SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

Stable Identifier
R-HSA-9705738
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A ubiquitin E3 ligase complex assembled by SOCS3 or SOCS1 polyubiquitinates a membrane proximal lysine residue of CSF3R (K632 of the mature protein which corresponds to K655 of the preprotein) (Irandoust et al. 2007, Wölfler et al. 2009).

Literature References
PubMed ID Title Journal Year
17363902 Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor

Irandoust, MI, Aarts, LH, Roovers, O, Gits, J, Erkeland, SJ, Touw, IP

EMBO J 2007
19453968 Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor

Wölfler, A, Irandoust, M, Meenhuis, A, Gits, J, Roovers, O, Touw, IP

Traffic 2009
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!