Reactome | CD2AP [cytosol]

CD2AP [cytosol]

Stable Identifier

R-HSA-373620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CD2-associated protein, CD2AP_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y5K6 CD2AP

Gene Names

CD2AP

Chain

chain:1-639

Reference Genes

BioGPS Gene:23607 CD2AP

COSMIC (genes):CD2AP CD2AP

CTD Gene:23607 CD2AP

dbSNP Gene:23607 CD2AP

ENSEMBL:ENSG00000198087 CD2AP

HGNC:14258 CD2AP

KEGG Gene (Homo sapiens):23607 CD2AP

Monarch:23607 CD2AP

NCBI Gene:23607 CD2AP

OMIM:604241 CD2AP

UCSC:Q9Y5K6 CD2AP

Reference Transcript

RefSeq:NM_012120.2 CD2AP

Other Identifiers

0000050138

11724033_s_at

11724034_at

11724035_at

17009399

203593_at

23607

236257_at

2909403

2909405

2909406

2909407

2909408

2909409

2909415

2909423

2909427

2909432

2909441

2909443

2909444

2909447

2909449

2909450

2909454

2909457

2909465

2909467

2909468

2909469

2909471

2909474

2909475

2909476

2909477

2909478

2FEI

2J6F

2J6K

2J6O

2J7I

3267

3326

34699_at

3AA6

3LK4

3U23

4352

4WCI

4X1V

8120102

83120_i_at

83122_r_at

A_14_P132797

A_24_P329152

A_32_P155811

AAD34595

AAF80495

AAH69444

AF146277

AF164377

AL050105

AL355353

AL358178

BC069444

CAB004352

CAB43274

CCDS34472

CD2AP

CD2AP-201

CH471081

EAX04319

ENSG00000198087

ENSP00000352264

ENST00000359314

ENST00000359314.5

EntrezGene:23607

EntrezGene:CD2AP

g11321633_3p_at

GE79577

GO:0001726

GO:0003674

GO:0005172

GO:0005198

GO:0005200

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005856

GO:0005886

GO:0005911

GO:0006810

GO:0006930

GO:0007010

GO:0007015

GO:0007049

GO:0007155

GO:0007165

GO:0008013

GO:0008022

GO:0008150

GO:0009056

GO:0015031

GO:0015629

GO:0016050

GO:0016192

GO:0016477

GO:0017124

GO:0022607

GO:0030054

GO:0030139

GO:0031252

GO:0031410

GO:0031941

GO:0032911

GO:0032991

GO:0040011

GO:0042802

GO:0042995

GO:0043161

GO:0043226

GO:0044877

GO:0045296

GO:0048259

GO:0048471

GO:0048870

GO:0050714

GO:0051058

GO:0051301

GO:0065003

GO:0070062

GO:0098609

GO:1900182

GO:2000249

HGNC:14258

HPA003267

HPA003326

Hs.149111.0.A1_3p_at

ILMN_1730433

IPR001452

IPR028445

IPR035775

IPR035776

IPR035777

IPR036028

MIM:604241

MIM:607832

NM_012120

NP_036252

PF00018

PF14604

PH_hs_0018127

PR00452

SM00326

TC06000633.hg

UPI000006F8C1

XM_005248976

XM_011514449

XM_017010641

XP_005249033

XP_011512751

XP_016866130

Participant Of

input

Nephrin binds CD2AP

hasComponent

CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane]

Cross References

RefSeq

NP_036252.1

OpenTargets

ENSG00000198087

GeneCards

Q9Y5K6

PRO

Q9Y5K6

Orphanet

19254

PDB

2J7I, 2FEI, 2J6F, 3LK4, 2J6K, 4WCI, 3AA6, 2J6O, 3U23, 4X1V

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06729 CD2	1	CD2 [plasma membrane] (R-HSA-197795)	0.802	6
UniProt:P22681 CBL	6	p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940)	0.796	7
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.747	11
UniProt:P13127 CAPZA1	3	CAPZA1(265-276) [extracellular region] (R-GGA-879421) F-actin-capping protein subunit alpha-1 [cytosol] (R-GGA-994167) CAPZA1 [cytosol] (R-GGA-879363)	0.667	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.573	3
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.573	2
UniProt:P47753	2	CAPZA1 [cytosol] (R-MMU-879363) CAPZA1(265-276) [extracellular region] (R-MMU-879421)	0.564	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.556	4
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.547	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [cytosol] (R-HSA-182957) SH3KBP1 [plasma membrane] (R-HSA-182955) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.547	2
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.527	2
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.527	2
UniProt:Q99816 TSG101	1	TSG101 [endosome membrane] (R-HSA-2980549)	0.499	2
UniProt:Q8WV28 BLNK	2	p-5Y-BLNK [plasma membrane] (R-HSA-983579) BLNK [cytosol] (R-HSA-912750)	0.499	2
UniProt:Q68CZ1 RPGRIP1L	1	RPGRIP1L [cytosol] (R-HSA-5610418)	0.462	2
UniProt:Q9Y2H1 ST38L			0.462	4