E2F1/2/3 stimulates EED transcription

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R-HSA-3240782
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Reaction [omitted]
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Homo sapiens
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In growing cells, the transcription of EED gene, which codes for a subunit of the Polycomb repressor complex 2 (PRC2), is stimulated by E2F1, E2F2 and E2F3 that bind E2F sites in the EED promoter. Direct binding to EED promoter was directly experimentally examined and confirmed only for E2F3, while it was also demonstrated that E2F1-mediated stimulation of EED gene transcription depends on the intact DNA-binding domain of E2F1. E2F4 also binds EED promoter directly, with the strongest enrichment in G0 (Bracken et al. 2003).

Literature References
PubMed ID Title Journal Year
14532106 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

Bracken, AP, Pasini, D, Capra, M, Prosperini, E, Colli, E, Helin, K

EMBO J. 2003
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