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p-FZR1 [nucleoplasm]
Stable Identifier
R-HSA-174257
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phospho-Cdh1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Emi1 with Cdh1 (Homo sapiens)
Cdh1 [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Emi1:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1 [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Phosphorylation of Emi1 (Homo sapiens)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)
Emi1:Cdc20/Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdc20/Cdh1 [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Phospho-Emi1(Ser 182):Cdc20/Cdh1 complexes [nucleoplasm] (Homo sapiens)
Cdc20/Cdh1 [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)
Emi1:Cdc20/Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdc20/Cdh1 [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [nucleoplasm] (Homo sapiens)
Cdc20/Cdh1 [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Homo sapiens)
p-FZR1,p-RB1 [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
p-FZR1 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11598127
Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a
Bembenek, J
,
Yu, H
J Biol Chem
2001
External Reference Information
External Reference
UniProt:Q9UM11 FZR1
Gene Names
FZR1, CDH1, FYR, FZR, KIAA1242
Chain
chain:1-496
Reference Genes
BioGPS Gene:51343 FZR1
COSMIC (genes):FZR1 FZR1
CTD Gene:51343 FZR1
dbSNP Gene:51343 FZR1
ENSEMBL:ENSG00000105325 FZR1
ENSEMBL_homo_sapiens_GENE:ENSG00000105325.15 FZR1
HGNC:24824 FZR1
KEGG Gene (Homo sapiens):51343 FZR1
Monarch:51343 FZR1
NCBI Gene:51343 FZR1
OMIM:603619 FZR1
UCSC:Q9UM11 FZR1
Reference Transcript
RefSeq:NM_001136197.1 FZR1
RefSeq:XM_005259573.4 FZR1
RefSeq:NM_001136198.1 FZR1
RefSeq:NM_016263.3 FZR1
Other Identifiers
11724896_a_at
11724897_a_at
11742066_a_at
16856959
209414_PM_at
209414_at
209415_PM_at
209415_at
209416_3p_s_at
209416_PM_s_at
209416_s_at
211865_PM_s_at
211865_s_at
3816989
3816996
3816997
3816998
3816999
3817000
3817001
3817002
3817005
3817007
3817008
3817009
3817010
3817013
3817015
3817016
3817017
3817018
3817019
3817020
3817021
3817023
3817024
39855_at
41623_s_at
41624_r_at
51343
77105_at
78663_r_at
8024637
A_14_P100190
A_23_P142325
A_23_P142333
A_24_P318836
A_24_P944291
A_33_P3268368
GE62170
GE82097
GO:0000278
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005680
GO:0005737
GO:0005829
GO:0006281
GO:0006974
GO:0007049
GO:0007095
GO:0007346
GO:0008284
GO:0010997
GO:0016567
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0031145
GO:0031965
GO:0036211
GO:0040020
GO:0043226
GO:0048856
GO:0051301
GO:0051445
GO:0051603
GO:0060090
GO:0070306
GO:0070979
GO:0097027
GO:0098772
GO:0140013
GO:1904668
GO:1905786
GO:1990756
GO:1990757
GO:2000773
HMNXSV003003015
HMNXSV003030853
Hs.268384.0.S3_3p_at
Hs.268384.0.S3_3p_x_at
Hs.268384.0.S4_3p_at
ILMN_1753207
PH_hs_0028369
TC19000070.hg
g5813826_3p_a_at
g5813826_3p_x_at
g6463684_3p_a_at
Participates
as an output of
Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)
as a member of
p-FZR1,p-RB1 [nucleoplasm] (Homo sapiens)
Cdh1 [nucleoplasm] (Homo sapiens)
Cdc20/Cdh1 [nucleoplasm] (Homo sapiens)
as a component of
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
FZR1 [cytosol]
FZR1 [nucleoplasm]
p-FZR1 [cytosol]
Inferred To
phospho-fzr1 [nucleoplasm]
(Xenopus tropicalis)
phospho-srw1 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-Fzr1 [nucleoplasm]
(Mus musculus)
phospho-Fzr1 [nucleoplasm]
(Rattus norvegicus)
phospho-cdh1 [nucleoplasm]
(Dictyostelium discoideum)
phospho-CDH1 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-fzr [nucleoplasm]
(Drosophila melanogaster)
phospho-p-FZR1 [nucleoplasm]
(Plasmodium falciparum)
phospho-fzr1a [nucleoplasm]
(Danio rerio)
phospho-FZR1 [nucleoplasm]
(Bos taurus)
phospho-FZR1 [nucleoplasm]
(Canis familiaris)
phospho-FZR1 [nucleoplasm]
(Gallus gallus)
phospho-FZR1 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
XP_005259630.1
,
NP_057347.2
,
NP_001129669.1
,
NP_001129670.1
OpenTargets
ENSG00000105325
HPA
ENSG00000105325-FZR1
GeneCards
Q9UM11
Ensembl
ENST00000313639
,
ENSP00000410369
,
ENST00000652521
,
ENST00000441788
,
ENSP00000378529
,
ENSP00000498659
,
ENST00000395095
,
ENSP00000321800
,
ENSG00000105325
PRO
Q9UM11
Pharos - Targets
Q9UM11
PDB
7QE7
,
5L9U
,
8TAU
,
8TAR
,
5L9T
,
8S4G
,
4UI9
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.879
15
UniProt:Q9UJX6 ANAPC2
2
ANAPC2 [cytosol]
(R-HSA-174229)
ANAPC2 [nucleoplasm]
(R-HSA-174141)
0.802
8
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.643
5
UniProt:Q13042 CDC16
2
CDC16 [nucleoplasm]
(R-HSA-174049)
CDC16 [cytosol]
(R-HSA-174156)
0.643
5
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [nucleoplasm]
(R-HSA-174115)
ANAPC4 [cytosol]
(R-HSA-174168)
0.643
5
UniProt:P31350 RRM2
1
RRM2 [cytosol]
(R-HSA-73639)
0.623
7
UniProt:P20794 MAK
0.602
7
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.564
4
UniProt:P40337-1 VHL
0.544
2
UniProt:Q8IXJ6-2 SIRT2
0.544
2
UniProt:Q96DE5 ANAPC16
2
ANAPC16 [nucleoplasm]
(R-HSA-6805137)
ANAPC16 [cytosol]
(R-HSA-6805138)
0.527
3
UniProt:Q8NHZ8 CDC26
2
CDC26 [nucleoplasm]
(R-HSA-174216)
CDC26 [cytosol]
(R-HSA-174052)
0.527
3
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.524
2
UniProt:Q9HAW4 CLSPN
5
PolyUb-CLSPN [nucleoplasm]
(R-HSA-6783087)
CLSPN(1-1072) [nucleoplasm]
(R-HSA-351929)
CLSPN(1073-1332) [nucleoplasm]
(R-HSA-351935)
CLSPN [nucleoplasm]
(R-HSA-176282)
p-T916,S945-CLSPN [nucleoplasm]
(R-HSA-176296)
0.524
4
UniProt:A2A6Q5
2
Cdc27 [nucleoplasm]
(R-MMU-174175)
Cdc27 [cytosol]
(R-MMU-174073)
0.499
2
UniProt:Q8VDQ8
1
SIRT2 [cytosol]
(R-MMU-2161118)
0.499
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.483
3
UniProt:P0DTD8 NS7B
0.482
2
UniProt:Q8IXJ6 SIRT2
1
SIRT2 [cytosol]
(R-HSA-2161118)
0.462
2
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