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FRS2 [plasma membrane]
Stable Identifier
R-GGA-170963
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
FRS2, E1C021
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
RET signaling (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
FRS-mediated FGFR1 signaling (Gallus gallus)
Activated FGFR1 binds FRS2 (Gallus gallus)
Activated FGFR1:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 phosphorylates FRS2 (Gallus gallus)
Activated FGFR1:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Negative regulation of FGFR1 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)
Activated FGFR1:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
FRS-mediated FGFR2 signaling (Gallus gallus)
Activated FGFR2 binds FRS2 (Gallus gallus)
Activated FGFR2:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR2 phosphorylates FRS2 (Gallus gallus)
Activated FGFR2:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Negative regulation of FGFR2 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Gallus gallus)
Activated FGFR2:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
FRS-mediated FGFR3 signaling (Gallus gallus)
Activated FGFR3 binds FRS2 (Gallus gallus)
Activated FGFR3:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR3 phosphorylates FRS2 (Gallus gallus)
Activated FGFR3:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Negative regulation of FGFR3 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Gallus gallus)
Activated FGFR3:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
FRS-mediated FGFR4 signaling (Gallus gallus)
Activated FGFR4 binds FRS2 (Gallus gallus)
Activated FGFR4:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR4 phosphorylates FRS2 (Gallus gallus)
Activated FGFR4:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Negative regulation of FGFR4 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)
Activated FGFR4:FRS2 [plasma membrane] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase cycle (Gallus gallus)
RND1 GTPase cycle (Gallus gallus)
RND1 binds effectors (Gallus gallus)
RND1 effectors [cytosol] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
RND1:GTP:RND1 effectors [plasma membrane] (Gallus gallus)
RND1 effectors [cytosol] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
RND2 GTPase cycle (Gallus gallus)
RND2 binds effectors (Gallus gallus)
RND2 effectors [cytosol] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
RND2:GTP:RND2 effectors [plasma membrane] (Gallus gallus)
RND2 effectors [cytosol] (Gallus gallus)
FRS2 [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:E1C021
Gene Names
FRS2
Reference Genes
BioGPS Gene:417845 FRS2
ENSEMBL:ENSGALG00000009966
ENSEMBL:ENSGALG00010013280.1 FRS2
KEGG Gene (Gallus gallus):417845 FRS2
Monarch:417845 FRS2
NCBI Gene:417845 FRS2
Reference Transcript
RefSeq:XM_015281751.1 FRS2
RefSeq:XM_015281754.1 FRS2
RefSeq:NM_001199626.2 FRS2
Other Identifiers
417845
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005737
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007405
GO:0008543
GO:0008595
GO:0012501
GO:0022414
GO:0023052
GO:0030154
GO:0030900
GO:0042981
GO:0043410
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:2000726
GT_A_87_P106493
GgaAffx.6261.1.S1_at
Participates
as a member of
RND2 effectors [cytosol] (Gallus gallus)
RND1 effectors [cytosol] (Gallus gallus)
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)
Activated FGFR4 binds FRS2 (Gallus gallus)
Activated FGFR1 binds FRS2 (Gallus gallus)
Activated FGFR3 binds FRS2 (Gallus gallus)
Activated FGFR2 binds FRS2 (Gallus gallus)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR4:FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1:FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR3:FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR2:FRS2 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-FRS2 [cytosol]
FRS2 [cytosol]
phospho-FRS2 [cytosol]
phospho-FRS2 [plasma membrane]
phospho-FRS2 [plasma membrane]
Inferred From
FRS2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_015137237.1
,
XP_015137240.1
,
NP_001186555.1
OpenTargets
ENSG00000166225
Ensembl
ENSGALT00010031934
,
ENSGALG00010013280
,
ENSGALP00010018730
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