PRC2 (EZH2) Core

Stable Identifier
R-HSA-212285
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
Polycomb Repressive Complex 2 (PRC2) Core, SUZ12:EED:EZH2:RpAp46,48
Locations in the PathwayBrowser
Summation

The human Polycomb Repressive Complex 2 (PRC2) is homologous to the Drosophila PRC2. The core PRC2 contains EZH2, a histone methyltransferase specific for lysine 27 and lysine 9 of histone H3. The methyltransferase activity of EZH2 is dependent on its association with PRC2. The complex contains other uncharacterized proteins, its composition may vary in different tissues and developmental stages, and the order of assembly of the complex is presently unknown.

Literature References
PubMed ID Title Journal Year
12435631 Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Kuzmichev, A, Nishioka, K, Erdjument-Bromage, H, Tempst, P, Reinberg, D

Genes Dev 2002
15225548 SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

Cao, R, Zhang, Y

Mol. Cell 2004
23110252 Molecular architecture of human polycomb repressive complex 2

Ciferri, C, Lander, GC, Maiolica, A, Herzog, F, Aebersold, R, Nogales, E

Elife 2012
12351676 Role of histone H3 lysine 27 methylation in Polycomb-group silencing

Cao, R, Wang, L, Wang, H, Xia, L, Erdjument-Bromage, H, Tempst, P, Jones, RS, Zhang, Y

Science 2002
15099518 Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3

Kuzmichev, A, Jenuwein, T, Tempst, P, Reinberg, D

Mol Cell 2004
Participants
Participant Of
hasMember
Inferred To