2x p-5Y-RET:GDNF:GFRA complexes bind FRS2

Stable Identifier
R-HSA-8855564
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RET can bind FRS2, via phosphotyrosine-1062 (p-Y1062) (Kurokawa et al. 2001, Meillo et al. 2001). FRS2 competes with SHC1 for p-Y1062 binding (Lundgren et al. 2006). RET has been reported to associate with FRS2, instead of SHC1, when associated with lipid rafts (Paratcha et al. 2001).

Literature References
PubMed ID Title Journal Year
11390647 Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

Melillo, RM, Santoro, M, Ong, SH, Billaud, M, Fusco, A, Hadari, YR, Schlessinger, J, Lax, I

Mol. Cell. Biol. 2001
11360177 Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

Kurokawa, K, Iwashita, T, Murakami, H, Hayashi, H, Kawai, K, Takahashi, M

Oncogene 2001
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