Reactome | NEK2 [cytosol]

NEK2 [cytosol]

Stable Identifier

R-HSA-177329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nek2A

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NEK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51955 NEK2

Gene Names

NEK2, NEK2A, NLK1

Chain

chain:1-445

Reference Genes

BioGPS Gene:4751 NEK2

COSMIC (genes):NEK2 NEK2

CTD Gene:4751 NEK2

dbSNP Gene:4751 NEK2

ENSEMBL:ENSG00000117650 NEK2

HGNC:7745 NEK2

KEGG:hsa:4751 NEK2

Monarch:4751 NEK2

NCBI Gene:4751 NEK2

OMIM:604043 NEK2

UCSC:P51955 NEK2

Reference Transcript

Other Identifiers

11722251_a_at

11722252_x_at

11722253_a_at

11749813_a_at

11749814_s_at

11753780_x_at

11761821_at

16698984

204641_PM_at

204641_at

211080_PM_s_at

211080_s_at

2454436

2454437

2454445

2454446

2454449

2454450

2454451

2454452

2454453

2454454

2454455

2454456

2454457

2454458

2454460

2454461

2454462

2454463

2576331

2576335

3527042

3527047

3527051

3527052

366_s_at

3935709

3935713

4751

7924096

A_23_P35219

A_24_P319613

GE62449

GO:0000070

GO:0000228

GO:0000278

GO:0000775

GO:0000776

GO:0000794

GO:0000922

GO:0001824

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0006468

GO:0007010

GO:0007059

GO:0007088

GO:0016740

GO:0019903

GO:0022414

GO:0030496

GO:0032206

GO:0032991

GO:0043226

GO:0046602

GO:0046777

GO:0046872

GO:0048856

GO:0051225

GO:0051299

GO:0051301

GO:0051321

GO:0051988

GO:0090307

GO:0106310

GO:0140096

GO:1903126

HMNXSV003043007

HMNXSV003054140

ILMN_1653822

ILMN_2051373

PH_hs_0031875

TC01003798.hg

TC01006091.hg

Z29066_s_at

g405728_3p_s_at

g4505372_3p_at

Participates

as a component of

as an input of

Association of Nek2A with MCC:APC/C (Homo sapiens)

Inferred To

NEK2 [cytosol] (Bos taurus)

NEK2 [cytosol] (Canis familiaris)

NEK2 [cytosol] (Dictyostelium discoideum)

NEK2 [cytosol] (Gallus gallus)

NEK2 [cytosol] (Mus musculus)

NEK2 [cytosol] (Saccharomyces cerevisiae)

NEK2 [cytosol] (Schizosaccharomyces pombe)

nek2 [cytosol] (Danio rerio)

Ghost homologue of NEK2 [cytosol] (Sus scrofa)

Ghost homologue of NEK2 [cytosol] (Xenopus tropicalis)

Nek2 [cytosol] (Drosophila melanogaster)

Nek2l1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002488.1, XP_005273204.1, NP_001191112.1, NP_001191111.1

ZINC - World Drugs

NEK2_HUMAN

Guide to Pharmacology - Targets

2117

OpenTargets

ENSG00000117650

ENSEMBL

ENST00000366998, ENST00000366999, ENSP00000355966, ENSP00000355965

ZINC - FDA approved

NEK2_HUMAN

ZINC - Substances

NEK2_HUMAN

ZINC - Biogenic

NEK2_HUMAN

ZINC target

P51955

PRO

P51955

PDB

2XK3, 2XK7, 2XNO, 2XK6, 4A4X, 2XKE, 6TM5, 6SGK, 2XK8, 6SGD, 2XK4, 2XNP, 2XNN, 6SK9, 2XNM, 2W5A, 2W5B, 4AFE, 2JAV, 2W5H, 5M51, 5M55, 6SGI, 2XKF, 2XKC, 2WQO, 2XKD, 6SGH, 5M53, 5M57

ZINC - Investigational

NEK2_HUMAN

ZINC - Metabolites

NEK2_HUMAN

HPA

ENSG00000117650-NEK2

Pharos - Targets

P51955

Orphanet

NEK2

ZINC - Predictions - Purchasable

NEK2_HUMAN

HMDB Protein

HMDBP01340

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13042 CDC16	2	CDC16 [cytosol] (R-HSA-174156) CDC16 [nucleoplasm] (R-HSA-174049)	0.643	3
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.623	7
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.623	3
UniProt:Q8NG66 NEK11			0.619	5
UniProt:Q5T7B8 KIF24	1	KIF24 [cytosol] (R-HSA-5626651)	0.619	7
UniProt:P36873-1 PPP1CC			0.592	2
UniProt:Q8R349	2	Cdc16 [nucleoplasm] (R-MMU-174049) Cdc16 [cytosol] (R-MMU-174156)	0.564	3
UniProt:Q99JP4	2	Cdc26 [nucleoplasm] (R-MMU-174216) Cdc26 [cytosol] (R-MMU-174052)	0.564	3
UniProt:Q8BGZ4	2	Cdc23 [nucleoplasm] (R-MMU-174228) Cdc23 [cytosol] (R-MMU-174137)	0.564	4
UniProt:P23508 CRCM			0.547	3
UniProt:Q96PX6 CC85A			0.547	2
UniProt:Q8NHZ8 CDC26	2	CDC26 [cytosol] (R-HSA-174052) CDC26 [nucleoplasm] (R-HSA-174216)	0.527	2
UniProt:P60006 ANAPC15	2	ANAPC15 [cytosol] (R-HSA-6805140) ANAPC15 [nucleoplasm] (R-HSA-6805136)	0.527	2
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.527	2
UniProt:Q6GQ04 Q6GQ04			0.524	2
UniProt:Q83D60 Q83D60			0.488	2

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