Reactome | SUMO2,3-K1840-MDC1 [nucleoplasm]

SUMO2,3-K1840-MDC1 [nucleoplasm]

Stable Identifier

R-HSA-4570473

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of DNA damage checkpoint protein 1, MDC1_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
24782567	Proteome-wide identification of SUMO2 modification sites Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT	Sci Signal	2014
22635276	Sumoylation of MDC1 is important for proper DNA damage response Luo, K, Zhang, H, Wang, L, Yuan, J, Lou, Z	EMBO J.	2012

External Reference Information

External Reference

UniProt:Q14676 MDC1

Gene Names

MDC1, KIAA0170, NFBD1

Chain

chain:1-2089

Reference Genes

BioGPS Gene:9656 MDC1

COSMIC (genes):MDC1 MDC1

CTD Gene:9656 MDC1

dbSNP Gene:9656 MDC1

ENSEMBL:ENSG00000137337 MDC1

ENSEMBL:ENSG00000206481 MDC1

ENSEMBL:ENSG00000224587 MDC1

ENSEMBL:ENSG00000225589 MDC1

ENSEMBL:ENSG00000228575 MDC1

ENSEMBL:ENSG00000231135 MDC1

ENSEMBL:ENSG00000234012 MDC1

ENSEMBL:ENSG00000237095 MDC1

HGNC:21163 MDC1

KEGG Gene (Homo sapiens):9656 MDC1

Monarch:9656 MDC1

NCBI Gene:9656 MDC1

OMIM:607593 MDC1

UCSC:Q14676 MDC1

Reference Transcript

Other Identifiers

0006200402

11748150_a_at

11748405_a_at

11751800_a_at

11758138_s_at

17016966

17026706

17028857

17031635

17034090

17036357

17039133

17041700

203061_s_at

203062_s_at

2948565

2948566

2948567

2948568

2948569

2948570

2948571

2948572

2948574

2948575

2948577

2948578

2948579

2948580

2948581

2948582

2948583

2948584

2948586

32661_s_at

32662_at

8124813

8178404

9656

A_23_P19455

D79992_at

GE87930

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005925

GO:0006259

GO:0006281

GO:0006303

GO:0006950

GO:0006974

GO:0007049

GO:0008022

GO:0008150

GO:0016604

GO:0031573

GO:0034641

GO:0042802

GO:0043226

GO:0070975

Hs.277585.0.A1_3p_a_at

ILMN_1814122

PH_hs_0020142

TC06001507.hg

TC6_apd_hap1000077.hg

TC6_cox_hap2000141.hg

TC6_dbb_hap3000130.hg

TC6_mann_hap4000119.hg

TC6_mcf_hap5000120.hg

TC6_qbl_hap6000131.hg

TC6_ssto_hap7000121.hg

g7661965_3p_a_at

Participant Of

output

SUMOylation of MDC1 with SUMO2,3

Other forms of this molecule

SUMO1-K1840-MDC1 [nucleoplasm]

K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]

SUMO2-K1840,p-5T-MDC1 [nucleoplasm]

MDC1 [nucleoplasm]

p-5T-MDC1 [nucleoplasm]

Inferred To

Mdc1 [nucleoplasm] (Mus musculus)

Mdc1 [nucleoplasm] (Rattus norvegicus)

Ptip [nucleoplasm] (Drosophila melanogaster)

MDC1 [nucleoplasm] (Bos taurus)

MDC1 [nucleoplasm] (Canis familiaris)

mdc1 [nucleoplasm] (Danio rerio)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 1840

Coordinate

1840

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_055456.2, XP_011513303.1, XP_011513305.1, XP_005249551.1, XP_016867008.1

OpenTargets

ENSG00000137337

HPA

ENSG00000137337-MDC1

GeneCards

Q14676

Ensembl

ENSG00000231135, ENSP00000415212, ENST00000376406, ENST00000420320, ENSP00000416511, ENST00000435664, ENSG00000228575, ENSP00000409167, ENSG00000234012, ENST00000449153, ENST00000420019, ENSP00000365588, ENSP00000404318, ENSG00000225589, ENSG00000224587, ENST00000383566, ENST00000440369, ENSG00000206481, ENST00000427406, ENSP00000373060, ENSG00000137337, ENSG00000237095, ENSP00000396484, ENSP00000387429

PRO

Q14676

PDB

2AZM, 2ADO, 3UN0, 3UOT, 2ETX, 3UEO, 3UNN, 3K05, 3UMZ, 3UNM

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60934 NBN	3	NBN [nucleoplasm] (R-HSA-75163) NBN [cytosol] (R-HSA-5684005) p-S343-NBN [nucleoplasm] (R-HSA-75237)	0.968	33
UniProt:P16104 H2AX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151)	0.965	21
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.725	11
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.69	9
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.69	9
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.648	4
UniProt:Q13315 ATM	5	Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) ATM [nucleoplasm] (R-HSA-69484) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [peroxisomal matrix] (R-HSA-9665169) ATM [cytosol] (R-HSA-9665171)	0.623	3
UniProt:O96028-1 NSD2			0.602	3
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.591	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.577	4
UniProt:Q14676 MDC1	6	SUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) SUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236)	0.564	2
UniProt:Q9BXW9 FANCD2	3	p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318)	0.527	2
UniProt:O76064-1 RNF8			0.524	2
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.524	3

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