Reactome | DNMT3A [nucleoplasm]

DNMT3A [nucleoplasm]

Stable Identifier

R-HSA-212287

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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External Reference Information

External Reference

UniProt:Q9Y6K1 DNMT3A

Gene Names

DNMT3A

Chain

chain:1-912

Reference Genes

BioGPS Gene:1788 DNMT3A

COSMIC (genes):DNMT3A DNMT3A

CTD Gene:1788 DNMT3A

dbSNP Gene:1788 DNMT3A

ENSEMBL:ENSG00000119772 DNMT3A

ENSEMBL_homo_sapiens_GENE:ENSG00000119772.19 DNMT3A

HGNC:2978 DNMT3A

KEGG Gene (Homo sapiens):1788 DNMT3A

Monarch:1788 DNMT3A

NCBI Gene:1788 DNMT3A

OMIM:602769 DNMT3A

UCSC:Q9Y6K1 DNMT3A

Reference Transcript

Other Identifiers

11718562_a_at

11732775_a_at

11732776_a_at

11740747_a_at

16895344

1788

218457_PM_s_at

218457_s_at

222640_PM_at

222640_at

244428_PM_at

244428_at

2544661

2544663

2544664

2544665

2544666

2544667

2544668

2544669

2544670

2544671

2544672

2544673

2544674

2544676

2544677

2544679

2544681

2544683

2544686

2544690

2544691

2544692

2544693

2544694

2544695

2544696

2544697

2544699

2544700

2544702

2544704

2544705

2544712

2544714

2544715

2544716

2544717

2544718

2544719

2544730

2544733

2544734

2544744

2544745

2557313

43065_at

43066_g_at

60361_at

61520_at

61618_i_at

66989_at

8050813

87064_at

88936_at

90614_at

A_23_P154500

A_23_P420373

A_33_P3272330

GE522551

GE62200

GE668249

GO:0000122

GO:0000775

GO:0000791

GO:0000792

GO:0000978

GO:0001741

GO:0003677

GO:0003682

GO:0003714

GO:0003824

GO:0003886

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006306

GO:0006325

GO:0006346

GO:0006351

GO:0006355

GO:0007283

GO:0008168

GO:0009410

GO:0009636

GO:0010212

GO:0010288

GO:0010468

GO:0012501

GO:0016363

GO:0016740

GO:0022414

GO:0030154

GO:0030182

GO:0031667

GO:0032259

GO:0032355

GO:0032776

GO:0033189

GO:0042220

GO:0042802

GO:0043045

GO:0043226

GO:0044027

GO:0045322

GO:0045471

GO:0045892

GO:0046872

GO:0048856

GO:0061629

GO:0071230

GO:0071361

GO:0071456

GO:0071514

GO:0090116

GO:0097284

GO:0106363

GO:0140096

GO:0140097

GO:0140110

GO:0141068

GO:1900039

GO:1902494

GO:1903926

HMNXSV003000617

HMNXSV003007406

HMNXSV003056285

Hs.188070.0.A1_3p_at

Hs.241565.0.S2_3p_at

ILMN_1654945

ILMN_1676128

ILMN_1698137

PH_hs_0012957

PH_hs_0032270

TC02001658.hg

TC02004120.hg

g12751472_3p_a_at

Participates

as an input of

as a component of

as a member of

DNMT1,3A,3B [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K-DNMT3A [nucleoplasm]

Inferred To

Dnmt3a [nucleoplasm] (Gallus gallus)

dnmt3a [nucleoplasm] (Xenopus tropicalis)

DNMT3A [nucleoplasm] (Bos taurus)

DNMT3A [nucleoplasm] (Canis familiaris)

DNMT3A [nucleoplasm] (Mus musculus)

DNMT3A [nucleoplasm] (Rattus norvegicus)

DNMT3A [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_016859015.1, NP_783328.1, XP_005264232.1, NP_001307821.1, NP_783329.1, NP_072046.2, NP_001307822.1, NP_715640.2, XP_011530969.1, XP_016859016.1, XP_005264234.1

Guide to Pharmacology - Targets

2750

OpenTargets

ENSG00000119772

ZINC - Substances

DNM3A_HUMAN

ZINC target

Q9Y6K1

PRO

Q9Y6K1

PDB

3SVM, 4U7P, 8TE3, 6W8D, 3A1B, 6F57, 4QBR, 3LLR, 6W8B, 5YX2, 8BA5, 6PA7, 6W89, 6W8J, 4U7T, 8TE1, 8TDR, 3A1A, 4QBS, 6BRR, 2QRV, 8TE4, 4QBQ

IntEnz

2.1.1.37

GeneCards

Q9Y6K1

HPA

ENSG00000119772-DNMT3A

Ensembl

ENSP00000370122, ENST00000264709, ENST00000380746, ENST00000321117, ENSG00000119772, ENSP00000324375, ENSP00000264709, ENST00000406659, ENSP00000384852

Pharos - Targets

Q9Y6K1

Orphanet

22958

ZINC - Predictions - Purchasable

DNM3A_HUMAN

HMDB Protein

HMDBP00416

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56279 TCL1A			0.831	13
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.677	6
IntAct:EBI-15583943 H3(112)			0.655	5
UniProt:Q9UJW3-1 DNMT3L			0.652	5
UniProt:Q9UBC3 DNMT3B	2	SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334) DNMT3B [nucleoplasm] (R-HSA-212316)	0.635	4
UniProt:P84243 H3-3A	18	MeK-H3F3A [nucleoplasm] (R-HSA-427369) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) H3R17me2a [nucleoplasm] (R-HSA-9822613) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) H3F3A [extracellular region] (R-HSA-977567) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.618	7
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.61	7
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.602	4
UniProt:Q6FHY5 Q6FHY5			0.601	4
UniProt:Q96T88 UHRF1	2	UHRF1 [cytosol] (R-HSA-9818452) UHRF1 [nucleoplasm] (R-HSA-212103)	0.591	7
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P32242 OTX1			0.556	3
UniProt:Q8N8E2 ZN513			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.556	3
UniProt:Q9Y6K1 DNMT3A	2	monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415) DNMT3A [nucleoplasm] (R-HSA-212287)	0.544	4
IntAct:EBI-15759758 H4R3			0.544	3
UniProt:Q9QR71 LANA1			0.544	3
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.499	2
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.462	3

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