Reactome | Eed [nucleoplasm]

Eed [nucleoplasm]

Stable Identifier

R-MMU-212278

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

EED, Q921E6

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Mus musculus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
        
        Eed [nucleoplasm] (Mus musculus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Mus musculus)
        
        PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)
        
        Eed [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q921E6 Eed

Gene Names

Eed

Chain

initiator methionine:1, chain:2-441

Reference Genes

BioGPS Gene:13626 Eed

ENSEMBL:ENSMUSG00000030619 Eed

KEGG Gene (Mus musculus):13626 Eed

Monarch:13626 Eed

NCBI Gene:13626 Eed

UCSC:Q921E6 Eed

Reference Transcript

RefSeq:NM_021876.3 Eed

Other Identifiers

103342_at

10565486

13626

1448653_at

17493250

4473100

4595014

4667683

4759763

4949761

4974637

4980148

4985382

5005382

5075784

5117265

5304590

5345664

5370607

5394843

5469124

5489702

5546116

A_51_P238643

A_55_P2039611

GE38087

GO:0000122

GO:0000978

GO:0001222

GO:0001739

GO:0003677

GO:0003682

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005677

GO:0005694

GO:0005737

GO:0005829

GO:0006325

GO:0006349

GO:0006351

GO:0006355

GO:0008047

GO:0016571

GO:0016740

GO:0030154

GO:0031491

GO:0032991

GO:0035098

GO:0036211

GO:0042054

GO:0042802

GO:0043226

GO:0045120

GO:0048709

GO:0048856

GO:0050790

GO:0061087

GO:0098772

GO:0140096

GO:0140718

GO:1990830

GO:2000011

ILMN_2765015

mMC012396

u78103_s_at

Participates

as an input of

Formation of PRC2-EZH2 complex (Mus musculus)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Mus musculus)

Other forms of this molecule

Eed [nucleoplasm]

Inferred From

EED [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_068676.1

Ensembl

ENSMUSG00000030619, ENSMUST00000107234, ENSMUSP00000159149, ENSMUSP00000102853, ENSMUST00000238981

PRO

Q921E6

MGI

95286

PDB

2QXV

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q61188 Ezh2	1	Ezh2 [nucleoplasm] (R-MMU-5617899)	0.858	10
UniProt:Q62315	1	Jarid2 [nucleoplasm] (R-MMU-2160949)	0.793	11
UniProt:Q80U70 Suz12	3	Suz12 [nucleoplasm] (R-MMU-4615932) Suz12 [nucleoplasm] (R-MMU-5617919) Suz12 [nucleoplasm] (R-MMU-212217)	0.723	5
UniProt:Q61188-1 EZH2			0.71	5
UniProt:Q9Z248	1	Aebp2 [nucleoplasm] (R-MMU-5082342)	0.527	2
UniProt:Q02395	1	Mtf2 [nucleoplasm] (R-MMU-5084119)	0.499	3
UniProt:Q7TNS8 EPOP			0.499	2

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