Reactome | CD2AP [cytosol]

CD2AP [cytosol]

Stable Identifier

R-HSA-373620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CD2-associated protein, CD2AP_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y5K6 CD2AP

Gene Names

CD2AP

Chain

chain:1-639

Reference Genes

BioGPS Gene:23607 CD2AP

COSMIC (genes):CD2AP CD2AP

CTD Gene:23607 CD2AP

dbSNP Gene:23607 CD2AP

ENSEMBL:ENSG00000198087 CD2AP

HGNC:14258 CD2AP

KEGG Gene (Homo sapiens):23607 CD2AP

Monarch:23607 CD2AP

NCBI Gene:23607 CD2AP

OMIM:604241 CD2AP

UCSC:Q9Y5K6 CD2AP

Reference Transcript

RefSeq:NM_012120.2 CD2AP

Other Identifiers

0000050138

11724033_s_at

11724034_at

11724035_at

17009399

203593_at

23607

236257_at

2909403

2909405

2909406

2909407

2909408

2909409

2909415

2909423

2909427

2909432

2909441

2909443

2909444

2909447

2909449

2909450

2909454

2909457

2909465

2909467

2909468

2909469

2909471

2909474

2909475

2909476

2909477

2909478

34699_at

8120102

83120_i_at

83122_r_at

A_14_P132797

A_24_P329152

A_32_P155811

GE79577

GO:0001650

GO:0001726

GO:0003674

GO:0005172

GO:0005198

GO:0005200

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0006810

GO:0006930

GO:0007010

GO:0007015

GO:0007049

GO:0007155

GO:0007165

GO:0008013

GO:0008022

GO:0008150

GO:0009056

GO:0015031

GO:0015629

GO:0016050

GO:0016192

GO:0016477

GO:0017124

GO:0022607

GO:0030054

GO:0030139

GO:0031252

GO:0031410

GO:0031941

GO:0032911

GO:0032991

GO:0040011

GO:0042802

GO:0042995

GO:0043161

GO:0043226

GO:0044877

GO:0045296

GO:0048259

GO:0048471

GO:0048870

GO:0050714

GO:0051058

GO:0051301

GO:0065003

GO:0070062

GO:0098609

GO:1900182

GO:2000249

Hs.149111.0.A1_3p_at

ILMN_1730433

PH_hs_0018127

TC06000633.hg

g11321633_3p_at

Participant Of

input

Nephrin binds CD2AP

hasComponent

CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane]

Cross References

RefSeq

NP_036252.1

OpenTargets

ENSG00000198087

GeneCards

Q9Y5K6

HPA

ENSG00000198087-CD2AP

Ensembl

ENSG00000198087, ENST00000359314, ENSP00000352264

PRO

Q9Y5K6

Orphanet

19254

PDB

2J6K, 4WCI, 2J6F, 2J6O, 3AA6, 3U23, 4X1V, 2J7I, 3LK4, 2FEI

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06729 CD2	1	CD2 [plasma membrane] (R-HSA-197795)	0.802	6
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.796	7
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.747	11
UniProt:P13127 CAPZA1	3	CAPZA1(265-276) [extracellular region] (R-GGA-879421) F-actin-capping protein subunit alpha-1 [cytosol] (R-GGA-994167) CAPZA1 [cytosol] (R-GGA-879363)	0.667	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [cytosol] (R-HSA-182957) SH3KBP1 [plasma membrane] (R-HSA-182955) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.659	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	3
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.573	2
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.573	3
UniProt:P47753	2	Capza1 [cytosol] (R-MMU-879363) Capza1 [extracellular region] (R-MMU-879421)	0.564	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.556	4
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.547	3
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.527	2
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.527	2
UniProt:Q99816 TSG101	1	TSG101 [endosome membrane] (R-HSA-2980549)	0.499	2
UniProt:Q8WV28 BLNK	2	p-5Y-BLNK [plasma membrane] (R-HSA-983579) BLNK [cytosol] (R-HSA-912750)	0.499	2
UniProt:Q68CZ1 RPGRIP1L	1	RPGRIP1L [cytosol] (R-HSA-5610418)	0.462	2
UniProt:Q9Y2H1 ST38L			0.462	4

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