Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Frs2 [plasma membrane]
Stable Identifier
R-RNO-170963
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
FRS2, D4A244
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
RET signaling (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
FRS-mediated FGFR1 signaling (Rattus norvegicus)
Activated FGFR1 binds FRS2 (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Signaling by FGFR2 (Rattus norvegicus)
Downstream signaling of activated FGFR2 (Rattus norvegicus)
FRS-mediated FGFR2 signaling (Rattus norvegicus)
Activated FGFR2 binds FRS2 (Rattus norvegicus)
Activated FGFR2:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Activated FGFR2 phosphorylates FRS2 (Rattus norvegicus)
Activated FGFR2:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Negative regulation of FGFR2 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Rattus norvegicus)
Activated FGFR2:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Signaling by FGFR3 (Rattus norvegicus)
Downstream signaling of activated FGFR3 (Rattus norvegicus)
FRS-mediated FGFR3 signaling (Rattus norvegicus)
Activated FGFR3 binds FRS2 (Rattus norvegicus)
Activated FGFR3:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Activated FGFR3 phosphorylates FRS2 (Rattus norvegicus)
Activated FGFR3:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Negative regulation of FGFR3 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)
Activated FGFR3:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Signaling by FGFR4 (Rattus norvegicus)
Downstream signaling of activated FGFR4 (Rattus norvegicus)
FRS-mediated FGFR4 signaling (Rattus norvegicus)
Activated FGFR4 binds FRS2 (Rattus norvegicus)
Activated FGFR4:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)
Activated FGFR4:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Negative regulation of FGFR4 signaling (Rattus norvegicus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)
Activated FGFR4:FRS2 [plasma membrane] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RND1 GTPase cycle (Rattus norvegicus)
RND1 binds effectors (Rattus norvegicus)
RND1 effectors [cytosol] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
RND1:GTP:RND1 effectors [plasma membrane] (Rattus norvegicus)
RND1 effectors [cytosol] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
RND2 GTPase cycle (Rattus norvegicus)
RND2 binds effectors (Rattus norvegicus)
RND2 effectors [cytosol] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
RND2:GTP:RND2 effectors [plasma membrane] (Rattus norvegicus)
RND2 effectors [cytosol] (Rattus norvegicus)
Frs2 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D4A244 Frs2
Gene Names
Frs2, Frs2_predicted, rCG_48891
Reference Genes
BioGPS Gene:314850 Frs2
ENSEMBL:ENSRNOG00000005642.7 Frs2
KEGG Gene (Rattus norvegicus):314850 Frs2
Monarch:314850 Frs2
NCBI Gene:314850 Frs2
UCSC:D4A244 Frs2
Reference Transcript
RefSeq:NM_001108097.3 Frs2
RefSeq:XM_006241381.3 Frs2
Other Identifiers
10902524
1377661_at
1397648_at
17835966
314850
5634873
5675836
5712574
5798961
5826181
5881280
5976867
6010249
6309938
6511353
6649050
6744902
A_42_P663544
A_44_P449422
A_44_P548740
GE1101176
GE1154943
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005737
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007405
GO:0008543
GO:0008595
GO:0012501
GO:0022414
GO:0023052
GO:0030154
GO:0030900
GO:0042981
GO:0043410
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:2000726
ILMN_1373764
PH_rn_0013162
rc_AA996518_at
rc_AI233853_at
Participates
as a member of
RND2 effectors [cytosol] (Rattus norvegicus)
RND1 effectors [cytosol] (Rattus norvegicus)
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)
Activated FGFR4 binds FRS2 (Rattus norvegicus)
Activated FGFR1 binds FRS2 (Rattus norvegicus)
Activated FGFR3 binds FRS2 (Rattus norvegicus)
Activated FGFR2 binds FRS2 (Rattus norvegicus)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:FRS2 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
Frs2 [cytosol]
p-Y-Frs2 [cytosol]
phospho-Frs2 [cytosol]
Frs2 [cytosol]
phospho-Frs2 [cytosol]
phospho-Frs2 [plasma membrane]
phospho-Frs2 [plasma membrane]
Inferred From
FRS2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_006241443.1
,
NP_001101567.2
Ensembl
ENSRNOG00000005642
,
ENSRNOP00000007472
,
ENSRNOT00000007472
RGD
1308201
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text