SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7

Stable Identifier
R-HSA-9705729
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
ReviewStatus
5/5
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SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
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SOCS1 and SOCS3 recruit Elongin B (ELOB), Elongin C (ELOC), Cullin5 (CUL5), and RNF7 to CSF3R to form a ubiquitin E3 ligase complex (Kamura et al. 2004 and inferred from mouse homologs). SOCS3 has 100-fold higher affinity for CUL5 than SOCS1 has (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
15601820 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T, Maenaka, K, Kotoshiba, S, Matsumoto, M, Kohda, D, Conaway, RC, Conaway, JW, Nakayama, KI

Genes Dev 2004
Participants
Input
Output
Participates
as an event of
Inferred From
Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7 (Mus musculus)
Authored
May, B  (2020-10-24)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-10-30)
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