A ubiquitin E3 ligase complex assembled by SOCS3 or SOCS1 polyubiquitinates a membrane proximal lysine residue of CSF3R (K632 of the mature protein which corresponds to K655 of the preprotein) (Irandoust et al. 2007, Wölfler et al. 2009).
Irandoust, M, Roovers, O, Meenhuis, A, Gits, J, Touw, IP, Wölfler, A
Irandoust, MI, Roovers, O, Aarts, LH, Gits, J, Erkeland, SJ, Touw, IP
ubiquitin protein ligase activity of SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane]
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