Reactome | MED8 [nucleoplasm]

MED8 [nucleoplasm]

Stable Identifier

R-HSA-556784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 8, MED8_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED8 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96G25 MED8

Gene Names

MED8

Chain

chain:1-268

Reference Genes

BioGPS Gene:112950 MED8

COSMIC (genes):MED8 MED8

CTD Gene:112950 MED8

dbSNP Gene:112950 MED8

ENSEMBL:ENSG00000159479 MED8

HGNC:19971 MED8

KEGG:hsa:112950 MED8

Monarch:112950 MED8

NCBI Gene:112950 MED8

OMIM:607956 MED8

UCSC:Q96G25 MED8

Reference Transcript

Other Identifiers

112950

11720990_a_at

11742968_a_at

16686140

213126_PM_at

213126_at

213127_PM_s_at

213127_s_at

213696_PM_s_at

213696_s_at

2409343

2409345

2409346

2409347

2409348

2409349

2409350

2409351

2409352

2409353

2409354

2409355

2409356

2409357

2409358

2409359

2409360

2409361

2409362

2409363

2409364

2409366

2409367

33432_at

7915516

A_23_P46170

A_24_P233915

GE83674

GO:0000151

GO:0000978

GO:0003677

GO:0003712

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0016567

GO:0016592

GO:0016740

GO:0032968

GO:0043226

GO:0051123

GO:0060090

GO:0060261

GO:0061630

GO:0065003

GO:0070847

GO:0140096

GO:0140110

HMNXSV003009679

Hs.301756.0.A1_3p_at

Hs.301756.2.S1_3p_a_at

ILMN_1659537

ILMN_1736847

ILMN_2339705

PH_hs_0015562

TC01002584.hg

Participates

as a component of

as an input of

Formation of ARC coactivator complex (Homo sapiens)

Inferred To

MED8 [nucleoplasm] (Sus scrofa)

ELOVL1 [nucleoplasm] (Bos taurus)

Cross References

RefSeq

NP_443109.2, NP_001001653.1, NP_963836.2

OpenTargets

ENSG00000159479

ENSEMBL

ENSP00000290663, ENST00000372455, ENST00000372457, ENSP00000361535, ENSP00000361533, ENST00000290663

HPA

ENSG00000159479-MED8

PRO

Q96G25

Pharos - Targets

Q96G25

GlyGen

Q96G25

PDB

7EMF, 7ENJ, 8GXQ, 8GXS, 7ENC, 7ENA, 7NVR, 7LBM

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.911	13
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.802	9
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.788	7
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.788	8
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.744	6
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.671	6
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.671	6
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.643	4
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.643	4
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.643	6
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.643	5
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.643	5
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.615	3
UniProt:Q9P086 MED11	1	MED11 [nucleoplasm] (R-HSA-556808)	0.564	2
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.548	3
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.548	5
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	3
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.527	3
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.527	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.527	3
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.527	2
UniProt:Q15528 MED22	1	MED22 [nucleoplasm] (R-HSA-556779)	0.527	4
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.527	4
UniProt:P68336 VP16			0.527	2
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	3