Reactome | MRPL12 [mitochondrial inner membrane]

MRPL12 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5368256

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

39S ribosomal protein L12, mitochondrial, RM12_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P52815 MRPL12

Gene Names

MRPL12, RPML12, MRPL7

Chain

transit peptide:1-36, chain:37-198, chain:45-198

Reference Genes

BioGPS Gene:6182 MRPL12

COSMIC (genes):MRPL12 MRPL12

CTD Gene:6182 MRPL12

dbSNP Gene:6182 MRPL12

ENSEMBL:ENSG00000262814 MRPL12

HGNC:10378 MRPL12

KEGG:hsa:6182 MRPL12

Monarch:6182 MRPL12

NCBI Gene:6182 MRPL12

OMIM:602375 MRPL12

UCSC:P52815 MRPL12

Reference Transcript

RefSeq:NM_002949.3 MRPL12

Other Identifiers

11744148_at

11763627_a_at

16838879

203931_PM_s_at

203931_s_at

3738207

3738208

3738209

3738210

3738211

3738212

3738213

3738215

3738216

3738217

39812_at

6182

8010664

A_23_P170352

A_33_P3365810

GE60056

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005515

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005762

GO:0005840

GO:0006351

GO:0006355

GO:0006390

GO:0006412

GO:0032543

GO:0043226

GO:0045893

GO:1990904

HMNXSV003018352

ILMN_1699603

PH_hs_0006030

PH_hs_0035524

TC17002410.hg

TC17002882.hg

X79865_at

g4506672_3p_at

Participates

as a component of

39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

MRPL12 [mitochondrial matrix]

Inferred To

mRpL12 [mitochondrial inner membrane] (Drosophila melanogaster)

MRPL12 [mitochondrial inner membrane] (Bos taurus)

MRPL12 [mitochondrial inner membrane] (Canis familiaris)

MRPL12 [mitochondrial inner membrane] (Gallus gallus)

MRPL12 [mitochondrial inner membrane] (Sus scrofa)

mrpl-12 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ghost homologue of MRPL12 [mitochondrial inner membrane] (Danio rerio)

Mrpl12 [mitochondrial inner membrane] (Mus musculus)

Mrpl12 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000262814

ENSEMBL

ENST00000333676, ENSP00000333837, ENSG00000262814

HPA

ENSG00000262814-MRPL12

GeneCards

MRPL12

PRO

P52815

Pharos - Targets

P52815

PDB

6ZSD, 6ZSC, 6ZSG, 7OG4, 7L08, 6ZSE, 8OIR, 7PO2, 8OIT, 6ZSB, 6ZSA, 7O9K, 6ZS9, 6VMI, 6VLZ, 7O9M, 6ZM5, 8ANY, 6ZM6, 7QI5, 7QI4, 7PO4, 7QI6, 7L20

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00411 POLRMT	1	POLRMT [mitochondrial matrix] (R-HSA-163267)	0.748	7
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.615	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.556	3
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:Q9NWR8 MCUB	1	MCUB [mitochondrial inner membrane] (R-HSA-8949153)	0.527	2
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.527	2
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.527	2
UniProt:Q13769 THOC5	3	THOC5 [nucleoplasm] (R-HSA-8849111) THOC5 [cytosol] (R-HSA-9682751) p-Y-THOC5 [cytosol] (R-HSA-9682738)	0.527	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.527	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.527	3
UniProt:P46199 MTIF2	1	MTIF2 [mitochondrial matrix] (R-HSA-5368271)	0.527	3
UniProt:P31146 CORO1A	1	CORO1A [cytosol] (R-HSA-9636432)	0.527	2
UniProt:Q8WVM0 TFB1M	1	TFB1M [mitochondrial matrix] (R-HSA-1592207)	0.527	2
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.527	2
UniProt:P43897 TSFM	1	TSFM [mitochondrial matrix] (R-HSA-5389837)	0.527	2
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.527	2