Reactome | cdc23 [nucleoplasm]

cdc23 [nucleoplasm]

Stable Identifier

R-DRE-174228

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

CDC23, Q7ZVH3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Danio rerio)

- Cell Cycle, Mitotic (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Danio rerio)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Danio rerio)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        Phosphorylation of the APC/C (Danio rerio)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Free APC/C phosphorylated by Plk1 (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Danio rerio)
        
        Degradation of multiubiquitinated Cdh1 (Danio rerio)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Multiubiquitination of APC/C-associated Cdh1 (Danio rerio)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
      - Regulation of APC/C activators between G1/S and early anaphase (Danio rerio)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)

Cellular responses to stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular Senescence (Danio rerio)
    - Senescence-Associated Secretory Phenotype (SASP) (Danio rerio)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Danio rerio)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        cdc23 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7ZVH3

Gene Names

cdc23

Reference Genes

BioGPS Gene:393907 cdc23

ENSEMBL:ENSDARG00000044484

KEGG:dre:393907 cdc23

Monarch:393907 cdc23

NCBI Gene:393907 cdc23

UCSC:Q7ZVH3 cdc23

Reference Transcript

RefSeq:NM_200933.1 cdc23

Other Identifiers

13111443

13278880

393907

A_15_P115577

CJ014215

CUST_6161_PI428451958

DRER09234

DRER39794

Dr.12680.1.S1_at

ENSDART00000065325

ENSDART00000065325_1

ENSDART00000065325_2

GO:0005515

GO:0005680

GT_Spec_NM_200933.1_69541

LOLS06255

MADDr01009114

OTTDART00000026636

XM_697315

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)

Other forms of this molecule

cdc23 [cytosol]

Inferred From

CDC23 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_957227.1

ENSEMBL

ENSDARP00000065324, ENSDART00000065325, ENSDARG00000044484

ZFIN

ZDB-GENE-040426-866

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