Reactome | SUMO1-K-DNMT3B [nucleoplasm]

SUMO1-K-DNMT3B [nucleoplasm]

Stable Identifier

R-HSA-4655334

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA, DNM3B_HUMAN

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External Reference Information

External Reference

UniProt:Q9UBC3 DNMT3B

Gene Names

DNMT3B

Chain

chain:1-853

Reference Genes

BioGPS Gene:1789 DNMT3B

COSMIC (genes):DNMT3B DNMT3B

CTD Gene:1789 DNMT3B

dbSNP Gene:1789 DNMT3B

ENSEMBL:ENSG00000088305 DNMT3B

ENSEMBL_homo_sapiens_GENE:ENSG00000088305.19 DNMT3B

HGNC:2979 DNMT3B

KEGG Gene (Homo sapiens):1789 DNMT3B

Monarch:1789 DNMT3B

NCBI Gene:1789 DNMT3B

OMIM:602900 DNMT3B

UCSC:Q9UBC3 DNMT3B

Reference Transcript

Other Identifiers

11727987_a_at

11736975_a_at

11738806_a_at

11742036_a_at

11750122_a_at

11751190_x_at

11751942_a_at

11752657_a_at

11752658_x_at

16912597

1789

220668_PM_s_at

220668_s_at

3882015

3882016

3882017

3882018

3882024

3882025

3882027

3882029

3882030

3882031

3882032

3882033

3882035

3882036

3882037

3882039

3882040

3882042

3882045

3882046

3882047

3882051

3882052

3882053

3882056

3882057

3882059

3882060

3882062

3882064

3882065

3882066

47584_at

8061746

A_14_P103258

A_14_P138075

A_23_P28953

GE62941

GO:0000122

GO:0003677

GO:0003714

GO:0003824

GO:0003886

GO:0005515

GO:0005634

GO:0005654

GO:0006306

GO:0006351

GO:0006355

GO:0008168

GO:0009008

GO:0010468

GO:0010605

GO:0010628

GO:0016740

GO:0032259

GO:0032776

GO:0043226

GO:0046872

GO:0051718

GO:0090116

GO:0140097

GO:0140110

GO:1902494

HMNXSV003041005

ILMN_1733929

ILMN_1734285

ILMN_1794692

ILMN_2328972

ILMN_2328977

PH_hs_0013311

TC20000215.hg

TC20001194.hg

g5901939_3p_a_at

Participates

as an output of

SUMOylation of DNMT3B with SUMO1 (Homo sapiens)

Other forms of this molecule

DNMT3B [nucleoplasm]

Inferred To

SUMO1-K-DNMT3B [nucleoplasm] (Gallus gallus)

SUMO1-K-DNMT3B [nucleoplasm] (Mus musculus)

DNMT3B [nucleoplasm] (Bos taurus)

DNMT3B [nucleoplasm] (Sus scrofa)

Dnmt3b [nucleoplasm] (Rattus norvegicus)

dnmt3bb.1 [nucleoplasm] (Danio rerio)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_787046.1, NP_787044.1, NP_008823.1, NP_001193984.1, NP_787045.1, NP_001193985.1

ZINC - World Drugs

DNM3B_HUMAN

OpenTargets

ENSG00000088305

ZINC - Substances

DNM3B_HUMAN

ZINC target

Q9UBC3

ZINC - Biogenic

DNM3B_HUMAN

PRO

Q9UBC3

PDB

6KDA, 6U8P, 6KDB, 5NV2, 5NV0, 8EIK, 8EIJ, 5NRR, 6PA7, 7V0E, 5NV7, 5NVO, 6U8X, 8EII, 6KDP, 3QKJ, 5NRV, 6KDT, 5NRS, 3FLG, 6U8V, 5NR3, 6U90, 6KDL, 6U91, 6R3E, 5CIU, 8EIH, 7O45, 6U8W, 7X9D

ZINC - Metabolites

DNM3B_HUMAN

IntEnz

2.1.1.37

HPA

ENSG00000088305-DNMT3B

GeneCards

Q9UBC3

Ensembl

ENSG00000088305, ENSP00000412305, ENSP00000313397, ENSP00000328547, ENST00000456297, ENST00000348286, ENSP00000337764, ENSP00000201963, ENST00000201963, ENST00000443239, ENST00000328111, ENST00000353855, ENSP00000403169

Pharos - Targets

Q9UBC3

ZINC - Predictions - Purchasable

DNM3B_HUMAN

Orphanet

15883

HMDB Protein

HMDBP02251

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.834	14
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.662	4
UniProt:Q9Y6K1 DNMT3A	2	monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415) DNMT3A [nucleoplasm] (R-HSA-212287)	0.635	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.597	4
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.597	5
UniProt:Q96T88 UHRF1	2	UHRF1 [cytosol] (R-HSA-9818452) UHRF1 [nucleoplasm] (R-HSA-212103)	0.591	7
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.59	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.567	3
UniProt:Q9QR71 LANA1			0.544	2
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.462	2
IntAct:EBI-1265559 MYC			0.462	2
IntAct:EBI-5276484 ACTB			0.462	2
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.462	3

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