Formation of PRC2-EZH2 complex

Stable Identifier
R-HSA-3240957
Type
Reaction [binding]
Species
Homo sapiens
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The Polycomb repressor complex 2, PRC2-EZH2, consists of 5 proteins: EZH2, EED, RBBP4 (RBAP48), RBBP7 (RBAP46) and SUZ12, and is evolutionarily conserved. While RBBP4 and RBBP7 are proteins involved in various chromatin remodeling complexes, EZH2, EED and SUZ12 belong to the Polycomb group. EZH2 is also a member of the SET family of histone methyltransferases, and PRC2 trimethylates lysine residues K10 and K28 of HIST1H3A (histone H3), with K28 being the preferred site (Kuzmichev et al. 2002).

Literature References
PubMed ID Title Journal Year
12435631 Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Kuzmichev, A, Nishioka, K, Erdjument-Bromage, H, Tempst, P, Reinberg, D

Genes Dev 2002
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