SUMO2,3-K1840-MDC1 [nucleoplasm]

Stable Identifier
R-HSA-4570473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mediator of DNA damage checkpoint protein 1, MDC1_HUMAN
Icon
SUMO2,3-K1840-MDC1 [nucleoplasm] icon
SUMO2,3-K1840-MDC1 [nucleoplasm] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
22635276 Sumoylation of MDC1 is important for proper DNA damage response

Luo, K, Zhang, H, Wang, L, Yuan, J, Lou, Z

EMBO J. 2012
External Reference Information
External Reference
UniProt:Q14676 MDC1
Gene Names
MDC1, KIAA0170, NFBD1
Chain
chain:1-2089
Reference Genes
BioGPS Gene:9656 MDC1
COSMIC (genes):MDC1 MDC1
CTD Gene:9656 MDC1
dbSNP Gene:9656 MDC1
ENSEMBL:ENSG00000137337 MDC1
ENSEMBL:ENSG00000206481 MDC1
ENSEMBL:ENSG00000224587 MDC1
ENSEMBL:ENSG00000225589 MDC1
ENSEMBL:ENSG00000228575 MDC1
ENSEMBL:ENSG00000231135 MDC1
ENSEMBL:ENSG00000234012 MDC1
ENSEMBL:ENSG00000237095 MDC1
HGNC:21163 MDC1
KEGG Gene (Homo sapiens):9656 MDC1
Monarch:9656 MDC1
NCBI Gene:9656 MDC1
OMIM:607593 MDC1
UCSC:Q14676 MDC1
Reference Transcript
Other Identifiers
0006200402
11748150_a_at
11748405_a_at
11751800_a_at
11758138_s_at
17016966
17026706
17028857
17031635
17034090
17036357
17039133
17041700
203061_s_at
203062_s_at
2948565
2948566
2948567
2948568
2948569
2948570
2948571
2948572
2948574
2948575
2948577
2948578
2948579
2948580
2948581
2948582
2948583
2948584
2948586
2ADO
2AZM
2ETX
32661_s_at
32662_at
3K05
3UEO
3UMZ
3UN0
3UNM
3UNN
3UOT
6915
8124813
8178404
9656
A0A087X0R2
A0A1U9XBC1
A0A1U9XBE3
A0A1U9XBF2
A2AB05
A2AB06
A2AB07
A_23_P19455
AAI10646
AAI52557
AB088099
AB103605
AB202097
AL662797
AL662848
AL845353
AQY78598
AQY78600
AQY78604
AQY78607
AQY78609
BA000025
BAA11487
BAB63322
BAC54931
BAE78617
BAF31266
BC110645
BC152556
BX248307
BX927283
CAH18685
CCDS34384
CH471081
CR749828
CR759873
CR788240
CR936878
D79992
D79992_at
EAX03321
ENSG00000137337
ENSG00000206481
ENSG00000224587
ENSG00000225589
ENSG00000228575
ENSG00000231135
ENSG00000234012
ENSG00000237095
ENSP00000365588
ENSP00000373060
ENSP00000387429
ENSP00000396484
ENSP00000404318
ENSP00000409167
ENSP00000415212
ENSP00000416511
ENST00000376406
ENST00000376406.7
ENST00000383566
ENST00000420019
ENST00000420320
ENST00000427406
ENST00000435664
ENST00000440369
ENST00000449153
EntrezGene:9656
EntrezGene:MDC1
g7661965_3p_a_at
GE87930
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005925
GO:0006259
GO:0006281
GO:0006303
GO:0006950
GO:0006974
GO:0007049
GO:0008022
GO:0008150
GO:0016604
GO:0031573
GO:0034641
GO:0042802
GO:0043226
GO:0070975
HGNC:21163
HPA006915
Hs.277585.0.A1_3p_a_at
ILMN_1814122
IPR000253
IPR001357
IPR008984
IPR036420
KY500445
KY500447
KY500451
KY500454
KY500456
MDC1
MDC1-201
MDC1-210
MDC1-219
MDC1-228
MDC1-240
MDC1-248
MDC1-255
MDC1-266
MIM:607593
NM_014641
NP_055456
PF00498
PF16770
PH_hs_0020142
SM00240
TC06001507.hg
TC6_apd_hap1000077.hg
TC6_cox_hap2000141.hg
TC6_dbb_hap3000130.hg
TC6_mann_hap4000119.hg
TC6_mcf_hap5000120.hg
TC6_qbl_hap6000131.hg
TC6_ssto_hap7000121.hg
UPI00001AF453
UPI00004A3B34
UPI0000EE070F
XM_005249492
XM_005249493
XM_005249494
XM_005249497
XM_005249498
XM_011515001
XM_011515003
XM_011515004
XM_017011519
XM_017011520
XM_017011521
XM_017011522
XP_005249549
XP_005249550
XP_005249551
XP_005249554
XP_005249555
XP_011513303
XP_011513305
XP_011513306
XP_016867008
XP_016867009
XP_016867010
XP_016867011
Participant Of
output
Other forms of this molecule
SUMO1-K1840-MDC1 [nucleoplasm]
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
MDC1 [nucleoplasm]
p-5T-MDC1 [nucleoplasm]
Inferred To
Homologues of SUMO2,3-K1840-MDC1 [nucleoplasm] (Drosophila melanogaster)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Bos taurus)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Canis familiaris)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Danio rerio)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Dictyostelium discoideum)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Drosophila melanogaster)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Gallus gallus)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Mus musculus)
SUMO2,3-K1840-MDC1 [nucleoplasm] (Rattus norvegicus)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 1840
Coordinate
1840
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
OpenTargets
GeneCards
PRO
PDB
Interactors (14)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O60934 NBN  3 0.968 33
 UniProt:P16104 H2AFX  7 0.965 21
 UniProt:O76064 RNF8  1 0.725 11
 UniProt:Q92878 RAD50  1 0.69 9
 UniProt:P49959 MRE11  2 0.69 9
 UniProt:P38398 BRCA1  5 0.648 4
 UniProt:Q13315 ATM  3 0.623 3
 UniProt:O96028-1 NSD2      0.602 3
 UniProt:O96028 NSD2  2 0.591 3
 UniProt:Q12888 TP53BP1  3 0.577 4
 UniProt:Q14676 MDC1  6 0.564 2
 UniProt:Q9BXW9 FANCD2  3 0.527 2
 UniProt:O76064-1 RNF8      0.524 2
 UniProt:Q06609 RAD51  2 0.524 3