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ARAP1 [cytosol]
Stable Identifier
R-HSA-3211582
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, ARAP1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Homo sapiens)
PTK6 binds ARAP1 (Homo sapiens)
ARAP1 [cytosol] (Homo sapiens)
p-Y342-PTK6:ARAP1 [cytosol] (Homo sapiens)
ARAP1 [cytosol] (Homo sapiens)
PTK6 phosphorylates ARAP1 (Homo sapiens)
p-Y342-PTK6:ARAP1 [cytosol] (Homo sapiens)
ARAP1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
ARAP1 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
ARAP1 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
RHOA GAPs [cytosol] (Homo sapiens)
ARAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96P48 ARAP1
Gene Names
ARAP1, CENTD2, KIAA0782
Chain
chain:1-1450
Reference Genes
BioGPS Gene:116985 ARAP1
COSMIC (genes):ARAP1 ARAP1
CTD Gene:116985 ARAP1
dbSNP Gene:116985 ARAP1
ENSEMBL:ENSG00000186635 ARAP1
HGNC:16925 ARAP1
KEGG:hsa:116985 ARAP1
Monarch:116985 ARAP1
NCBI Gene:116985 ARAP1
OMIM:606646 ARAP1
UCSC:Q96P48 ARAP1
Reference Transcript
RefSeq:NM_001040118.2 ARAP1
RefSeq:NM_015242.4 ARAP1
RefSeq:NM_001135190.1 ARAP1
Other Identifiers
116985
11719038_a_at
11740162_a_at
11758732_at
16741779
212516_3p_at
212516_PM_at
212516_at
238911_PM_at
238911_at
3381240
3381242
3381243
3381244
3381245
3381246
3381247
3381248
3381249
3381250
3381251
3381252
3381253
3381254
3381255
3381256
3381259
3381260
3381261
3381262
3381263
3381264
3381265
3381266
3381267
3381268
3381269
3381270
3381271
3381272
3381273
3381274
3381275
3381276
3381277
3381278
3381279
3381280
3381281
3381284
3381285
3381286
3381288
3381290
3381291
3381292
3381293
3381294
3381295
3381296
3381297
3381298
3381299
3381300
3381301
3381302
3381303
3381304
3381306
3381308
3381309
3381310
3381314
3381361
3381362
3381363
3381364
34206_PM_at
34206_at
7950197
85926_at
92043_at
A_23_P105184
A_24_P398432
A_33_P3416583
GE53485
GO:0001921
GO:0005096
GO:0005515
GO:0005547
GO:0005654
GO:0005737
GO:0005794
GO:0005802
GO:0005829
GO:0005886
GO:0007015
GO:0007165
GO:0008289
GO:0008360
GO:0031702
GO:0032580
GO:0043226
GO:0043231
GO:0043547
GO:0046872
GO:0051056
GO:0051491
GO:0051497
GO:0098772
HMNXSV003030070
Hs.132760.0.S1_3p_at
Hs.21264.0.S1_3p_at
Hs.21264.0.S1_3p_s_at
ILMN_1772233
ILMN_1786357
PH_hs_0022925
TC11003491.hg
Participates
as a candidate of
RHOA GAPs [cytosol] (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
as a member of
CDC42 GAPs [cytosol] (Homo sapiens)
as a component of
p-Y342-PTK6:ARAP1 [cytosol] (Homo sapiens)
as an input of
PTK6 binds ARAP1 (Homo sapiens)
Other forms of this molecule
p-Y231-ARAP1 [cytosol]
Inferred To
Arap1 [cytosol]
(Mus musculus)
Arap1 [cytosol]
(Rattus norvegicus)
ARAP1 [cytosol]
(Bos taurus)
ARAP1 [cytosol]
(Caenorhabditis elegans)
ARAP1 [cytosol]
(Canis familiaris)
ARAP1 [cytosol]
(Sus scrofa)
RhoGAP15B [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_056057.2
,
NP_001128662.1
,
NP_001035207.1
OpenTargets
ENSG00000186635
ENSEMBL
ENST00000429686
,
ENST00000393605
,
ENSP00000352332
,
ENST00000359373
,
ENST00000393609
,
ENSP00000377233
,
ENST00000334211
,
ENSP00000403127
,
ENSP00000335506
,
ENSP00000377230
HPA
ENSG00000186635-ARAP1
PRO
Q96P48
Pharos - Targets
Q96P48
GlyGen
Q96P48
PDB
4X1V
HMDB Protein
HMDBP14131
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.725
5
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.643
5
UniProt:O00220 TNFRSF10A
1
TNFRSF10A [plasma membrane]
(R-HSA-5633393)
0.543
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.527
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
3
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.527
3
UniProt:P47755 CAPZA2
2
CAPZA2(265-276) [extracellular region]
(R-HSA-879417)
CAPZA2 [cytosol]
(R-HSA-879448)
0.527
2
UniProt:P25090 FPR2
4
FPR2 [plasma membrane]
(R-HSA-416408)
FPR2 [ficolin-1-rich granule membrane]
(R-HSA-6803335)
FPR2 [specific granule membrane]
(R-HSA-6803319)
FPR2 [tertiary granule membrane]
(R-HSA-6803296)
0.527
3
UniProt:P12956 XRCC6
5
XRCC6 [nucleoplasm]
(R-HSA-58272)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
0.508
2
UniProt:P27958-PRO_0000037576
0.508
3
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