SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7

Stable Identifier
R-HSA-9705729
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
ReviewStatus
5/5
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SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
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SOCS1 and SOCS3 recruit Elongin B (ELOB), Elongin C (ELOC), Cullin5 (CUL5), and RNF7 to CSF3R to form a ubiquitin E3 ligase complex (Kamura et al. 2004 and inferred from mouse homologs). SOCS3 has 100-fold higher affinity for CUL5 than SOCS1 has (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
15601820 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kotoshiba, S, Kamura, T, Kohda, D, Maenaka, K, Nakayama, KI, Conaway, JW, Conaway, RC, Matsumoto, M

Genes Dev 2004
Participants
Input
Output
Participates
as an event of
Inferred From
Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7 (Mus musculus)
Authored
May, B  (2020-10-24)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-10-30)
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