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Frs2 [plasma membrane]
Stable Identifier
R-MMU-170963
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
FRS2, Q8C180
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
RET signaling (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
FRS-mediated FGFR1 signaling (Mus musculus)
Activated FGFR1 binds FRS2 (Mus musculus)
Activated FGFR1:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Activated FGFR1 phosphorylates FRS2 (Mus musculus)
Activated FGFR1:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Negative regulation of FGFR1 signaling (Mus musculus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Mus musculus)
Activated FGFR1:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
FRS-mediated FGFR2 signaling (Mus musculus)
Activated FGFR2 binds FRS2 (Mus musculus)
Activated FGFR2:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Activated FGFR2 phosphorylates FRS2 (Mus musculus)
Activated FGFR2:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Negative regulation of FGFR2 signaling (Mus musculus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Mus musculus)
Activated FGFR2:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
FRS-mediated FGFR3 signaling (Mus musculus)
Activated FGFR3 binds FRS2 (Mus musculus)
Activated FGFR3:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Activated FGFR3 phosphorylates FRS2 (Mus musculus)
Activated FGFR3:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Negative regulation of FGFR3 signaling (Mus musculus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Mus musculus)
Activated FGFR3:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
FRS-mediated FGFR4 signaling (Mus musculus)
Activated FGFR4 binds FRS2 (Mus musculus)
Activated FGFR4:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Activated FGFR4 phosphorylates FRS2 (Mus musculus)
Activated FGFR4:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Negative regulation of FGFR4 signaling (Mus musculus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Mus musculus)
Activated FGFR4:FRS2 [plasma membrane] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RND1 GTPase cycle (Mus musculus)
RND1 binds effectors (Mus musculus)
RND1 effectors [cytosol] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
RND1:GTP:RND1 effectors [plasma membrane] (Mus musculus)
RND1 effectors [cytosol] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
RND2 GTPase cycle (Mus musculus)
RND2 binds effectors (Mus musculus)
RND2 effectors [cytosol] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
RND2:GTP:RND2 effectors [plasma membrane] (Mus musculus)
RND2 effectors [cytosol] (Mus musculus)
Frs2 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8C180 Frs2
Gene Names
Frs2, Frs2a
Chain
initiator methionine:1, chain:2-508
Reference Genes
BioGPS Gene:327826 Frs2
KEGG:mmu:327826 Frs2
Monarch:327826 Frs2
NCBI Gene:327826 Frs2
UCSC:Q8C180 Frs2
Reference Transcript
RefSeq:NM_001408284.1 Frs2
RefSeq:NM_001408294.1 Frs2
RefSeq:NM_001408283.1 Frs2
RefSeq:NM_001408285.1 Frs2
RefSeq:NM_001408289.1 Frs2
RefSeq:NM_001408291.1 Frs2
RefSeq:NM_001408286.1 Frs2
RefSeq:NM_001408282.1 Frs2
RefSeq:NM_001408287.1 Frs2
RefSeq:NM_177798.4 Frs2
RefSeq:NM_001408296.1 Frs2
RefSeq:NM_001408297.1 Frs2
RefSeq:NM_001408293.1 Frs2
RefSeq:NM_001408288.1 Frs2
RefSeq:NM_001408292.1 Frs2
RefSeq:NM_001408295.1 Frs2
RefSeq:NM_001408290.1 Frs2
Other Identifiers
10372618
115218_at
1437891_at
1444162_at
17245188
327826
4341790
4348189
4361013
4428139
4477674
4537266
4587272
4628652
4738598
4755262
4766025
4794121
4814497
4878800
4997747
5006977
5007095
5050124
5351947
5363798
5380057
5410462
5410800
5521119
5604305
A_51_P413991
A_52_P105138
A_52_P105147
A_55_P2935763
A_66_P114243
GE1502889
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007405
GO:0008543
GO:0008595
GO:0016020
GO:0030900
GO:0042981
GO:0043410
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:2000726
ILMN_1221488
ILMN_1226775
ILMN_2993711
mMC016758
Participates
as a member of
RND2 effectors [cytosol] (Mus musculus)
RND1 effectors [cytosol] (Mus musculus)
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)
Activated FGFR4 binds FRS2 (Mus musculus)
Activated FGFR1 binds FRS2 (Mus musculus)
Activated FGFR3 binds FRS2 (Mus musculus)
Activated FGFR2 binds FRS2 (Mus musculus)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4:FRS2 [plasma membrane] (Mus musculus)
Activated FGFR1:FRS2 [plasma membrane] (Mus musculus)
Activated FGFR3:FRS2 [plasma membrane] (Mus musculus)
Activated FGFR2:FRS2 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-Frs2 [plasma membrane]
phospho-Frs2 [plasma membrane]
phospho-Frs2 [cytosol]
Frs2 [cytosol]
p-Y-Frs2 [cytosol]
Inferred From
FRS2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001395225.1
,
NP_001395222.1
,
NP_001395223.1
,
NP_001395211.1
,
NP_001395224.1
,
NP_001395212.1
,
NP_001395220.1
,
NP_001395221.1
,
NP_001395226.1
,
NP_001395219.1
,
NP_808466.1
,
NP_001395218.1
,
NP_001395217.1
,
NP_001395215.1
,
NP_001395216.1
,
NP_001395213.1
,
NP_001395214.1
ENSEMBL
ENSMUST00000020381
,
ENSMUSG00000020170
,
ENSMUSP00000020381
PRO
Q8C180
MGI
1100860
GlyGen
Q8C180
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
3
Grb2 [cytosol]
(R-MMU-74686)
Grb2 [plasma membrane]
(R-MMU-202993)
Grb2 [cytosol]
(R-MMU-443287)
0.527
5
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