FRS2 (also known as FRS2alpha) is broadly expressed in adult and fetal tissues. Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. The juxtamembrane binding site for FRS2 does not contain tyrosine, so binding may be independent of receptor activation and/or constitutive. Activation of the FGFR receptor is required for FRS2 phosphorylation and subsequent recruitment of downstream effectors.
Xu, H, Lee, KW, Goldfarb, M
Tregidgo, C, Suhling, K, Ladbury, JE, Ahmed, Z, Schüller, AC
Laks, S, Schlessinger, J, Ong, SH, Lax, I, Gotoh, N, Hadari, YR, Guy, GR
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