PRC2 (EZH2) Core [nucleoplasm]

Stable Identifier
Homo sapiens
Polycomb Repressive Complex 2 (PRC2) Core, SUZ12:EED:EZH2:RpAp46,48
Locations in the PathwayBrowser

The human Polycomb Repressive Complex 2 (PRC2) is homologous to the Drosophila PRC2. The core PRC2 contains EZH2, a histone methyltransferase specific for lysine 27 and lysine 9 of histone H3. The methyltransferase activity of EZH2 is dependent on its association with PRC2. The complex contains other uncharacterized proteins, its composition may vary in different tissues and developmental stages, and the order of assembly of the complex is presently unknown.

Literature References
PubMed ID Title Journal Year
15225548 SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

Zhang, Y, Cao, R

Mol. Cell 2004
12435631 Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Nishioka, K, Reinberg, D, Kuzmichev, A, Tempst, P, Erdjument-Bromage, H

Genes Dev 2002
23110252 Molecular architecture of human polycomb repressive complex 2

Aebersold, R, Nogales, E, Lander, GC, Ciferri, C, Herzog, F, Maiolica, A

Elife 2012
12351676 Role of histone H3 lysine 27 methylation in Polycomb-group silencing

Jones, RS, Zhang, Y, Cao, R, Xia, L, Tempst, P, Wang, L, Wang, H, Erdjument-Bromage, H

Science 2002
15099518 Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3

Reinberg, D, Kuzmichev, A, Jenuwein, T, Tempst, P

Mol Cell 2004
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