FRS2 (also known as FRS2alpha) is broadly expressed in adult and fetal tissues. Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. The juxtamembrane binding site for FRS2 does not contain tyrosine, so binding may be independent of receptor activation and/or constitutive. Activation of the FGFR receptor is required for FRS2 phosphorylation and subsequent recruitment of downstream effectors.
Ahmed, Z, Schüller, AC, Suhling, K, Tregidgo, C, Ladbury, JE
Xu, H, Lee, KW, Goldfarb, M
Ong, SH, Guy, GR, Hadari, YR, Laks, S, Gotoh, N, Schlessinger, J, Lax, I
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