Reactome | EED [nucleoplasm]

EED [nucleoplasm]

Stable Identifier

R-HSA-212278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75530 EED

Gene Names

EED

Chain

initiator methionine:1, chain:2-441

Reference Genes

BioGPS Gene:8726 EED

COSMIC (genes):EED EED

CTD Gene:8726 EED

dbSNP Gene:8726 EED

ENSEMBL:ENSG00000074266.22 EED

HGNC:3188 EED

KEGG Gene (Homo sapiens):8726 EED

Monarch:8726 EED

NCBI Gene:8726 EED

OMIM:605984 EED

UCSC:O75530 EED

Reference Transcript

Other Identifiers

11728378_a_at

11750166_a_at

11753489_a_at

16729712

209572_PM_s_at

209572_s_at

210656_PM_at

210656_at

31853_at

3343203

3343204

3343205

3343206

3343208

3343209

3343210

3343211

3343212

3343216

3343217

3343219

3343220

3343224

3343226

3343227

3343228

3343229

3343230

7942914

8726

A_14_P133848

A_14_P138443

A_23_P53217

GE81323

GO:0000122

GO:0001222

GO:0003682

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006351

GO:0006355

GO:0008047

GO:0016570

GO:0016571

GO:0016740

GO:0021510

GO:0031491

GO:0035098

GO:0036211

GO:0042054

GO:0042802

GO:0043226

GO:0045892

GO:0048856

GO:0098772

GO:0140096

HMNXSV003036020

HMNXSV003039068

HMNXSV003042355

ILMN_1710150

ILMN_1796813

ILMN_2347917

PH_hs_0026886

TC11000870.hg

U90651_at

g3420789_3p_a_at

Participates

as an output of

E2F1/2/3 stimulates EED transcription (Homo sapiens)

as an input of

Formation of PRC2-EZH2 complex (Homo sapiens)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)

Inferred To

EED [nucleoplasm] (Bos taurus)

EED [nucleoplasm] (Canis familiaris)

EED [nucleoplasm] (Gallus gallus)

EED [nucleoplasm] (Sus scrofa)

escl [nucleoplasm] (Drosophila melanogaster)

Eed [nucleoplasm] (Mus musculus)

Eed [nucleoplasm] (Rattus norvegicus)

eed [nucleoplasm] (Danio rerio)

eed [nucleoplasm] (Xenopus tropicalis)

mes-6 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001294936.1, NP_003788.2

Guide to Pharmacology - Targets

2487

OpenTargets

ENSG00000074266

HPA

ENSG00000074266-EED

GeneCards

O75530

Ensembl

ENSP00000338186, ENSG00000074266, ENST00000263360, ENSP00000500834, ENST00000672825, ENST00000351625, ENSP00000263360, ENST00000327320, ENSP00000315587

ZINC target

O75530

PRO

O75530

Pharos - Targets

O75530

PDB

6SFC, 5U8F, 7P3J, 3JZN, 6SFB, 4X3E, 7QJG, 5U5H, 6U4Y, 5GSA, 3JZH, 3JZG, 5U8A, 6C24, 5U69, 7TD5, 5H17, 5H15, 6V3X, 5U62, 7P3C, 7SI4, 5U5T, 3IIY, 3IJ1, 3IJ0, 7P3G, 7SI5, 5IJ7, 5IJ8, 5TTW, 5U5K, 7MSD, 3JPX, 5LS6, 6LO2, 5U6D, 5H19, 6YVI, 5HYN, 4W2R, 7KTP, 5WP3, 3IJC, 7KXT, 6V3Y, 7QJU, 7QK4, 3K27, 6W7G, 6C23, 6B3W, 5WUK, 6YVJ, 5H25, 6WKR, 7KSO, 6W7F, 5H14, 3K26, 7KSR, 5H13, 5H24, 3IIW, 5K0M, 7MSB, 5WG6

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.914	15
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.899	10
UniProt:Q9UBC3 DNMT3B	2	SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334) DNMT3B [nucleoplasm] (R-HSA-212316)	0.662	4
UniProt:Q92800 EZH1			0.659	4
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.643	4
UniProt:Q9Y483 MTF2	1	MTF2 [nucleoplasm] (R-HSA-5084119)	0.643	4
UniProt:Q92833 JARID2	1	JARID2 [nucleoplasm] (R-HSA-2160949)	0.643	4
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.643	4
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.623	3
IntAct:EBI-15887193 H3K27-1			0.618	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.564	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.564	4
IntAct:EBI-15643864 H3K9-1			0.558	5
IntAct:EBI-15887143 H3K79			0.558	2
IntAct:EBI-15887169 H1K26			0.558	2
IntAct:EBI-15697673 H4K20AC			0.558	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.558	7
UniProt:Q6ZN18 AEBP2	1	AEBP2 [nucleoplasm] (R-HSA-5082342)	0.528	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.527	3
UniProt:Q96JN0 LCOR			0.527	4
UniProt:Q9JJY3	1	SMPD3 [plasma membrane] (R-MMU-1606265)	0.527	5
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.527	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	3
UniProt:A6NHQ4 EPOP			0.527	3
UniProt:Q6ZN18-2 AEBP2			0.527	2
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	3
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.525	2
UniProt:Q9Y6K1 DNMT3A	2	monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415) DNMT3A [nucleoplasm] (R-HSA-212287)	0.499	2
UniProt:Q15156 Q15156			0.499	2
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.499	5
UniProt:Q92833-1 JARID2			0.499	4

Cite Us!