Activated FGFR4 binds FRS2

Stable Identifier
R-HSA-5654422
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
Locations in the PathwayBrowser
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Summation

FRS2 (also known as FRS2alpha) is broadly expressed in adult and fetal tissues. Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. The juxtamembrane binding site for FRS2 does not contain tyrosine, so binding may be independent of receptor activation and/or constitutive. Activation of the FGFR receptor is required for FRS2 phosphorylation and subsequent recruitment of downstream effectors.

Literature References
PubMed ID Title Journal Year
18373495 Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Ahmed, Z, Schüller, AC, Suhling, K, Tregidgo, C, Ladbury, JE

Biochem J 2008
9660748 Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

Xu, H, Lee, KW, Goldfarb, M

J Biol Chem 1998
10629055 FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

Ong, SH, Guy, GR, Hadari, YR, Laks, S, Gotoh, N, Schlessinger, J, Lax, I

Mol Cell Biol 2000
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Orthologous Events
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Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)