo sapiens)
Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
KLHL12 [cytosol] (Homo sapiens)
ub-DVL:CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
KLHL12 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q53G59 KLHL12
Gene Names
KLHL12, C3IP1
Chain
chain:1-568
Reference Genes
BioGPS Gene:59349 KLHL12
COSMIC (genes):KLHL12 KLHL12
CTD Gene:59349 KLHL12
dbSNP Gene:59349 KLHL12
ENSEMBL:ENSG00000117153 KLHL12
HGNC:19360 KLHL12
KEGG:hsa:59349 KLHL12
Monarch:59349 KLHL12
NCBI Gene:59349 KLHL12
OMIM:614522 KLHL12
UCSC:Q53G59 KLHL12
Reference Transcript
RefSeq:NM_021633.3 KLHL12
RefSeq:NM_001303109.1 KLHL12
RefSeq:NM_001303051.1 KLHL12
Other Identifiers
11717663_a_at
11717664_s_at
16698101
219931_3p_s_at
219931_PM_s_at
219931_s_at
225068_PM_at
225068_at
2451429
2451430
2451431
2451432
2451433
2451434
2451435
2451436
2451437
2451440
2451441
2451442
2451443
2451446
2451453
2451455
2451456
2451457
2451458
2451459
2451460
2451462
3937571
3937573
3937576
3937579
3937581
59349
65869_at
7923489
A_23_P161041
A_24_P242609
A_33_P3394021
GE62068
GO:0005515
GO:0005829
GO:0006513
GO:0006888
GO:0014029
GO:0014032
GO:0016055
GO:0016192
GO:0016567
GO:0030127
GO:0030134
GO:0030154
GO:0031410
GO:0031463
GO:0034451
GO:0042802
GO:0043226
GO:0043231
GO:0048208
GO:0048856
GO:0065003
HMNXSV003018657
HMNXSV003022245
Hs.3826.1.A2_3p_at
ILMN_1676075
ILMN_2164081
PH_hs_0000431
TC01003709.hg
g11056005_3p_a_at
g11056005_3p_s_at
Participates
as a component of
CUL3:KLHL12:RBX1 [cytosol] (Homo sapiens)
Inferred To
KLHL12 [cytosol]
(Bos taurus)
KLHL12 [cytosol]
(Dictyostelium discoideum)
KLHL12 [cytosol]
(Gallus gallus)
Ghost homologue of KLHL12 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of KLHL12 [cytosol]
(Canis familiaris)
Ghost homologue of KLHL12 [cytosol]
(Drosophila melanogaster)
Ghost homologue of KLHL12 [cytosol]
(Xenopus tropicalis)
RABIF [cytosol]
(Sus scrofa)
Klhl12 [cytosol]
(Mus musculus)
Klhl12 [cytosol]
(Rattus norvegicus)
klhl12 [cytosol]
(Danio rerio)
Cross References
ENSEMBL
ENSP00000356230
,
ENSG00000117153
,
ENST00000367261
OpenTargets
ENSG00000117153
GeneCards
KLHL12
HPA
ENSG00000117153-KLHL12
PRO
Q53G59
Pharos - Targets
Q53G59
PDB
6TTK
,
6V7O
,
2VPJ
,
8OIO
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.795
8
UniProt:Q6IQ55 TTBK2
1
TTBK2 [cytosol]
(R-HSA-5626168)
0.718
6
UniProt:O95050 INMT
1
INMT [cytosol]
(R-HSA-5357693)
0.718
6
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.558
11
UniProt:Q71SY5 MED25
1
MED25 [nucleoplasm]
(R-HSA-212414)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P41182 BCL6
1
BCL6 [nucleoplasm]
(R-HSA-5223066)
0.556
3
UniProt:Q8IVS8 GLYCTK
1
GLYCTK [cytosol]
(R-HSA-6799244)
0.556
3
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.556
3
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.488
2
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