Reactome | SMUG1 [nucleoplasm]

SMUG1 [nucleoplasm]

Stable Identifier

R-HSA-110161

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hSMUG1 glycosylase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q53HV7 SMUG1

Gene Names

SMUG1

Chain

chain:1-270

Reference Genes

BioGPS Gene:23583 SMUG1

COSMIC (genes):SMUG1 SMUG1

CTD Gene:23583 SMUG1

dbSNP Gene:23583 SMUG1

ENSEMBL:ENSG00000123415 SMUG1

ENSEMBL:ENSG00000123415.16 SMUG1

HGNC:17148 SMUG1

KEGG Gene (Homo sapiens):23583 SMUG1

Monarch:23583 SMUG1

NCBI Gene:23583 SMUG1

OMIM:607753 SMUG1

UCSC:Q53HV7 SMUG1

Reference Transcript

Other Identifiers

11722278_a_at

11744552_a_at

16765491

218685_PM_s_at

218685_s_at

223684_PM_s_at

223684_s_at

23583

3456598

3456599

3456600

3456601

3456602

3456603

3456604

3456605

3456606

3456609

3456610

3456612

3456615

3456616

53028_at

77762_at

7963741

A_24_P230734

A_24_P75072

A_33_P3292794

GE81909

GO:0000703

GO:0001650

GO:0003677

GO:0003824

GO:0004844

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0006281

GO:0006284

GO:0006974

GO:0016787

GO:0017065

GO:0019104

GO:0042802

GO:0043226

GO:0045008

GO:0055086

GO:0140097

GO:1901135

HMNXSV003049287

ILMN_1804642

PH_hs_0000532

TC12002902.hg

g12653296_3p_a_at

g7657596_3p_a_at

Participates

as an output of

Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)

as a component of

as an input of

SMUG1 glycosylase mediated recognition and binding of uracil in DNA (Homo sapiens)

Inferred To

SMUG1 [nucleoplasm] (Bos taurus)

SMUG1 [nucleoplasm] (Canis familiaris)

SMUG1 [nucleoplasm] (Danio rerio)

SMUG1 [nucleoplasm] (Gallus gallus)

SMUG1 [nucleoplasm] (Mus musculus)

SMUG1 [nucleoplasm] (Rattus norvegicus)

SMUG1 [nucleoplasm] (Sus scrofa)

SMUG1 [nucleoplasm] (Xenopus tropicalis)

Smug [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_011536421.1, XP_006719382.1, NP_055126.1, XP_016874602.1, XP_011536416.1, XP_011536415.1, XP_011536420.1, NP_001230719.1, XP_016874604.1, XP_016874605.1, XP_016874603.1, XP_011536417.1, NP_001230718.1, XP_011536422.1, XP_011536411.1, NP_001230717.1, XP_011536423.1, XP_016874607.1, XP_016874606.1, NP_001230716.1, XP_006719385.1, XP_011536413.1, XP_011536418.1, XP_011536424.1, XP_011536412.1, XP_011536419.1, XP_016874609.1, NP_001230720.1, XP_006719384.1, XP_016874608.1, XP_011536414.1, XP_006719383.1

OpenTargets

ENSG00000123415

GeneCards

Q53HV7

HPA

ENSG00000123415-SMUG1

Ensembl

ENSP00000421139, ENSP00000421206, ENST00000243112, ENST00000401977, ENST00000513838, ENST00000682136, ENST00000337581, ENST00000508394, ENSP00000338606, ENSP00000423629, ENST00000514685, ENST00000506595, ENSP00000243112, ENSG00000123415, ENSP00000424191, ENSP00000507590, ENSP00000384828

PRO

Q53HV7

Pharos - Targets

Q53HV7

HMDB Protein

HMDBP12343

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.666	4
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q93062 RBPMS			0.508	2

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