Reactome | Activated FGFR3 binds FRS2

Activated FGFR3 binds FRS2

Stable Identifier

R-HSA-5654409

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR3 (Homo sapiens)
      - Downstream signaling of activated FGFR3 (Homo sapiens)
        
        FRS-mediated FGFR3 signaling (Homo sapiens)
        
        Activated FGFR3 binds FRS2 (Homo sapiens)

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FRS2 (also known as FRS2alpha) is broadly expressed in adult and fetal tissues. Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. The juxtamembrane binding site for FRS2 does not contain tyrosine, so binding may be independent of receptor activation and/or constitutive. Activation of the FGFR receptor is required for FRS2 phosphorylation and subsequent recruitment of downstream effectors.

Literature References

PubMed ID	Title	Journal	Year
9660748	Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins Xu, H, Lee, KW, Goldfarb, M	J Biol Chem	1998
18373495	Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling Ahmed, Z, Schüller, AC, Suhling, K, Tregidgo, C, Ladbury, JE	Biochem J	2008
10629055	FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors Ong, SH, Guy, GR, Hadari, YR, Laks, S, Gotoh, N, Schlessinger, J, Lax, I	Mol Cell Biol	2000