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MVK [cytosol]
Stable Identifier
R-HSA-191375
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Mevalonate kinase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Homo sapiens)
MVK dimer [cytosol] (Homo sapiens)
MVK [cytosol] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Mevalonate Kinase (MVK) (Homo sapiens)
MVK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03426 MVK
Gene Names
MVK
Chain
chain:1-396
Reference Genes
BioGPS Gene:4598 MVK
COSMIC (genes):MVK MVK
CTD Gene:4598 MVK
dbSNP Gene:4598 MVK
ENSEMBL:ENSG00000110921 MVK
HGNC:7530 MVK
KEGG:hsa:4598 MVK
Monarch:4598 MVK
NCBI Gene:4598 MVK
OMIM:251170 MVK
UCSC:Q03426 MVK
Reference Transcript
RefSeq:NM_000431.3 MVK
RefSeq:XM_017019314.1 MVK
RefSeq:NM_001301182.1 MVK
RefSeq:NM_001114185.2 MVK
Other Identifiers
11719098_a_at
11747747_a_at
16756804
204056_PM_s_at
204056_s_at
215649_PM_s_at
215649_s_at
236686_PM_at
236686_at
3431221
3431222
3431223
3431224
3431225
3431227
3431229
3431230
3431232
3431233
3431234
3431235
3431236
3431237
3431238
3431239
3431240
3431241
3431242
3431243
3431244
36907_3p_at
36907_PM_at
36907_at
4598
4874933C_3p_s_at
59750_at
59893_at
7958565
A_14_P115327
A_23_P105592
A_24_P372901
GE60000
GO:0000287
GO:0003824
GO:0004496
GO:0005515
GO:0005524
GO:0005737
GO:0005777
GO:0005829
GO:0006629
GO:0006695
GO:0006790
GO:0008299
GO:0016301
GO:0016740
GO:0016773
GO:0019287
GO:0042802
GO:0043226
GO:0043231
GO:0046872
GO:0050728
GO:0055086
GO:1901135
HMNXSV003043579
Hs.288391.0.A1_3p_at
Hs.306585.0.S1_3p_s_at
ILMN_1786310
M88468_at
PH_hs_0027241
TC12000849.hg
g4557768_3p_a_at
Participates
as an output of
Expression of Mevalonate Kinase (MVK) (Homo sapiens)
as a component of
MVK dimer [cytosol] (Homo sapiens)
Inferred To
Mvk [cytosol]
(Drosophila melanogaster)
mvk [cytosol]
(Danio rerio)
MVK [cytosol]
(Bos taurus)
MVK [cytosol]
(Canis familiaris)
MVK [cytosol]
(Dictyostelium discoideum)
MVK [cytosol]
(Gallus gallus)
MVK [cytosol]
(Mus musculus)
MVK [cytosol]
(Rattus norvegicus)
MVK [cytosol]
(Saccharomyces cerevisiae)
MVK [cytosol]
(Schizosaccharomyces pombe)
MVK [cytosol]
(Sus scrofa)
mvk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
640
ENSEMBL
ENST00000228510
,
ENSP00000228510
,
ENSP00000438153
,
ENST00000546277
,
ENSG00000110921
OpenTargets
ENSG00000110921
GeneCards
MVK
HPA
ENSG00000110921-MVK
PRO
Q03426
Pharos - Targets
Q03426
Orphanet
MVK
HMDB Protein
HMDBP01053
PDB
2R3V
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03426 MVK
1
MVK [cytosol]
(R-HSA-191375)
0.881
12
UniProt:Q8WVD5 RN141
0.556
3
UniProt:Q01844 EWS
0.553
2
UniProt:Q9Y6A5 TACC3
1
TACC3 [cytosol]
(R-HSA-2160956)
0.527
2
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.527
2
UniProt:Q6JEL2 KLH10
0.527
3
UniProt:P36269 GGT5
2
GGT5(1-387) [plasma membrane]
(R-HSA-265313)
GGT5(388-586) [plasma membrane]
(R-HSA-265312)
0.527
2
UniProt:Q8TDM5 SPACA4
2
cleaved GPI-SPACA4 [extracellular region]
(R-HSA-8941103)
GPI-SPACA4 [plasma membrane]
(R-HSA-8940689)
0.527
2
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.508
2
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